Results 31 to 40 of about 36,402 (277)

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases

Frontiers in Pharmacology, 2019
Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in ...
Chao Yu, Shougang Zhuang, Shougang Zhuang   +2 more
doaj   +1 more source

Wall Tension and Tubular Resistance in Kidney Cystic Conditions

Biomedicines, 2023
The progressive formation of single or multiple cysts accompanies several renal diseases. Specifically, (i) genetic forms, such as adult dominant polycystic kidney disease (ADPKD), and (ii) acquired cystic kidney disease (ACKD) are probably the most ...
Michele Della Corte, Davide Viggiano
doaj   +1 more source

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases

Metabolites, 2019
Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer ...
Hayley Abbiss, Garth L. Maker, Robert D. Trengove   +2 more
doaj   +1 more source

Localized cystic kidney disease: a case report unveiling clinical and histopathological challenges

Autopsy and Case Reports
Localized cystic kidney disease (LCKD) is a distinct renal disorder characterized by the presence of cysts within specific regions of the kidneys. We present a rare case of a 41-year-old African American man, who presented to our medical center with ...
Teresita Mendez, Hisham F. Bahmad, Francesca Polit, Nicole Carpio, Arman Gill, William F. Burke III, Akshay Bhandari, Robert Poppiti, Yumna Omarzai   +8 more
doaj   +1 more source

Case Report: Autosomal dominant polycystic kidney disease and Wilms’ tumor in infancy and childhood

Frontiers in Pediatrics
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is rare but one of the most common inherited kidney diseases. Normal kidney function is maintained until adulthood in most patients.
Doviltyte Zina, Doviltyte Zina, Kiudeliene Rosita, Kiudeliene Rosita, Zviniene Kristina, Zviniene Kristina, Rutkauskiene Giedre, Rutkauskiene Giedre, Masalskiene Jurate, Masalskiene Jurate   +9 more
doaj   +1 more source

Polycystic Kidney Disease Drug Development: A Conference Report

Kidney Medicine, 2023
Autosomal dominant polycystic kidney disease (ADPKD) is part of a spectrum of inherited diseases that also includes autosomal recessive polycystic kidney disease, autosomal dominant polycystic liver disease, and an expanding group of recessively ...
Max C. Liebau, Djalila Mekahli, Ronald Perrone, Belle Soyfer, Sorin Fedeles   +4 more
doaj  

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

PKD1-associated autosomal dominant polycystic kidney disease with glomerular cysts presenting with nephrotic syndrome caused by focal segmental glomerulosclerosis

BMC Nephrology, 2019
Background Autosomal dominant polycystic kidney disease (ADPKD) may manifest non-nephrotic range proteinuria, but is rarely complicated with nephrotic syndrome.
Yasuhiro Oda, Naoki Sawa, Eiko Hasegawa, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara   +15 more
doaj   +1 more source

Spontaneous Polycystic Kidneys with Chronic Renal Failure in an Aged House Musk Shrew (Suncus murinus)

Veterinary Sciences, 2022
Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts. This disease is a progressive and unfortunately incurable condition.
Tohru Kimura
doaj   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source