Results 111 to 120 of about 31,827 (245)

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu, Hui Wang, Liyuan Chen, Xiaoxia Wu, Zhiyong Xu, Qingfa Huang, Hu Zhang, Xiushu Cao, Xinyuan Liang, Xingjian Zhong, Caiqun Luo   +10 more
wiley   +1 more source

Joint Association of Diet Index for Gut Microbiota and MVPA With Central Obesity: The Mediating Role of Biological Age

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This study found that higher dietary index for gut microbiota (DI‐GM) scores and adequate moderate‐to‐vigorous physical activity (MVPA) were both independently associated with lower central obesity prevalence. Participants with both high DI‐GM (≥ 6) and recommended MVPA showed a 40% reduced risk of central obesity. Biological age partially mediated the
Qi Zhou, Caifa Tang, Xin Pan, Zuyao Lu, Rujun Chen, Xiaohua Gong   +5 more
wiley   +1 more source

Heterozygosity of ALG9 in Association with Autosomal Dominant Polycystic Liver Disease. [PDF]

Genes (Basel), 2023
Boerrigter MM, Duijzer R, Te Morsche RHM, Drenth JPH.   +3 more
europepmc   +1 more source

An Unusual Cause of a High Carbonhydrate Antigen 19–9 Level in an Elderly Individual: Polycystic Liver Disease [PDF]

, 2015
Bülent Yılmaz, Emir Charles Roach, Seyfettin Köklü   +2 more
openalex   +1 more source

Changes in Metabolites and Microbial Communities in Follicular Fluid Associated With Ovarian Function in Patients With Polycystic Ovary Syndrome

MedComm, Volume 7, Issue 2, February 2026.
Based on the integrated analysis of follicular fluid metabolites and microbial communities in patients with PCOS, this study reveals significant dysregulation in the follicular microenvironment. Key metabolites including D‐glucose and 25‐hydroxycholesterol show marked alterations, while microbial communities such as Alicyclobacillus and Terrimonas ...
Manfei Si, Sen Yan, Shu Ding, Rui Liu, Xianglei Xiong, Jie Qiao, Xinyu Qi   +6 more
wiley   +1 more source

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source

Tratamiento quirúrgico de la enfermedad poliquística hepática autosómica dominante, serie de casos

Revista Colombiana de Cirugía
Nowadays liver and biliary tract surgery are the most commonly performed procedures worldwide; refinement in surgical techniques, anesthetic care and liver transplantation have revolutionized the treatment of liver diseases that were previously incurable.
Andrés Ayala, Juan Carlos Aguilar, Fernando Jiménez, Frans Serpa   +3 more
doaj  

Novel α-1,3-Glucosyltransferase Variants and Their Broad Clinical Polycystic Liver Disease Spectrum. [PDF]

Genes (Basel), 2023
Boerrigter MM, Te Morsche RHM, Venselaar H, Pastoors N, Geerts AM, Hoorens A, Drenth JPH.   +6 more
europepmc   +1 more source

Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang, Yu‐Jie Chen, Yu‐Xin Hu, Jia‐Chen Liu, Min Hu   +4 more
wiley   +1 more source

A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease. [PDF]

Sci Transl Med, 2023
Waddell SH, Yao Y, Olaizola P, Walker A, Jarman EJ, Gournopanos K, Gradinaru A, Christodoulou E, Gautier P, Boerrigter MM, Cadamuro M, Fabris L, Drenth JP, Kendall TJ, Banales JM, Khamseh A, Mill P, Boulter L.   +17 more
europepmc   +1 more source