Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology [PDF]
Cholangiocytes are epithelial cells lining the biliary epithelium. Cholangiocytes play several key roles in the modification of ductal bile and are also the target cells in chronic cholestatic liver diseases (i.e., cholangiopathies) such as PSC, PBC ...
Alvaro, Domenico+6 more
core +1 more source
Plain Language Summary of the ACCEPT Guideline for the Management of Recurrent Pregnancy Loss
ABSTRACT Recurrent pregnancy loss (RPL) is when a woman experiences two or more pregnancy losses. Investigating for causes of RPL can provide an explanation and possible treatment options. This is a summary of Parts 1 and 2 of Australasian Recurrent Pregnancy Loss Clinical Management Guidelines in an easy‐to‐read patient friendly format. These original
Adriana Suker+4 more
wiley +1 more source
Obstructive Jaundice Associated with Polcystic Liver Disease [PDF]
A 65 year old patient with polycystic liver disease presented with obstructive jaundice thought to be a cholangiocarcinoma. Subsequent investigations demonstrated a large cyst compressing the confluence of the hepatic ducts. Percutaneous decompression of
Buckels, J. A. C.+2 more
core +3 more sources
A noncoding variant in GANAB explains isolated polycystic liver disease (PCLD) in a large family
Expanded mutation detection and novel gene discovery for isolated polycystic liver disease (PCLD) are necessary as 50% of cases do not have identified mutations in the seven published disease genes.
Whitney Besse+6 more
semanticscholar +1 more source
ACCEPT Group Condensed Position Paper on the Management of Recurrent Pregnancy Loss
ABSTRACT The Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) group recently published an evidence‐based guideline on the investigation and management of recurrent pregnancy loss (RPL).
Adriana Suker+4 more
wiley +1 more source
Polycystic Diseases in Visceral Organs
Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory ...
Shakila Abdul-Majeed, Surya M. Nauli
doaj +1 more source
Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]
Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L.+4 more
core +2 more sources
Polycystic liver disease (PLD) occurs in two genetic disorders, autosomal‐dominant polycystic kidney disease (ADPKD) and autosomal‐dominant polycystic liver disease (ADPLD).
René M M van Aerts+7 more
semanticscholar +1 more source
Postprandial Hyperglycaemia Screening and Pregnancy Outcomes‐Lessons From COVID ‐19
ABSTRACT Background During COVID‐19, the diagnosis and treatment of GDM differed from conventional criteria. In Australia, during the alternative testing period, women with fasting glucose < 4.7 mmol/L were not diagnosed with GDM. Aim To describe the maternal and neonatal outcomes of pregnant women with fasting blood glucose < 4.7 mmol/L for whom the ...
Beenu Bastian+4 more
wiley +1 more source
Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras/Raf dependent signalling pathway [PDF]
Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent cyst formation.
Harris, P.C.+7 more
core +1 more source