Results 61 to 70 of about 149 (135)

Indeed, safety comes first for the use of GLP‐1RAs

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 1000-1001, May 2025.
Amruta D. S. Pathare, Alberto Sola‐Leyva, Apostol Apostolov, Ganesh Acharya, Andres Salumets   +4 more
wiley   +1 more source

The Impact of Metformin on Plasma Prolactin Levels in Antipsychotics‐Treated Men With Hyperprolactinemia and Early‐Onset Androgenic Alopecia

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Metformin decreases elevated levels of pituitary hormones. Little is known about the association between the reproductive axis and hormonal effects of this drug. The purpose of our study was to investigate whether activity of the hypothalamic‐pituitary‐gonadal axis determines metformin action on prolactin levels in men with prolactin
Robert Krysiak, Karolina Kowalcze, Marek Krzystanek, Witold Szkróbka, Bogusław Okopień   +4 more
wiley   +1 more source

Effect of glucagon‐like peptide 1 receptor agonists on systolic blood pressure in patients with obesity, with or without diabetes: A systematic review and network meta‐analysis

Clinical Obesity, EarlyView.
Summary The effect of glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) on systolic blood pressure (SBP) in patients with obesity with or without diabetes remains unclear. The aim was to compare the effect of different drug–dose combinations of GLP‐1RAs on SBP.
Abraish Ali, Asad Ali Siddiqui, Muhammad Shariq Usman, Izza Shahid, Muhammad Shahzeb Khan, Prinka Perswani   +5 more
wiley   +1 more source

Polycystic ovary syndrome: What to say when asked about the chance of pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Laure Morin‐Papunen, Sari Pelkonen, Terhi Piltonen   +2 more
wiley   +1 more source

Ciliary IFT‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

Cell Proliferation, EarlyView.
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang, Jing Zhang, Fei Yan, Yihong Chen, Yang Wu, Jiaxin Luo, Lian Duan, Juan Zou, Juncen Guo, Jiyun Pang, Andras Dinnyes, Jiuzhi Zeng, Weixin Liu, Chi Chiu Wang, Yi Lin, Xue Xiao, Xiaomiao Zhao, Wenming Xu   +17 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Designing a regional clinical service for people with early‐onset type 2 diabetes in England

Diabetic Medicine, Volume 42, Issue 4, April 2025.
Abstract Aims To design a regional clinical service for people with early‐onset type 2 diabetes (EOT2D) in Leicester, Leicestershire and Rutland (England). Methods A literature search was undertaken to identify important considerations. A working group of key stakeholders was formed to design a triage system and service pathway.
Jonathan Goldney, Victoria Alabraba, Priscilla Sarkar, Harriet Morgan, Malak Hamza, Michael Skarlatos, Tommy Slater, Jack A. Sargeant, Rhys O'Callaghan, Michelle Hadjiconstantinou, Julia Burdon, Azhar Farooqi, Samuel Seidu, Claire Meek, Melanie J. Davies   +14 more
wiley   +1 more source

Shortcut to the needle in the haystack? Screening for maturity onset diabetes of the young in a population of women with gestational diabetes

Diabetic Medicine, Volume 42, Issue 5, May 2025.
Abstract Aims Pregnant women are occasionally misdiagnosed with gestational diabetes (GDM) when they may have glucokinase monogenic diabetes (GCK‐MODY). Differentiating between GCK‐MODY and GDM is critical due to the distinct treatment strategies required during and after pregnancy.
Sine Knorr, Laura L. Knudsen, Anne L. Madsen, Lene R. Madsen, Lene Mortensen, Henrik H. Thomsen, Lars Peter Sørensen, Per G. Ovesen, Jens Fuglsang, Ulla Kampmann   +9 more
wiley   +1 more source

Efficacy and safety of once‐weekly semaglutide 2.4 mg for weight management in participants from China: A prespecified analysis of the STEP 7 randomized clinical trial

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2540-2551, May 2025.
Abstract Aim To evaluate the efficacy and safety of semaglutide 2.4 mg versus placebo for weight management in a population of Chinese adults with overweight or obesity. Materials and Methods In STEP 7 (NCT04251156), a double‐blind, phase 3a trial, adults from a predominantly East Asian population with overweight or obesity, with or without type 2 ...
Weijun Gu, Yibing Lu, Xinhua Ye, Guoyue Yuan, Dongmei Liu, Zewei Shen, Ning Zu, Yiming Mu   +7 more
wiley   +1 more source

Real‐world use and effectiveness of tirzepatide among individuals without type 2 diabetes: Results from the Optum Market Clarity database

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2810-2821, May 2025.
Abstract Aims To understand real‐world tirzepatide utilization and effectiveness (change in weight and body mass index [BMI]) among people without type 2 diabetes (T2D) in the United States. Materials and Methods This retrospective, observational study used Optum's de‐identified Market Clarity database (index date: first‐observed tirzepatide claim ...
Emily R. Hankosky, Chanadda Chinthammit, Alexandra Meeks, Ahong Huang, Jennifer M. Ward, Donna Mojdami, Theresa Hunter Gibble   +6 more
wiley   +1 more source