Results 41 to 50 of about 300,077 (226)

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVE: The aim of this study was to detect the following mutations: JAK2 V617F, JAK2 exon
Leonardo Caires dos Santos   +5 more
doaj   +1 more source

Treatment of polycythemia vera [PDF]

open access: yesVnitřní lékařství, 2018
Polycythemia vera is a chronic myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation resulting in erythrocytosis, leukocytosis and thrombocytosis. Survival is reduced compared with general population.
openaire   +2 more sources

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study

open access: yesLeukemia, 2020
Rambaldi, A., Iurlo, A., Vannucchi, A. M., Noble, R., von Bubnoff, N., Guarini, A., Martino, B., Pezzutto, A., Carli, G., De Muro, M., Luciani, S., McMullin, M. F., Cambier, N., Marolleau, J-P., Mesa, R. A., Tibes, R., Pancrazzi, A., Gesullo, F., Bettica,
A. Rambaldi   +20 more
semanticscholar   +1 more source

Polycythemia vera masked due to severe iron deficiency anemia

open access: yesHematology/Oncology and Stem Cell Therapy, 2018
Polycythemia vera is one of the chronic myeloproliferative diseases and very few patients present with its actual clinical manifestations. The most common findings are increased red cell mass and an increased leukocyte count with decreased erythropoietin.
Shweta Kambali, Asma Taj
doaj   +1 more source

Thromboembolic events in polycythemia vera

open access: yesAnnals of Hematology, 2019
Thromboembolic events and cardiovascular disease are the most prevalent complications in patients with polycythemia vera (PV) compared with other myeloproliferative disorders and are the major cause of morbidity and mortality in this population. Moreover,
M. Griesshammer, J. Kiladjian, C. Besses
semanticscholar   +1 more source

The role of a low erythropoietin level for the polycythemia vera diagnosis.

open access: yesBlood Cells, Molecules & Diseases, 2020
A low erythropoietin (EPO) level is a minor diagnostic criterion for polycythemia vera (PV). Controversies exist regarding the diagnostic value of a low EPO level when considering increasing availability of advanced molecular testing.
Oleksandra Lupak   +5 more
semanticscholar   +1 more source

Polycythemia vera as a presentation of renal angiomyolipoma: a case report

open access: yesJournal of Medical Case Reports, 2009
Introduction Angiomyolipoma is a common benign renal tumor composed of thick-walled blood vessels, smooth muscle, and adipose tissue. It may be found incidentally during workup for suspected renal disease.
Lin Ming-Shyan   +7 more
doaj   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet   +11 more
wiley   +1 more source

Parathyroid Adenoma as a Rare Cause of Persistent Hypercalcemia in a Female with Polycythemia Vera

open access: yesCase Reports in Oncology, 2020
Polycythemia vera is one of the myeloproliferative neoplasms that is distinguished by the uncontrolled production of blood cells and an increased red cell mass due to acquired JAK2 mutation.
Ahmed M. Abdalhadi, Mohamed A. Yassin
doaj   +1 more source

The utility of testing erythropoietin level in polycythemia diagnosis

open access: yesHematology, 2023
Objectives: Polycythemia vera (PV) is classically thought to be associated with low erythropoietin (EPO) levels. Here, we present a review of the utility of using EPO levels in diagnosing polycythemia.Methods: We conducted a systematic literature review ...
Abdellatif Ismail   +7 more
doaj   +1 more source

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