Results 1 to 10 of about 577,308 (213)

JAK2-V617F mutation in patients with myeloproliferative neoplasms: Association with FLT3-ITD mutation [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. An acquired somatic mutation V617F in Janus kinase 2 gene (JAK2) is the cause of uncontrolled proliferation in patients with myeloproliferative neoplasms.
Čolović Milica, Kostić Tatjana, Pavlović Sonja, Spasovski Vesna, Tošić Nataša   +4 more
doaj   +2 more sources

Determination of the JAK2 V617F mutation in thrombosis patients

Journal of Associated Medical Sciences, 2023
Background: Janus kinase 2 (JAK2) gene mutation causes uncontrolled myeloproliferation independent of cytokines and abnormal formation of the endogenous erythroid colony.
Sutada Magmuang, Roongrudee Singdong, Takol Chareonsirisuthigul, Budsaba Rerkamnuaychoke, Suchada Sommaluan, Dollawat Sae-chua, Teerapong Siriboonpiputtana, Teeraya Puavilai   +7 more
doaj   +2 more sources

CRISPR/Cas12a-Based Ultrasensitive and Rapid Detection of JAK2 V617F Somatic Mutation in Myeloproliferative Neoplasms

Biosensors, 2021
The JAK2 V617F mutation is a major diagnostic, therapeutic, and monitoring molecular target of Philadelphia-negative myeloproliferative neoplasms (MPNs).
Miaomiao Chen, Chunhua Zhang, Zhiqing Hu, Zhuo Li, Menglin Li, Lingqian Wu, Miaojin Zhou, Desheng Liang   +7 more
doaj   +2 more sources

Clinical characteristics of a patient with de novo acute promyelocytic leukemia with JAK2 v617f mutation

Hematology, 2022
Background: The V617F mutation of Janus-associated kinase 2 (JAK2) is common in myeloproliferative neoplasms (MPN). JAK2 V617F mutation can be detected in patients with de novo acute myeloid leukemia (AML), but de novo acute promyelocytic leukemia (APL ...
Yi-zhi Jiang, Zhong-ling Wei, Na-na Wang, Chen Huang, Jun Huang, Jia-wei Yan, Ran Wang, Zheng-zhi Yu, Dong-ping Huang   +8 more
doaj   +1 more source

Impact of JAK2 V617F mutation on hemogram variation in patients with non-reactive elevated platelet counts. [PDF]

PLoS ONE, 2013
BACKGROUND: Non-reactive platelet counts elevation occurs mainly in myeloproliferative disorders (MPDs), which have been reported to be closely associated with JAK2 V617F mutation.
Juan Zhou, Yuanxin Ye, Shugen Zeng, Yi Zhou, Zhigang Mao, Xingbo Song, Binwu Ying, Xiaojun Lu, Hong Jiang, Lanlan Wang   +9 more
doaj   +1 more source

DIAGNOSTIC VALUE OF JAK2 V617F MUTATIONAL SCREENING IN PATIENTS WITH BUDD-CHIARI SYNDROME [PDF]

Ain Shams Medical Journal, 2019
Background: The diagnosis of underlying myeloproliferative neoplasms (MPNs) is often problematic in patients with Budd Chiari syndrome (BCS). A clonal mutation in JAK2 tyrosine kinase (JAK2V617F) occurs in a high proportion of patients with MPNs and is ...
Esraa A, Noha Mostafa, Mona Elfattah, Iman Omar   +3 more
doaj   +1 more source

Clinical and laboratory relevance of JAK2 V617F and BCR-ABL co-existence in Philadelphia positive CML patients

Pakistan Journal of Pharmaceutical Sciences, 2021
Chronic Myeloid Leukaemia (CML) is characterized by BCR-ABL1 mutation. A number of research studies have published reports of concomitant JAK2-V617F mutation in BCR-ABL positive Chronic Myeloid Leukaemia.
Nasir Ahmad, Saima Qayum, Abid Jameel, Asif Ali, Sami Siraj, Johar Ali, Yasar Mehmood Yousafzai   +6 more
doaj   +1 more source

A Comparison of Bone Marrow Morphology and Peripheral Blood Findings in Low and High Level JAK2 V617F Allele Burden

Diagnostics, 2023
Cases with low level JAK2 V617F mutations are increasingly detected; however, the clinical interpretation of the low allele JAK2 burden may be challenging.
Emina Babarović, Blažen Marijić, Luka Vranić, Josipa Ban, Toni Valković, Ita Hadžisejdić   +5 more
doaj   +1 more source

Frequency and characteristics of the V617F mutation in 23 cerebral venous sinus thrombosis patients with thrombocytosis

Journal of International Medical Research, 2020
Objective To analyse the frequency and characteristics of the Janus kinase 2 ( JAK2) V617F mutation in patients with cerebral venous sinus thrombosis (CVST) with thrombocytosis.
Qiang Ma
doaj   +1 more source

Analysis of JAK2 V617F mutation in Tunisian patients with myeloproliferative neoplasms

European Journal of Inflammation, 2021
We aimed to investigate the prevalence of the JAK2 V617F mutation in Tunisian patients with myeloproliferative neoplasms (MPN) and to look for possible associations with diseases’ presentation. In this context, JAK2 V617F polymorphism was detected by PCR-
Soumaya Chadi, Tarak Dhaouadi, Imen Sfar, Hela Baccouche, Rym Nabli, Neila Ben Romdhane, Taïeb Ben Abdallah, Yousr Gorgi   +7 more
doaj   +1 more source