Results 41 to 50 of about 577,308 (213)

Allelic expression imbalance of JAK2 V617F mutation in BCR-ABL negative myeloproliferative neoplasms. [PDF]

PLoS ONE, 2013
The discovery of a single point mutation in the JAK2 gene in patients with BCR/ABL-negative myeloproliferative neoplasms (MPNs) has not only brought new insights and pathogenesis, but also has made the diagnosis of MPNs much easier.
Hye-Ran Kim, Hyun-Jung Choi, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Myung-Geun Shin   +7 more
doaj   +1 more source

Molecular screening for an underlying myeloproliferative neoplasm in rheumatology patients

The Turkish Journal of Gastroenterology, 2022
The hematological manifestations of rheumatic diseases are varied with therapeutic agents also capable of inducing hematological abnormalities such as cytopenias.[1] Some of these hematological features can mimic those of the myeloproliferative ...
Stephen Langabeer
doaj  

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

, 2010
The JAK2 V617F mutation is found in most patients with a myeloproliferative neoplasm and is sufficient to produce a myeloproliferative phenotype in murine retroviral transplantation or transgenic models.
Anand, Shubha, Chen, Edwin, Spensberger, Dominik, Watson, Steve P., Campbell, P.J., Scott, Linda M., Huntly, Brian J.P., Huntly, B.J., Erber, Wendy N., Chen, E., Green, AR, Ahn, Jong Sook, Beer, PA, Campbell, PJ, Huntly, Brian J. P., Campbell, Peter J., Anand, S., Forrai, A, Spensberger, D, Scott, LM, Watson, Steve; id_orcid, Li, J., Ghevaert, Cedric, Ottersbach, K., Forrai, A., Green, Anthony R., Liu, P., Erber, W.N., Li, J, Liu, P, Ahn, JS, Ghevaert, C., Ottersbach, Katrin, Watson, S.P., Chen, E, Ahn, J.S., Scott, L.M., Ferreira, R, Forrai, Ariel, Green, A.R., Erber, WN, Beer, P.A., Ghevaert, C, Ottersbach, K, Anand, S, Li, Juan, Beer, Philip A., Ferreira, R., Spensberger, D., Liu, Pentao, Ferreira, Rita, Huntly, BJP   +51 more
core   +1 more source

The presence of JAK2V617F mutation in the patients with MPNs.

, 2015
* JAK2V617F mutation is presented as the percentage of JAK2V617F mutation with respect to the entire JAK2 genome. The threshold of JAK2V617F positivity is defined as 1% in AS-PCR.The presence of JAK2V617F mutation in the patients with MPNs.
Kochi Takahashi (707796), Yoko Edahiro (382799), Miyuki Tsutsui (382801), Marito Araki (382793), Norio Komatsu (382804), Soji Morishita (382795), Yoshitaka Sunami (382792), Akimichi Ohsaka (382803), Satoshi Tsuneda (45702), Yumi Hironaka (382794)   +9 more
core   +1 more source

A new case of dic(1;15) in essential thrombocythaemia with JAK2 V617F mutation [PDF]

, 2012
Case report of a translocation : A new case of dic(1;15) in essential thrombocythaemia with JAK2 V617F ...
Mangueira, CLP, Rodrigues, Pereira Velloso ED, Aquilino, Oliveira D, de Sousa, Misael NC, Alonso, Ratis C, Kishimoto, RK, de Campos, Guerra JC   +6 more
core   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Diagnostic value of the JAK2 V617F mutation for latent chronic myeloproliferative disorders in patients with budd-chiari syndrome and/or portal vein thrombosis

The Turkish Journal of Gastroenterology, 2015
Background/Aims: The diagnosis of an underlying myeloproliferative neoplasm (MPN) is often problematic in patients with Budd Chiari syndrome (BCS) or portal vein thrombosis (PVT).
Süleyman Karaköse, Nevin Oruç, Melia Zengin, Ulus Salih Akarca, Galip Ersöz   +4 more
doaj   +1 more source

Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms.

PLoS ONE, 2021
Myeloproliferative neoplasms (MPNs) cause the over-production of blood cells such as erythrocytes (polycythemia vera) or platelets (essential thrombocytosis).
Ron Baik, Stacia K Wyman, Shaheen Kabir, Jacob E Corn   +3 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The JAK2 V617F mutation in isolated neutropenia

EXCLI journal, 2018
EXCLI Journal; 17:Doc1; ISSN 1611 ...
openaire   +3 more sources