Results 41 to 50 of about 5,550 (180)

A facile and high-sensitive bio-sensing of the V617F mutation in JAK2 gene by GSH-CdTe-QDs FRET-based sensor

Heliyon, 2022
This study aimed to directly detect the V617F point mutation of the Janus kinase 2 (JAK2) gene in the target DNA using a FRET-based biosensor. The water-soluble GSH-CdTe-QDs were synthesized by a one-step process, then GSH-QD conjugated to the termini ...
Fatemeh Hakimi, Maryam Khoshkam, Somayeh Sadighian, Ali Ramazani   +3 more
doaj   +1 more source

The Effect of Polycythemia Vera on Pregnancy Complications. The Analysis of an American Population Database With Over 9 Million Deliveries

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Polycythemia Vera (PV) is characterized by overproduction of erythrocytes, leading to a hypercoagulable state. Evidence regarding associations between PV and pregnancy outcomes is limited. The aim of our study was to provide robust evidence regarding the prevalence of pregnancy complications in women with PV.
Noah Margolese, Sarah Al‐Rayes, Shaonie Ton‐Leclerc, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +5 more
wiley   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Persistent Erythrocytosis in a Dog With a Spinal Sclerosing Paraganglioma

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 7‐year‐old, male, castrated, mixed‐breed dog presented with right pelvic limb lameness and pain on posturing to defecate that began 1.5 years prior to presentation. Radiographs taken 8 months prior to presentation showed a small lytic lesion of the L6 vertebral body, and CBCs showed a persistently increased hematocrit (HCT) for at least 2 ...
Samuel V. Neal, Samantha L. Sommer, Sarah Golconda, Eric T. Hostnik, Russell Sakacs, Janice Park, Ashley Potts, Ronaldo C. da Costa, Christopher Premanandan, Kara Corps, Sanggu Kim, Maxey L. Wellman   +11 more
wiley   +1 more source

ASSOCIATION OF OBESITY WITH JAK2 V617F GENE MUTATION IN RECURRENT PREGNANCY LOSS [PDF]

Journal of Environmental Science, 2016
Maternal obesity is one of the factors that have a role in recurrent pregnancy loss ( RPL) . Increased rate of fetal loss in obese pregnant women might be due the mutation in Janus kinase2 gene (V617F).
Shaker, Mai, Awadallah, Hala, Gaber, kh., Amr, khalda   +3 more
doaj   +1 more source

Clonal Hematopoiesis in Colorectal Cancer: Mechanisms and Implications

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Clonal hematopoiesis (CH) arises from the expansion of hematopoietic stem and progenitor cells bearing somatic mutations, often in genes linked to epigenetic regulation and inflammation. Once considered a benign age‐related phenomenon, CH has gained increasing attention for its potential to influence cancer biology beyond hematologic ...
Chenyue Xia, Yi Lu, Jinhui Gu
wiley   +1 more source

Tyrosine kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias

Haematologica, 2007
We investigated a large number of acute myeloid leukemia (AML) samples (n=959) for the presence of the JAK2 V617F mutation. We found a low incidence of the mutation in these AML samples (1%). JAK2 V617F mutations clustered in AML samples with an aberrant
Thomas Illmer, Markus Schaich, Gerhard Ehninger, Christian Thiede   +3 more
doaj   +1 more source

A Therapeutic Dilemma: Catastrophic ST‐Elevation Myocardial Infarction Following Antiplatelet Therapy Interruption in a Patient With JAK2‐Positive Polycythemia Vera

Clinical Case Reports, Volume 14, Issue 8, August 2026.
Premature interruption of dual antiplatelet therapy in a patient with polycythemia vera and clinically suspected acquired von Willebrand syndrome triggered catastrophic recurrent stent thrombosis, whereas perioperative bridging with eptifibatide enabled safe surgery. ABSTRACT Polycythemia vera is associated with a thrombotic–hemorrhagic paradox.
Behrouz zarei, Amirhossein Rezaei Latifi, Mohammad Salari   +2 more
wiley   +1 more source

P49

EJC Supplements, 2015
Myelofibrosis with myeloid metaplasia is chronic mieloproliferative disease with ineffective erythropoiesis, dysplastic-megakaryocyte hyperplasia, and an increase in the ratio of immature granulocytes to total granulocytes.
A. Silyutina, S. Zhuk, P. Butylin, A. Zaritskey   +3 more
doaj   +1 more source

From Basics to Benchmarks: Evaluating Sample Adequacy, PD‐L1 Expression, and Molecular Profiling in Effusion Samples of Lung Adenocarcinoma

Diagnostic Cytopathology, Volume 54, Issue 8, Page 547-555, August 2026.
ABSTRACT Introduction Lung adenocarcinoma commonly causes malignant pleural effusion (MPE), a condition with poor prognosis and limited treatment options. Pleural effusion specimens offer a minimally invasive source for diagnosis and molecular testing.
Harpreet Virk, Claire Michael, Keri Ann Pfeil, Navid Sadri, Omid Savari, Aparna Harbhajanka   +5 more
wiley   +1 more source