Results 61 to 70 of about 577,308 (213)

JAK2 V617F Mutation Status of 232 Patients Diagnosed With Chronic Myeloproliferative Neoplasms

, 2014
The aim of this study was to investigate the presence of Janus kinase 2 (JAK2) V617F mutation in patients with BCR-ABL negative chronic myeloproliferative neoplasms (CMPNs) in our center.
Savasoglu, Kaan, ALACACIOĞLU, İNCİ, Calli, Aylin Orgen, Mutlu, Belgin Berber, Aksun, Saliha, Bener, Sadi, Kucukzeybek, Betul Bolat, Payzin, Kadriye Bahriye, Ozdemirkiran, Fusun   +8 more
core   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, Volume 209, Issue 4, Page 1450-1468, October 2026.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

JAK2(V617F) Mutation Is Not Associated with Thrombosis in Behcet Syndrome

, 2012
WOS: 000305797100012PubMed ID: 22203033The Janus kinase 2(V617F) (JAK2(V617F)) mutation is an acquired genetic defect that is considered to enhance thrombosis in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs).
Bilgen, Hulya, Hatemi, Gulen, Soysal, Teoman, Ar, M. Cem, Ekizoglu, Seda, Yazici, Hasan, Buyru, A. Nur, Ulku, Birsen, Sacli, Sevgi, Ar, Muhlis Cem   +9 more
core   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Tyrosine kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias

Haematologica, 2007
We investigated a large number of acute myeloid leukemia (AML) samples (n=959) for the presence of the JAK2 V617F mutation. We found a low incidence of the mutation in these AML samples (1%). JAK2 V617F mutations clustered in AML samples with an aberrant
Thomas Illmer, Markus Schaich, Gerhard Ehninger, Christian Thiede   +3 more
doaj   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia‐Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Mariagiovanna Ballato, Vincenzo Fiorentino, Gabriele Ricciardi, Pietro Tralongo, Emanuela Germanà, Alessandro Allegra, Fabio Stagno, Guido Fadda, Maurizio Martini   +8 more
wiley   +1 more source

ASSOCIATION OF OBESITY WITH JAK2 V617F GENE MUTATION IN RECURRENT PREGNANCY LOSS [PDF]

Journal of Environmental Science, 2016
Maternal obesity is one of the factors that have a role in recurrent pregnancy loss ( RPL) . Increased rate of fetal loss in obese pregnant women might be due the mutation in Janus kinase2 gene (V617F).
Shaker, Mai, Awadallah, Hala, Gaber, kh., Amr, khalda   +3 more
doaj   +1 more source

Diagnosis and Management of Polycythemia Vera Complicated by Cerebral Infarction and Subdural Hematoma: A Case Report

iLABMED, Volume 4, Issue 3, Page 197-203, September 2026.
A 70‐year‐old man with recurrent cerebral infarctions, a subdural hematoma, and atherosclerotic disease involving multiple extracranial vascular territories was subsequently diagnosed with polycythemia vera (PV). In patients with recurrent cerebrovascular events accompanied by otherwise unexplained persistent erythrocytosis, JAK2 mutation testing and ...
Hui Zhao, Jie Feng, Yu Jing, Wei Xie, Yingjiao Sha, Yanhong Gao   +5 more
wiley   +1 more source

JAK2 V617F mutation is a rare event in juvenile myelomonocytic leukemia [PDF]

Leukemia, 2006
N ...
Zecca, M, Bergamaschi, G, Kratz, C, Bergsträßer, E, Danesino, C, De Filippi, P, Hasle, H, Lisini, D, Locatelli, F, Pession, A, Sainati, L, Starý, J, Trebo, M, van den Heuvel-Eibrink, M, Wójcik, D, Niemeyer, C M, NA, NA   +16 more
openaire   +6 more sources

P49

EJC Supplements, 2015
Myelofibrosis with myeloid metaplasia is chronic mieloproliferative disease with ineffective erythropoiesis, dysplastic-megakaryocyte hyperplasia, and an increase in the ratio of immature granulocytes to total granulocytes.
A. Silyutina, S. Zhuk, P. Butylin, A. Zaritskey   +3 more
doaj   +1 more source