Results 51 to 60 of about 577,308 (213)

Estimated pulse wave velocity as a marker of major adverse cardiovascular events in essential thrombocythaemia and polycythaemia vera

British Journal of Haematology, EarlyView.
In patients with essential thrombocythaemia or polycythaemia vera, higher estimated pulse wave velocity (ePWV) was independently associated with major adverse cardiovascular events, while its relationship with overall survival was largely age‐driven.
Alessandro Costa, Olga Mulas, Federica Pilo, Eleonora Atzeni, Martina Pettinau, Daniela Mantovani, Giovanni Caocci   +6 more
wiley   +1 more source

Atypical Myocardial Infarction with Apical Thrombus and Systemic Embolism: A Rare Presentation of Likely JAK2 V617F-Positive Myeloproliferative Neoplasm

Case Reports in Oncological Medicine, 2020
A few types of myeloproliferative neoplasms may be significant for Janus-associated kinase 2 mutation, JAK2 V617F, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
Muhammed Atere, Rana Al-Zakhari, Jennifer Collins, Francesco Rotatori, Lloyd Muzangwa   +4 more
doaj   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation

Haematologica, 2013
Myeloproliferative disorders are associated with increased risk of thrombosis and vascular complications. The pathogenesis of these complications is not completely known.
Margarita Hurtado-Nedelec, Marie-José Csillag-Grange, Tarek Boussetta, Sahra Amel Belambri, Michèle Fay, Bruno Cassinat, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, Jamel El-Benna   +8 more
doaj   +1 more source

PCR-HRM for Detecting JAK2V617F Gene Mutation: Is It a Sensitive Assay?

Basic & Clinical Cancer Research, 2020
Background: A substitution of G to T at nucleotide 1849 in exon 14 of the Janus kinase2 (JAK2) gene is recognized to MPNs disorders. Based on WHO guidelines detection of the mutation is very important to confirm the disease in the suspected patients ...
Mitra Rezaei, Mihan PourAbdollah Toutkaboni, Babak Salimi, Sharareh Seifi, Fatemeh Maryam Sheikholeslami   +4 more
doaj   +1 more source

Evaluation of the JAK2-V617F gene mutation in Turkish patients with essential thrombocythemia and polycythemia vera

, 2012
An activating mutation of Janus kinase 2 (JAK2-V617F) was previously described in chronic myeloproliferative disorders (MPD). In previously published studies, the frequency of the JAK2-V617F mutation was determined to be 80-90 % for patients with ...

core   +1 more source

The Effect of Polycythemia Vera on Pregnancy Complications. The Analysis of an American Population Database With Over 9 Million Deliveries

European Journal of Haematology, Volume 117, Issue 5, Page 1249-1257, November 2026.
ABSTRACT Objectives Polycythemia Vera (PV) is characterized by overproduction of erythrocytes, leading to a hypercoagulable state. Evidence regarding associations between PV and pregnancy outcomes is limited. The aim of our study was to provide robust evidence regarding the prevalence of pregnancy complications in women with PV.
Noah Margolese, Sarah Al‐Rayes, Shaonie Ton‐Leclerc, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +5 more
wiley   +1 more source

Is Low Positive JAK2 V617F Mutation Test Result Clinically Significant?: Multi-Institutional Study

, 2015
OBJECTIVES: Acquired somatic mutation Janus kinase 2 (JAK2) V617F is associated with various myeloproliferative neoplasms (MPN). Allele-specific real-time polymerase chain reaction has been widely adopted to detect mutation; however, the utility of low ...
Wu, X., Laser, J., Peker, D., Lee, J. W., Spitzer, S. G., Harada, S., Reddy, V. V., Xiaojun Wu, Jordan Laser, Silvia G. Spitzer, Deniz Peker, Vishnu V.B. Reddy, Joong Won Lee, Shuko Harada   +13 more
core   +1 more source

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.

, 2013
peer reviewedThe identification of a constitutively active JAK2 mutant, namely JAK2-V617F, was a milestone in the understanding of Philadelphia chromosome-negative myeloproliferative neoplasms.
BEHRMANN, Iris, Schaper, Fred, ROLVERING, Catherine, HAAN, Serge, Eulenfeld, Rene, Wolf, Alexandra, Gäbler, Karoline, Denecke, Bernd, HAAN, Claude   +8 more
core   +1 more source

A facile and high-sensitive bio-sensing of the V617F mutation in JAK2 gene by GSH-CdTe-QDs FRET-based sensor

Heliyon, 2022
This study aimed to directly detect the V617F point mutation of the Janus kinase 2 (JAK2) gene in the target DNA using a FRET-based biosensor. The water-soluble GSH-CdTe-QDs were synthesized by a one-step process, then GSH-QD conjugated to the termini ...
Fatemeh Hakimi, Maryam Khoshkam, Somayeh Sadighian, Ali Ramazani   +3 more
doaj   +1 more source