Results 11 to 20 of about 577,308 (213)

JAK2 (V617F) mutation in healthy individuals

British Journal of Haematology, 2007
Here, we report a study of JAK2 (V617F) mutation in 75 normal subjects referred to the Outpatient Section of the Department of Haematology of Pavia. These healthy individuals (aged from 18 to 79 years) displayed a normal blood cell count without spleen ...
RUMI, ELISA, CAZZOLA, MARIO, Lazzarino M, Rumi E, Pietra D, LAZZARINO, MARIO, PASSAMONTI, FRANCESCO, Cazzola M.   +7 more
core   +6 more sources

Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status [PDF]

Haematologica, 2007
We compared the laboratory and clinical findings of 179 patients with essential thrombocythemia (ET) and 77 with polycythemia vera (PV) classified according to the presence of the JAK2 V617F mutation.
Guido Finazzi, Alessandro Rambaldi, Vittoria Guerini, Alessandra Carobbo, Tiziano Barbui   +4 more
doaj   +4 more sources

The JAK2 V617F mutation in patients with cerebral venous thrombosis. [PDF]

Journal of Thrombosis and Haemostasis, 2012
Background: It is currently unclear whether or not cerebral venous thrombosis, such as splanchnic venous thrombosis, can be the first manifestation of an underlying myeloproliferative neoplasm.
Biguzzi E, Franchi F, Gianniello F, CAZZOLA, MARIO, Bucciarelli P, Pietra D, Mannucci PM, Martinelli I., Passamonti SM   +8 more
core   +4 more sources

Abdominal venous thrombosis presenting in myeloproliferative neoplasm with JAK2 V617F mutation: a case report [PDF]

Journal of Medical Case Reports, 2012
Introduction An unprovoked thombotic event in a patient is cause for further evaluation of an underlying hypercoaguable state. The investigation should include a thorough search, including checking for a variety of known inherited and acquired ...
Pemmaraju Naveen, Hamilton James, Cameron Andrew M, Sisson Stephen, Moliterno Alison R   +4 more
doaj   +3 more sources

Occurrence of the JAK2 V617F mutation in the Budd–Chiari Syndrome

Blood Coagulation & Fibrinolysis, 2008
Myeloproliferative diseases represent a major risk factor for Budd-Chiari syndrome. In 32 patients with Budd-Chiari syndrome, the JAK2 V617F mutation was detected, in heterozygous state, in 11 individuals (34.4%; 95% confidence interval: 18.6-53.2 ...
GALLONE, Anna, M. A. GUARDASCIONE AND M. MARGAGLIONE, D. COLAIZZO, L. AMITRANO, E. GRANDONE, G. L. TISCIA, L. IANNACCONE   +6 more
core   +3 more sources

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations

Blood, 2008
We studied the lineage distribution of JAK2 mutations in peripheral blood of 8 polycythemia vera (PV) patients with exon 12 mutations and in 21 PV patients with JAK2-V617F.
Theocharides, Alexandre, Kralovics, Robert, Li, Sai, De Libero, Gennaro, Skoda, Radek C., Gisslinger, Heinz, Li S, Theocharides A, Kralovics R, Gisslinger H, Skoda RC, De Libero G   +11 more
core   +5 more sources

Hypereosinophilic Syndrome with Endomyocarditis: Identification by Next-Generation Sequencing of the JAK2-V617F Mutation. [PDF]

Eur J Rheumatol, 2023
Hypereosinophilic syndrome requires a peripheral absolute eosinophil count of ≥1.5 × 109 /L with clinical manifestations attributable to peripheral or tissue hypereosinophilia.
Tesfamicael R, Aung T, Domin Lee T, Brahn E.   +3 more
europepmc   +2 more sources

JAK2-V617F mutation among blood donors: A meta-analysis. [PDF]

Saudi Med J
To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial.
Alsharif MH, Mansory EM, Alharazi AA, Badawi MA.   +3 more
europepmc   +3 more sources

Extensive Cerebral Venous Sinus Thrombosis With Obstructive Hydrocephalus in a Young Female With Underlying Essential Thrombocythemia: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Persistent symptoms suggestive of idiopathic intracranial hypertension despite standard therapy should prompt urgent neuroimaging to exclude cerebral venous sinus thrombosis. When CVST is confirmed without an obvious provoking factor, evaluation for underlying myeloproliferative neoplasms, including JAK2‐positive essential thrombocythemia, is ...
Nafea S, Farooq T, Taher MA, Barros A, Soe KN, Ali F, Thomas K.   +6 more
europepmc   +2 more sources

JAK2 V617F MUTATION SCANNING IN PATIENTS WITH ADRENAL INCIDENTALOMA. [PDF]

Acta Endocrinol (Buchar), 2017
Adrenal incidentaloma are lesions which are stated incidentally by imaging methods when there is no suspicion of any disease in adrenal gland. Inappropriate Jak2 signaling causes some solid and hematological malignancies. But the Jak2 mutation has not been previously evaluated with regard to adrenal tumors.
Ekinci F, Soyaltin UE, Kutbay YB, Yaşar HY, Demirci Yıldırım T, Akar H.   +5 more
europepmc   +5 more sources