Results 141 to 150 of about 1,274 (184)

Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports. [PDF]

World J Clin Cases
Ha Y, Kim JH, Kim J, Kwon H.
europepmc   +1 more source

Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells. [PDF]

Sci Rep
Baek A, Baek D, Kim SH, Kim J, Notario GR, Lee DW, Kim HJ, Cho SR.   +7 more
europepmc   +1 more source

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Effect of polydeoxyribonucleotides on human fibroblasts in primary culture

Cell Biochemistry and Function, 1999
The effects of a mixture of oligo- and polydeoxyribonucleotides (PDRN) on the growth and protein secretion of cultured human skin fibroblasts were investigated. Both intact and DNAase-digested PDRN stimulated cell proliferation to a similar extent.
Patrizia Sini, Antonella Denti, Giulia Cattarini, Mario Daglio, TIRA, MARIA ENRICA, BALDUINI, CESARE   +5 more
exaly   +3 more sources

Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides

Investigational New Drugs, 2023
One of the features that differentiate cancer cells is their increased proliferation rate, which creates an opportunity for general anti-tumor therapy directed against the elevated activity of replicative apparatus in tumor cells. Besides DNA synthesis, successful genome replication requires the reparation of the newly synthesized DNA.
Fursov Valentin V., Vedenkin Alexander S., Stovbun Sergey V., Bukhvostov Alexander A, Zlenko Dmitry V., Stovbun Ivan S., Silnikov Vladimir N., Kuznetsov Dmitry A.   +7 more
openaire   +3 more sources

Viscoelastic interactions between polydeoxyribonucleotide and ophthalmic excipients

Drug Development and Industrial Pharmacy, 2015
This study investigated the interaction between polydeoxyribonucleotide (PDRN) and several ionic and nonionic isotonic agents, thickeners and a preservative that were employed as excipients in ophthalmic preparations. Interaction of each individual excipient and PDRN aqueous solution was evaluated by analyzing their rheological properties.
Iksoo, Kim, Hyeongmin, Kim, Kyunghee, Park, Sandeep, Karki, Prakash, Khadka, Kanghee, Jo, Seong Yeon, Kim, Jieun, Ro, Jaehwi, Lee   +8 more
openaire   +2 more sources

The synthesis of 5′ thioanalogs of polydeoxyribonucleotides

Biochemical and Biophysical Research Communications, 1970
Abstract Oligo 5′-thiodeoxythymidylates and oligo 5′-thiodeoxyadenylates were prepared via displacement of tosylates by thiophosphate mono- and diesters. The 5′ ends contain O-tosyl or S-phosphoryl groups, while the 3′ ends terminate in deoxythymidine.
J, Nagyvary, S, Chladek, J, Roe
openaire   +2 more sources

Polydeoxyribonucleotide Treatment in Genital Lichen Sclerosus in Males

Urologia Internationalis, 2016
It has been reported that treatment with polydeoxyribonucleotide (PDRN) in males affected by lichen sclerosus significantly improves the overall conditions of treated patients. It confirms that PDRN has a potent cytoprotective action as in other pathological conditions.
ARENA, SALVATORE, ROMEO, Carmelo
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Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival

Aesthetic Plastic Surgery, 2019
A composite graft is considered the best choice for facial reconstruction because of proper texture, color, and simple surgical techniques. However, due to revascularization by the bridging phenomenon, it has limitations with unpredictable survival rates and can be applied only to small defects. Polydeoxyribonucleotide (PDRN) plays an important role in
Jae Won Heo, Yong Hun Kim, Eon Su Kim, Sug Won Kim, Jiye Kim   +4 more
openaire   +2 more sources

Thienocoumarin derivatives: interaction with nucleic acids and synthetic polydeoxyribonucleotides

Journal of Photochemistry and Photobiology B: Biology, 2000
This paper reports the photobiological properties of two new thienocoumarins, 4,6,9-trimethyl-2H-thieno[3,2-g]-1-benzopyran-2-one (compound I) and the 6,9-dimethyl-4-methoxymethyl-2H-thieno[3,2-g]-1-benzopyran-2-one (compound II). Cell growth inhibition studies have revealed significant antiproliferative potency on human tumor cell lines.
GIA, ORNELLA MARIA, DALLA VIA, LISA, MARCIANI MAGNO, SEBASTIANO, G. ANGELINI, A. MARGONELLI, P. RODIGHIERO   +5 more
openaire   +5 more sources

Polydeoxyribonucleotides Antagonize Nucleoside Analogues in Cancer Therapy.

Blood, 2006
Abstract Background: In the past years, an increasing number of nucleic acid based drug candidates (e.g. antisense oligonucleotides, aptamers, ribozymes, RNA interference) have been identified and already tested in clinical trials.
Raymund Buhmann, Hans-Jochem Kolb, Zhizhe Chen, Simone Tank, Ingo Steinmann, Ting Yang   +5 more
openaire   +1 more source