Results 61 to 70 of about 1,274 (184)

Nucleic Acid-Based Therapeutics for Periodontal Tissue Regeneration: A Comprehensive Review

Applied Sciences
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are biologically active DNA-derived polymers with emerging applications in regenerative dentistry. Acting through adenosine A2A receptor activation and modulation of inflammatory responses, these
Jwa-Young Kim, Min-Ho Hong, Seong-Gon Kim, Umberto Garagiola   +3 more
doaj   +1 more source

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, Volume 38, Issue 11, 20 February 2026.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

Effects of Na-DNA mouthwash solutions on oral soft tissues. A bioreactor-based reconstituted human oral epithelium model [PDF]

, 2020
Purpose: To investigate whether the addition of sodium-DNA (Na-DNA) to chlorhexidine (CHX)-containing mouthwash influenced morphology and viability of a reconstituted human oral epithelium (ROE), and protects ROE against oxidative stress.
Brambilla, Eugenio, Conte, Vincenzo, Garcia-Godoy, Franklin, Ionescu, Andrei C, Procacci, Patrizia, Vezzoli, Elena   +5 more
core  

First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide

Current Issues in Molecular Biology
Polydeoxyribonucleotide (PDRN) has emerged as a potent bioactive compound with proven efficacy in wound healing, tissue regeneration, and anti-inflammatory applications and is predominantly derived from salmonid gonads. However, this study presents a groundbreaking advancement by successfully extracting and characterizing PDRN from microbial sources ...
Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo   +6 more
openaire   +2 more sources

The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre-clinical in vivo study [PDF]

AimThis study investigated the adjunctive effect of polydeoxyribonucleotide (PDRN) on bone formation in alveolar ridge preservation (ARP) sockets.Materials and MethodsBoth mandibular second, third and fourth premolars of eight beagle dogs were randomly ...
Ko Young-Chang, Koo Ki-Tae, Lee Jungwon, Lee Yong-Moo, Seol Yang-Jo, Urbán István András   +5 more
core   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Ultrasound-Guided Prolotherapy with Polydeoxyribonucleotide for Painful Rotator Cuff Tendinopathy [PDF]

Pain Research and Management, 2018
Background. Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical ...
Kyoungho Ryu, Dongchan Ko, Goeun Lim, Eugene Kim, Sung Hyun Lee   +4 more
openaire   +3 more sources

Histological Outcomes of Root Coverage Procedures: A Systematic Review With Meta‐Analysis

Journal of Periodontal Research, Volume 61, Issue 1, Page 9-29, January 2026.
This systematic review summarizes the current preclinical and clinical evidence for the histological outcomes of root coverage procedures, while also highlighting limitations of existing data, its implications for clinical practice, and suggestions for future research.
Siddharth Shanbhag, Ida Haukåen Stødle, Stein Atle Lie, Mariano Sanz, Anders Verket   +4 more
wiley   +1 more source

A novel method to encapsulate polydeoxyribonucleotides extracted from trout into exosomes and applications in skin recovery

BMC Biotechnology
Polydeoxyribonucleotide (PDRN), a DNA polymer derived from salmonid tissue, is widely used in regenerative dermatology but its topical application is limited by poor stability and delivery efficiency.
Yunhee Chang, Jun-Young Park, Dasom Hwang, Min Tae Kim, Seyeon Yoon, Seung-Hak Cho   +5 more
doaj   +1 more source

Refractory Alopecia Areata of the Beard: Novel Improvement Through Exosome Therapy With Signs of Hair Repigmentation

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Exosome injections derived from human umbilical cord, with or without polydeoxyribonucleotide, induced robust regrowth, repigmentation of previously white beard hairs, and scar improvement in a 35‐year‐old man with refractory alopecia areata of the beard, suggesting a promising minimally invasive regenerative option.
Asem Shadid, Khalid Nabil Nagshabandi, Danah K. AlRuhaimi, Abdullah Al‐Omair, Abdulaziz Alsadhan   +4 more
wiley   +1 more source