Results 41 to 50 of about 1,274 (184)

The use of defibrotide in blood and marrow transplantation

open access: yesBlood Advances, 2018
: Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of conditioning during hematopoietic stem cell transplantation (HSCT) or chemotherapy without HSCT, with a historically reported ...
Paul G. Richardson   +3 more
doaj   +1 more source

Effects of topical polydeoxyribonucleotide on radiation-induced oral mucositis [PDF]

open access: yesTechnical Innovations & Patient Support in Radiation Oncology, 2018
Oral mucositis, the most common adverse effect of radiotherapy (RT) and/or chemotherapy is observed in almost 97% of patients with head and neck cancer. Although several agents like corticosteroids, lidocaine and vitamins are available for its prevention or management, results are often disappointing.
Podlesko A. M.   +9 more
openaire   +4 more sources

A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides

open access: yesScientia Pharmaceutica, 2019
Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20−200 n) and the same lengths routine poly(dNTP) and poly(NTP) species were tested for their impact on catalytic activities of β-like DNA polymerases
Sergey Stovbun   +4 more
doaj   +1 more source

Torsion and bending of nucleic acids studied by subnanosecond time-resolved fluorescence depolarization of intercalated dyes [PDF]

open access: yes, 1982
Subnanosecond time‐resolved fluorescence depolarization has been used to monitor the reorientation of ethidium bromide intercalated in native DNA, synthetic polynucleotide complexes, and in supercoiled plasmid DNA.
Millar, D. P.   +2 more
core  

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

open access: yesInterdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi   +6 more
wiley   +1 more source

Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms [PDF]

open access: yes, 2020
Redox cycling of extracellular electron shuttles can enable the metabolic activity of subpopulations within multicellular bacterial biofilms that lack direct access to electron acceptors or donors.
Barton, Jacqueline K.   +8 more
core  

Microbial sources of exocellular DNA in the ocean [PDF]

open access: yes, 2022
© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Linney, M. D., Eppley, J. M., Romano, A. E., Luo, E., DeLong, E. F., & Karl, D. M.
DeLong, Edward F.   +5 more
core   +1 more source

Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

open access: yesOral Diseases, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the most effective minimally invasive intra‐articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement.
Mateus Gaya dos Santos   +5 more
wiley   +1 more source

Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action

open access: yesApplied Sciences
Polydeoxyribonucleotides (PDRN), highly purified DNA-derived polymers, were approved by the Italian Medicines Agency (AIFA) in 1994 to treat superficial wounds, skin ulcers, and dystrophic connective tissue disorders.
Seokmuk Park   +6 more
doaj   +1 more source

A Deoxyribonuclease from Calf Spleen: I Purification and Properties [PDF]

open access: yes, 1957
The deoxyribonucleases1 of animal tissues are of two types which are readily distinguishable by the conditions necessary for activity on their substrate, DNA.
Koerner, James F., Sinsheimer, Robert L.
core  

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