Results 141 to 150 of about 44,217 (244)

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Polymer chain generation for coarse-grained models using radical-like polymerization

, 2007
An innovative method is proposed to generate configurations of coarse grained models for polymer melts. This method, largely inspired by chemical ``radical polymerization'', is divided in three stages: (i) nucleation of radicals (reacting molecules ...
Barrat, Jena-Louis, Lame, Olivier, Leonforte, Fabien, Perez, Michel   +3 more
core  

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

The Cytotoxicity, Characteristics, and Optimization of Insulin-loaded Nanoparticles

Orbital: The Electronic Journal of Chemistry, 2017
Controlled release systems for insulin are frequent subjects of research, because it is rapidly degraded by proteolytic enzymes in the gastrointestinal tract and minimally absorbed after oral administration.
Yasemin Budama-Kilinc, Rabia Cakir-Koc, Ozlem Horzum-Bayir   +2 more
doaj  

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded with Doxorubicin on MCF-7 Cells

مجله دانشکده پزشکی اصفهان, 2013
Background: Doxorubicin is used for treatment of different types of cancer including breast cancer. However, there are various side effects such as cardiotoxicity.
Jaleh Varshosaz, Farshid Hassanzadeh, Hojjat Sadeghi Aliabadi, Zahra Larian   +3 more
doaj  

Synthetic biology design principles enable efficient bioproduction of Heparosan with low polydispersion index for the biomedical industry

Abstract Heparosan, a natural polymer with unique chemical and biological properties, holds great promise for various biomedical applications. Of particular interest is the production of low molecular weight and low polydisperse heparosan polymers, which offer enhanced functionality and suitability for therapeutic and diagnostic purposes ...
Yadira Boada, Marcelo Flores Vázquez, Marco Córdova, Francisco J Flores, Alejandro Vignoni   +4 more
openaire   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Synthetic biology design principles enable efficient bioproduction of Heparosan with low molecular weight and low polydispersion index for the biomedical industry

Synthetic Biology
Abstract Heparosan is a natural polymer with unique chemical and biological properties, that holds great promise for biomedical applications. The molecular weight (Mw) and polydispersion index (PDI) are critical factors influencing the performance of heparosan-based materials.
Yadira Boada, Marcelo Flores, Martin Stiebritz, Marco Córdova, Francisco Flores, Alejandro Vignoni   +5 more
openaire   +2 more sources