Results 131 to 140 of about 16,341 (199)
Functional and Structural Studies on the Esperamicin Thioesterase and Progress toward Understanding Enediyne Core Biosynthesis. [PDF]
J Nat ProdHankore ED +11 more
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Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus.
Chem Commun (Camb)Prasongpholchai P +7 more
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The Dentist in Palliative Care: Addressing Oral Health for Holistic End-of-Life Support.
J Pharm Bioallied SciTripathi P +5 more
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Biomimetic polyene cyclizations
Bioorganic Chemistry, 1976AbstractCertain polyenic substances having trans olefinic bonds in a 1,5 relationship can be induced to undergo stereospecific, non‐enzymic, cationic cyclization to give polycyclic products with all‐trans (“natural”) configuration. These transformations appear to mimic in principle the biogenetic conversion of squalene into polycyclic triterpenoids ...
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Organic Letters, 2012
A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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Enantioselective polyene cyclizations
Organic & Biomolecular Chemistry, 2016A comprehensive review covering the field of enantioselective polyene cyclizations.
Chad N, Ungarean +2 more
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2005
Polyene antibiotics (i.e., amphotericin B and nystatin) have been incorporated into lipid-based delivery systems to decrease their toxicity and enhance their therapeutic index, the most common being liposomes. This chapter describes the protocols for preparing liposomal amphotericin B and determining the efficacy and toxicity of the formulations in ...
Agatha W K, Ng +2 more
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Polyene antibiotics (i.e., amphotericin B and nystatin) have been incorporated into lipid-based delivery systems to decrease their toxicity and enhance their therapeutic index, the most common being liposomes. This chapter describes the protocols for preparing liposomal amphotericin B and determining the efficacy and toxicity of the formulations in ...
Agatha W K, Ng +2 more
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Biomimetic studies on polyenes
Org. Biomol. Chem., 2003The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions.
John E, Moses +4 more
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2016
Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
openaire +2 more sources