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Contribution of fungal diseases to the U.S. chronic disease burden. [PDF]
Clin Microbiol RevGhai RR +10 more
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Organic Letters, 2012
A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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2016
Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Synthesis of Aryl and Heterocyclic Polyenes and Their Activity in Free Radical Scavenging [PDF]
Journal of Chemical Research, 2018 Aryl polyenes and heterocyclic polyenes with the same central C20 unit of β,β-carotene but different terminal groups were synthesised. Their free radical scavenging activity was measured by a 1,1-diphenyl-2-picrylhydrazinyl spectrophotometric method ...
Kaiqun Wu +3 more
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Enantioselective polyene cyclizations
Organic & Biomolecular Chemistry, 2016A comprehensive review covering the field of enantioselective polyene cyclizations.
Chad N, Ungarean +2 more
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Quantum interference in polyenes
The Journal of Chemical Physics, 2014The explicit form of the zeroth Green's function in the Hückel model, approximated by the negative of the inverse of the Hückel matrix, has direct quantum interference consequences for molecular conductance. We derive a set of rules for transmission between two electrodes attached to a polyene, when the molecule is extended by an even number of carbons
Yuta Tsuji +3 more
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Biomimetic studies on polyenes
Org. Biomol. Chem., 2003The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions.
John E, Moses +4 more
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Biomimetic polyene cyclizations
Bioorganic Chemistry, 1976AbstractCertain polyenic substances having trans olefinic bonds in a 1,5 relationship can be induced to undergo stereospecific, non‐enzymic, cationic cyclization to give polycyclic products with all‐trans (“natural”) configuration. These transformations appear to mimic in principle the biogenetic conversion of squalene into polycyclic triterpenoids ...
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The Polyene Antifungal Antibiotics
1963During the early 1950’s there appeared reports, from time to time of the presence among the products elaborated by actinomycetes of antifungal antibiotics which exhibited very similar and very characteristic multipeaked ultraviolet absorption spectra. In 1954, with a good number of examples on record, these spectra were analyzed and identified as those
W, OROSHNIK, A D, MEBANE
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