Results 11 to 20 of about 16,341 (199)

EneA of Aspergillus fumigatus is a regulator of secondary metabolism and enhances nscA expression in presence of polyenes and Streptomyces [PDF]

Scientific Reports
Aspergillus fumigatus is a soil born fungus, which can induce severe aspergillosis in immunocompromised patients. In this study, we investigated the zinc cluster transcription factor EneA (enhancer of n scA expression A) of A.
Oskar Bunz, Jennifer Gerke, Oliver Bader, Emmanouil Bastakis, Merle Aden, Kai Heimel, Ralf Bürgers, Gerhard H. Braus, Christoph Sasse   +8 more
doaj   +2 more sources

Malassezia pachydermatis Acquires Resistance to Polyenes in the Laboratory Model [PDF]

Pathogens
This study presents a model investigation into the development of tolerance to polyene antifungal drugs (nystatin and natamycin) in strains of Malassezia pachydermatis.
Urszula Czyżewska, Sandra Chmielewska, Marek Bartoszewicz, Adam Tylicki   +3 more
doaj   +2 more sources

Antifungal Efficacy of Redox-Active Natamycin against Some Foodborne Fungi—Comparison with Aspergillus fumigatus

Foods, 2021
The fungal antioxidant system is one of the targets of the redox-active polyene antifungal drugs, including amphotericin B (AMB), nystatin (NYS), and natamycin (NAT).
Jong H. Kim, Christina C. Tam, Kathleen L. Chan, Luisa W. Cheng, Kirkwood M. Land, Mendel Friedman, Perng-Kuang Chang   +6 more
doaj   +1 more source

Recent Perspectives in the Management of Fungal Keratitis

Journal of Fungi, 2021
Mycotic keratitis is common in warm, humid regions with a varying profile of pathogenic fungi according to geographical origin, socioeconomic status, and climatic condition. Clinical diagnosis can be challenging in difficult cases and those refractory to
Nimmy Raj, Murugesan Vanathi, Nishat Hussain Ahmed, Noopur Gupta, Neiwete Lomi, Radhika Tandon   +5 more
doaj   +1 more source

Repurposing Antifungals for Host-Directed Antiviral Therapy?

Pharmaceuticals, 2022
Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that ...
Sebastian Schloer, Jonas Goretzko, Ursula Rescher   +2 more
doaj   +1 more source

Postantifungal Effect of Antifungal Drugs against Candida: What Do We Know and How Can We Apply This Knowledge in the Clinical Setting?

Journal of Fungi, 2022
The study of the pharmacological properties of an antifungal agent integrates the drug pharmacokinetics, the fungal growth inhibition, the fungicidal effect and the postantifungal activity, laying the basis to guide optimal dosing regimen selection.
Nerea Jauregizar, Guillermo Quindós, Sandra Gil-Alonso, Elena Suárez, Elena Sevillano, Elena Eraso   +5 more
doaj   +1 more source

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

Journal of Fungi, 2020
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image.
Hans Carolus, Siebe Pierson, Katrien Lagrou, Patrick Van Dijck   +3 more
doaj   +1 more source

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

Cells, 2023
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications.
Karolina M. Czajka, Krishnan Venkataraman, Danielle Brabant-Kirwan, Stacey A. Santi, Chris Verschoor, Vasu D. Appanna, Ravi Singh, Deborah P. Saunders, Sujeenthar Tharmalingam   +8 more
doaj   +1 more source

Candida parapsilosis Virulence and Antifungal Resistance Mechanisms: A Comprehensive Review of Key Determinants

Journal of Fungi, 2023
Candida parapsilosis is the second most common Candida species isolated in Asia, Southern Europe, and Latin America and is often involved in invasive infections that seriously impact human health. This pathogen is part of the psilosis complex, which also
Joana Branco, Isabel M. Miranda, Acácio G. Rodrigues   +2 more
doaj   +1 more source

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

Membranes, 2022
This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions.
Tammy Haro-Reyes, Lucero Díaz-Peralta, Arturo Galván-Hernández, Anahi Rodríguez-López, Lourdes Rodríguez-Fragoso, Iván Ortega-Blake   +5 more
doaj   +1 more source