Results 151 to 160 of about 91,656 (195)
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Useful Designs in the Synthesis of Trans-Fused Polyether Toxins
Chemical Reviews, 1995Eleuterio Álvarez, Ricardo Perez
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Model Studies Directed Towards Microalga Polyether Toxins
Bulletin des Sociétés Chimiques Belges, 1990AbstractIn view of the described results in acid‐induced polyepoxide cyclizations, the biosynthesis of fused polyether toxins may be better explained by a stepwise mechanism through oxonium ion intermediates acting on the enzyme‐bonded polyepoxide precursor.
Eleuterio Alvarez +4 more
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Geographical, Temporal, and Species Variation of the Polyether Toxins, Azaspiracids, in Shellfish
Environmental Science & Technology, 2003Azaspiracid Poisoning (AZP) is a new toxic syndrome that has caused human intoxications throughout Europe following the consumption of mussels (Mytilus edulis), harvested in Ireland. Shellfish intoxication is a consequence of toxin-bearing microalgae in the shellfish food chain, and these studies demonstrated a wide geographic distribution of toxic ...
Ambrose, Furey +5 more
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Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins.
Bulletin de la Societe de pathologie exotique (1990), 1992Experiments with novel nitrogenous coumarin-based reagents yielded moderately fluorescent derivatives of brevetoxin-3 and ciguatoxin-1. The diethylaminocoumarin-carbamic acid esters of brevetoxin-3 were resolved by high performance liquid chromatography into two derivative peaks that correspond to substitutions at the C-37 and C-41 hydroxyls.
Dickey, R. W. +3 more
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Brevetoxins: unique polyether dinoflagellate toxins
The FASEB Journal, 1989Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems.
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Studies on the biosynthesis of the polyether marine toxin dinophysistoxin-1 (DTX-1)
Tetrahedron Letters, 1994Abstract The biosynthetic origin of DTX-1 is establish on the basis of the NMR spectral data of samples obtained by addition of labelled [1- 13 C 1 ], [2- 13 C 1 ] and [1,2- 13 C 2 ] sodium acetate to artificial cultures of the dinoflagellate Prorocentrum lima.
Manuel Norte +2 more
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Polyether Toxins Implicated in Ciguatera and Seafood Poisoning
1990Naturally occurring polyether compounds are secondary metabolites presumably derived from polyketide biosynthetic pathways. Organisms of Streptomycetales were the first reported biogenetic origin of this class of compounds. Some of the compounds have been used as antibiotics for domestic animals.
Michio Murata, Takeshi Yasumoto
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ChemInform Abstract: Useful Designs in the Synthesis of trans‐Fused Polyether Toxins
ChemInform, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. ALVAREZ +4 more
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A unified stereochemical model for the polyepoxide cyclization route to marine polyether toxins
Tetrahedron Letters, 1991Abstract A stepwise intermediacy of oxocarbenium ions of type 2 provide strong support for the feasibility of the polyepoxide approach to ortho - and spiro -condensed polyether toxins of marine origin.
Eleuterio Alvarez +3 more
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Synthesis of a marine polyether toxin, okadaic acid (3) — synthesis of segment c
Tetrahedron, 1987Abstract The title compound was divided into three retrosynthetic segments, A, B and C, by disconnecting two C-C bonds at C- 14 15 and C- 27 28 . Synthesis of the segment C in the optically active natural form starting from a D-glucose derivatives is described.
Yoshiyasu Ichikawa +4 more
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