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Accelerated Clearance of Polyethylene Glycol-Modified Proteins by Anti-Polyethylene Glycol IgM
Bioconjugate Chemistry, 1999Tumor therapy by the preferential activation of a prodrug at tumor cells targeted with an antibody-enzyme conjugate may allow improved treatment efficacy with reduced side effects. We examined antibody-mediated clearance of poly(ethylene glycol)-modified beta-glucuronidase (betaG-sPEG) as a method to reduce serum concentrations of enzyme and minimize ...
Pin-Yi Wu +4 more
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Hypersensitivity to Polyethylene Glycols
The Journal of Clinical Pharmacology, 2013Tracy Prematta +3 more
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Fractionation of Plasma with Polyethylene Glycol
Vox Sanguinis, 1972C. Ruiz-Bravo, A. Polson
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Contact sensitivity to polyethylene glycols
Contact Dermatitis, 1990K. Singh +3 more
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[20] Protein precipitation with polyethylene glycol
1984Polyethylene glycol is a nondenaturing water-soluble polymer whose ability to precipitate protein from aqueous solution can be qualitatively understood in terms of an excluded volume mechanism. The increment in PEG concentration required to effect a given reduction in solubility is unique for a given protein-polymer pair, being insensitive to solution ...
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Zone fractionation of polyethylene glycols
1970Zone refining is based on the fact that the solubility of a solute in a liquid solution will be different than its solubility in a solid solution. The ratio of the solute concentration in the solid solution to its concentration in the liquid is defined as the distribution coefficient. Thus, 1) k « c s / Ci where k is the distribution coefficient and Cs
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Colonic lavage with polyethylene glycol
Medical Journal of Australia, 1985David R. Hunt +2 more
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[23] Precipitation of proteins with polyethylene glycol
1990Polyethylene glycol is a nondenaturing water-soluble polymer whose ability to precipitate protein from aqueous solution can be qualitatively understood in terms of an excluded volume mechanism. The increment in PEG concentration required to effect a given reduction in solubility is unique for a given protein-polymer pair, being insensitive to solution ...
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