Results 211 to 220 of about 815,697 (298)

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source

Detection of the Antithyroglobulin Antibody Precipitated with Polyethylene Glycol (PEG)

Folia Endocrinologica Japonica, 1977
MIYOSHI, Masanori, HIRAKAWA, Shuzo, HASEGAWA, Kan, MITSUNAGA, Mikio, TAKEHISA, Yoshiaki, SUZUKI, Shinya, OFUJI, Tadashi   +6 more
openaire   +2 more sources

False-positive troponin in a professional cyclist: a case report on avoiding misdiagnosis and unnecessary restrictions. [PDF]

Eur Heart J Case Rep
Popelier C, Koppens K, L'Hoyes W, Lambrecht A, Van Puyvelde T.   +4 more
europepmc   +1 more source

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

Self-Standing Cutin Isolate Films. [PDF]

Polymers (Basel)
Hromiš N, Bučko S, Stojanović Z, Popović S, Pajin B, Stožinić M, Zhang D, Omerović N, Katona J.   +8 more
europepmc   +1 more source

Mitochondria‐Directed Redox Phospholipid Polymers for Cancer Therapy

Cancer Science, EarlyView.
A mitochondria‐directed redox polymer containing an antioxidant‐oxidizing ferrocene unit and a triphenylphosphonium unit is prepared by a simple copolymerization strategy for cancer treatment. Incorporation of an appropriate amount of the directed unit enhances anticancer activity, elevates intracellular ROS levels, induces apoptosis, and suppresses in 
Yuma Kato, Yuki Ogawa, Akira Ito, Masahiro Kaneko   +3 more
wiley   +1 more source

Occurrence of Human Norovirus and Hepatitis A Virus in Domestic Agricultural Waters. [PDF]

Food Saf (Tokyo)
Yu C, Yang Q, Kulka M, Lipp E, Kauffman M.   +4 more
europepmc   +1 more source

Influence of rubbing during etching on surface roughness and interfacial characteristics of intact enamel

European Journal of Oral Sciences, EarlyView.
Abstract Rubbing phosphoric acid during etching has been shown to improve surface roughness in prepared enamel. This study aimed to compare intact enamel's surface roughness and resin tag lengths after etching with and without rubbing. Extracted sound third molars were used for testing, mesially for conventional and distally for dynamic (rubbing ...
Moana Biedermann, Iosif Sifakakis, Spiros Zinelis, George Eliades, Theodore Eliades, Raphael Patcas   +5 more
wiley   +1 more source

Stepwise PEG Precipitation Coupled with Hydrophobic Interaction Chromatography Enables the Production of Highly Specific Anti-Ag85B IgY for Tuberculosis Immunodiagnostics. [PDF]

Infect Drug Resist
Kusmiati M, Gaffar S, Kusuma SAF.
europepmc   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source