Results 71 to 80 of about 1,875 (207)

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

open access: yesChemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly   +7 more
wiley   +1 more source

Polyfunctionality and inflectional economy

open access: yesLinguistic Issues in Language Technology, 2014
This paper serves two purposes. It is a summary of much work concerning One compelling kind of evidence for the autonomy of a language’s morphology is the incidence of inflectional polyfunctionality, the systematic use of the same morphology to express distinct but related morphosyntactic content.
openaire   +2 more sources

Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley   +1 more source

Convenient Synthesis of Polyfunctionalized β-Fluoropyrroles from Rhodium(II)-Catalyzed Intramolecular N−H Insertion Reactions

open access: yes, 2016
Polyfunctionalized β-fluoropyrrole can be readily prepared from rhodium(II) acetate-catalyzed intramolecular N−H insertion reaction of δ-amino-γ,γ-difluoro-α-diazo-β-ketoesters.
Shizheng Zhu (1963603)   +1 more
core   +1 more source

Anti-Inflammatory Properties of Dendrimers per se

open access: yesThe Scientific World Journal, 2011
Dendrimers are polybranched and polyfunctionalized tree-like polymers. Unlike linear polymers, they have perfectly defined structure and molecular weight, due to their iterative step-by-step synthesis.
Myriam Hayder   +4 more
doaj   +1 more source

MW-Assisted Synthesis of Eight New 6-Nitrilmethyl Pyrrolo[3,4-b]pyridin-5-Ones via a Domino Process: aza Diels–Alder/N-Acylation/Aromatization

open access: yesProceedings, 2019
An efficient Microwave (MW)-assisted synthesis of eight new 6-nitrilmethyl-pyrrolo[3,4-b]pyridin-5-ones via a domino process: aza Diels–Alder/N-acylation/aromatization (dehydration–decarboxylation) from their corresponding 2-aminonitrile ...
Manuel A. Rentería-Gómez   +4 more
doaj   +1 more source

Three-Bond Breaking of Cyclic Anhydrides: Easy Access to Polyfunctionalized Naphthalenes and Phenanthrenes

open access: yes, 2016
Benzannulation of phthalic anhydrides with alkynes to polyfunctionalized naphthalenes and phenanthrenes was confirmed to be straightforward using a palladium catalytic system.
Sorour Nouraldinmousa (1930423)   +2 more
core   +1 more source

Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis

open access: yesAngewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Hidden but Powerful: Thiophenes and their saturated analogues have been demonstrated to be versatile C4‐building blocks that can be rapidly applied to natural product synthesis and the construction of functionalized (hetero)arenes. This minireview aims to provide a concise overview of the strategies and implementations of these sulfur‐containing ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

Diastereoselective One-Pot Synthesis of Polyfunctionalized Bicyclo[3.3.1]nonanes by an Anionic Domino Process.

open access: yes, 2009
One pot, many reactions! The reaction of two equivalents of ethyl(2-bromomethyl)acrylate with dinitroalkanes (see scheme) leads to the one-pot, diastereoselective synthesis of a variety of polyfunctionalized bicyclo[3.3.1]nonanes in very good overall ...
BARBONI, Luciano   +14 more
core   +1 more source

A Post-Synthetic Modification Approach to Expand MIL-101-NH2 Functionalization

open access: yesChemistry
Considering the importance of organic functionalization of MOFs, we here report a simple, tunable and efficient one-step post-modification procedure for introducing amino and carboxylic groups into the mesoporous metal–organic framework Al- and Cr-MIL ...
Alain Vigroux   +5 more
doaj   +1 more source

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