Results 1 to 10 of about 885 (143)

Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates [PDF]

Molecules
In this study, the synthesis of a series of alkaloid analogs—isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method.
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Zharkyn Zh. Zhumagaliyeva, Gulzhaukhar A. Toktarbay, Irina A. Kolesnik, Ekaterina A. Akishina, Evgenij A. Dikusar, Vladimir I. Potkin, Aliaksandr L. Pushkarchuk, Tatiana I. Terpinskaya, Fedor I. Zubkov, Mikhail S. Grigoriev, Hongwei Zhou   +12 more
doaj   +2 more sources

Studies on the Complexation of Platinum(II) by Some 4-Nitroisothiazoles and the Cytotoxic Activity of the Resulting Complexes [PDF]

Molecules
Five novel platinum(II) complexes C1–C5 were synthesized in the reaction of the appropriate substituted 4-nitroisothiazoles with K2PtCl4 and characterized with elemental analysis, ESI MS spectrometry, NMR spectroscopy, and IR spectroscopy.
Andrzej Regiec, Joanna Wietrzyk, Magdalena Milczarek, Andrzej Kochel, Henryk Mastalarz   +4 more
doaj   +2 more sources

ANN-QSAR, Molecular Docking, ADMET Predictions, and Molecular Dynamics Studies of Isothiazole Derivatives to Design New and Selective Inhibitors of HCV Polymerase NS5B [PDF]

Pharmaceuticals
Background/Objectives: RNA polymerase (NS5B), serves as a crucial target for pharmaceutical interventions aimed at combating the hepatitis C virus (HCV), which poses significant health challenges worldwide.
Maroua Fattouche, Salah Belaidi, Oussama Abchir, Walid Al-Shaar, Khaled Younes, Muneerah Mogren Al-Mogren, Samir Chtita, Fatima Soualmia, Majdi Hochlaf   +8 more
doaj   +2 more sources

Isothiazole Derivatives as Antiviral Agents

Antiviral Chemistry and Chemotherapy, 2007
We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-phenylisothiazol-3-yl) disulphanyl-4-isothiazole-carbonitrile and S-(4-cyano-5-phenylisothiazol-3-yl)- O-ethyl thiocarbonate, which were found to be effective against both HIV-1 (IIIB) and HIV-2 (ROD).
Adriana Garozzo, Christophe Pannecouque, Erik de Clercq   +2 more
exaly   +5 more sources

Adults of Sun Coral Tubastraea coccinea (Lesson 1829) Are Resistant to New Antifouling Biocides [PDF]

Toxics
Biocides used in antifouling (AF) paints, such as 4,5-dichlorine-2-n-octyl-4-isothiazole-3-one (DCOIT), can gradually leach into the environment. Some AF compounds can persist in the marine environment and cause harmful effects to non-target organisms ...
Isabela Martins, Kátia Cristina Cruz Capel, Denis Moledo de Souza Abessa   +2 more
doaj   +2 more sources

Synthesis of Novel Vanillin Derivatives Containing Isothiazole Moieties and its Synergistic Effect in Mixtures with Insecticides

Natural Product Communications, 2009
Reaction between 4-formyl-2-methoxyphenyl 4,5-dichloroisothiazole-3-carboxylate with various aromatic amines led to azomethins 2-7 formation. By treatment of azomethins 2-7 with sodium triacetoxyborohydride corresponding amines 8-11 were obtained. During
Vladimir Potkin
exaly   +2 more sources

Design and Synthesis of Pyrimidine Amine Containing Isothiazole Coumarins for Fungal Control [PDF]

ACS Omega, 2023
Kun Li, Mengyuan Li, Haolin Zhong, Liangfu Tang, You Lv, Zhijin Fan   +5 more
doaj   +2 more sources

One-Pot Silylation–Amination Synthesis of 3‑N‑Substituted Benzo[d]isothiazole 1,1-Dioxides [PDF]

ACS Omega
Guilherme Arraché Gonçalves, Lídia Klatt Oliveira, Mauro Neves Muniz, Júlia Oliveira Santos, Sidnei Moura, Rafael Stieler, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado   +8 more
doaj   +2 more sources

Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride with 2-(Phenylsulfonyl)acetonitrile

Molbank, 2022
The reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-(phenylsulfonyl)acetonitrile (1 equiv) in the presence of pyridine (2 equiv) gave S-(3-chloro-5-cyanoisothiazol-4-yl)benzenesulfonothioate and (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-2-
Konstantinos Plakas, Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +3 more
doaj   +1 more source

Methyl 3-Bromo-5-carbamoylisothiazole-4-carboxylate

Molbank, 2023
Reaction of methyl 3-bromo-5-cyanoisothiazole-4-carboxylate with conc. H2SO4 gave methyl 3-bromo-5-carbamoylisothiazole-4-carboxylate in 93% yield. The compound was fully characterized.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source