Results 1 to 10 of about 871 (158)

Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates [PDF]

Molecules
In this study, the synthesis of a series of alkaloid analogs—isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method.
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Zharkyn Zh. Zhumagaliyeva, Gulzhaukhar A. Toktarbay, Irina A. Kolesnik, Ekaterina A. Akishina, Evgenij A. Dikusar, Vladimir I. Potkin, Aliaksandr L. Pushkarchuk, Tatiana I. Terpinskaya, Fedor I. Zubkov, Mikhail S. Grigoriev, Hongwei Zhou   +12 more
doaj   +2 more sources

Studies on the Complexation of Platinum(II) by Some 4-Nitroisothiazoles and the Cytotoxic Activity of the Resulting Complexes [PDF]

Molecules
Five novel platinum(II) complexes C1–C5 were synthesized in the reaction of the appropriate substituted 4-nitroisothiazoles with K2PtCl4 and characterized with elemental analysis, ESI MS spectrometry, NMR spectroscopy, and IR spectroscopy.
Andrzej Regiec, Joanna Wietrzyk, Magdalena Milczarek, Andrzej Kochel, Henryk Mastalarz   +4 more
doaj   +2 more sources

On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate [PDF]

Molecules, 2021
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal are ...
Joana F. Leal, Bruno Guerreiro, Patrícia S. M. Amado, André L. Fernandes, Luísa Barreira, José A. Paixão, Maria L. S. Cristiano   +6 more
doaj   +2 more sources

ANN-QSAR, Molecular Docking, ADMET Predictions, and Molecular Dynamics Studies of Isothiazole Derivatives to Design New and Selective Inhibitors of HCV Polymerase NS5B [PDF]

Pharmaceuticals
Background/Objectives: RNA polymerase (NS5B), serves as a crucial target for pharmaceutical interventions aimed at combating the hepatitis C virus (HCV), which poses significant health challenges worldwide.
Maroua Fattouche, Salah Belaidi, Oussama Abchir, Walid Al-Shaar, Khaled Younes, Muneerah Mogren Al-Mogren, Samir Chtita, Fatima Soualmia, Majdi Hochlaf   +8 more
doaj   +2 more sources

Isothiazole Derivatives as Antiviral Agents

Antiviral Chemistry and Chemotherapy, 2007
We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-phenylisothiazol-3-yl) disulphanyl-4-isothiazole-carbonitrile and S-(4-cyano-5-phenylisothiazol-3-yl)- O-ethyl thiocarbonate, which were found to be effective against both HIV-1 (IIIB) and HIV-2 (ROD).
Adriana Garozzo, Christophe Pannecouque, Francesco Guerrera   +2 more
exaly   +5 more sources

Adults of Sun Coral Tubastraea coccinea (Lesson 1829) Are Resistant to New Antifouling Biocides [PDF]

Toxics
Biocides used in antifouling (AF) paints, such as 4,5-dichlorine-2-n-octyl-4-isothiazole-3-one (DCOIT), can gradually leach into the environment. Some AF compounds can persist in the marine environment and cause harmful effects to non-target organisms ...
Isabela Martins, Kátia Cristina Cruz Capel, Denis Moledo de Souza Abessa   +2 more
doaj   +2 more sources

Design and Synthesis of Pyrimidine Amine Containing Isothiazole Coumarins for Fungal Control [PDF]

ACS Omega, 2023
Kun Li, Mengyuan Li, Haolin Zhong, Liangfu Tang, You Lv, Zhijin Fan   +5 more
doaj   +2 more sources

Aminoisothiazolamides, a new class of potent inhibitors of lysyl-tRNA synthetase. [PDF]

Pest Manag Sci
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
Bernier D, Barber DM, Bojack G, Bollenbach-Wahl B, Churchman L, Döller U, Fahrenhorst-Jones T, Freigang J, Gatzweiler E, Hartfiel C, Hilmi C, Huet Y, Laber B, Lange G, Lee S, Lempereur V, Mosrin M, Müller T, Payne CM, Peters O, Posa L, Rees S, Reingruber AM, Rey J, Tiebes J, Tilmant K, Frackenpohl J.   +26 more
europepmc   +2 more sources

The synthesis and application of 3-arylazo-4-phenylthieno[2,3-c]isothiazole and ethyl 3-arylazo-4-phenylthieno[2,3-c]isothiazole-5-carboxylate [PDF]

Journal of the Serbian Chemical Society, 2005
The paper describes the synthesis of 3-amino-4-phenylthieno[2,3-c]isothiazole and ethyl 3-amino-4-phenylthieno[2,3-c]isothiazole-5-carboxylate and their utilization to prepare a range of azo disperse dyes.
G. G. PAWAR, P. BINEESH, P. S. R. KUMAR, D.W. RANGNEKAR, V. R. KANETKAR   +4 more
doaj   +3 more sources

Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride with 2-(Phenylsulfonyl)acetonitrile

Molbank, 2022
The reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-(phenylsulfonyl)acetonitrile (1 equiv) in the presence of pyridine (2 equiv) gave S-(3-chloro-5-cyanoisothiazol-4-yl)benzenesulfonothioate and (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-2-
Konstantinos Plakas, Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +3 more
doaj   +1 more source