Results 31 to 40 of about 1,392 (198)

Isothiazoles. Part II. Reaction of d-diethylamino-4-(4-methoxyphenyl)-isothiazole-1,1-dioxide with sodium azide.

, 1993
3-Diethylamino-4-(4-methoxyphenyl)-isothiazole-1,1-dioxide 1, was reacted with azide ion in different solvents. Depending on reaction conditions 4-diethylamino-3a,6a-dihydro-3a-(4-methoxyphenyl)-1H-isothiazole-[4,5 -d]-1,2,3-triazole-6,6-dioxide 3 and/or
O. Carugo, F. Clerici, D. Pocar, Donato Pocarb, Oliviero Carugo, Francesca Clerici   +5 more
core   +1 more source

Overview of Photochemical Reactions for the Synthesis of Aza and Oxa‐Spirocyclic Compounds Under Visible Light Irradiation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review presents the visible‐light‐mediated photochemical reaction for the synthesis of aza, oxa, and aza–oxa spirocyclic compounds via photoinduced electron transfer (PET), hydrogen atom transfer (HAT), single‐electron transfer (SET), or energy transfer (EnT) pathways.
Annu Bhardwaj, Shivangi Jaiswal, Khushboo Bhardwaj, Swapnil Sharma, Jaya Dwivedi   +4 more
wiley   +1 more source

Isothiazoles. Part VII. An efficient palladinm-catalyzed functionalization of 3-amino-4-aryl-isothiazole 1,1-dioxides with organostannanes

, 1997
The palladium-catalyzed reaction of 5-bromo-3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (3) with a variety of vinyl-, aryl-, heteroaryl- and alkynylstannanes 4 provides a general and efficient method for the synthesis of 5-substituted ...
E. Erba, M.L. Gelmi, M. Valle, F. Clerici   +3 more
core   +1 more source

Thienoisothiazoles. II. The synthesis of 5-alkylthioisothiazoles and the preparation of Thieno[3,2-d]isothiazole derivatives

, 1982
Alkylation of the reaction product of sodium 3-iminobutyronitrile and carbon disulfide produces alkyl 2-cyano-3-iminodithiobutyrates (1) in moderate yield, which on iodine oxidation afford 5-alkylthio-3-methylisothiazole-4-carbonitriles (2b-e).
HD Krebs, FC James
core   +1 more source

5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile)

Molbank
The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with bromine (2 equiv.) in CCl4 gave 3,5-dibromoisothiazole-3-carbonitrile and 5,5′-thiobis(3-bromoisothiazole-4-carbonitrile) in 7% and 18% yields, respectively.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Light‐Driven [2 + 2] Cycloaddition Strategies for the Synthesis of Cyclobuta[b]indoles and Their Derivatives

ChemPhotoChem, Volume 10, Issue 6, June 2026.
This review surveys the literature on light‐driven dearomative [2+2] cycloadditions of indoles, highlighting their power to access complex cyclobuta[b]indole frameworks. Advances in photocatalysis, sensitizer design, and reaction engineering enable selective and sustainable assembly of strained three‐dimensional architectures, expanding opportunities ...
Maria Chiara Cabua, Davide Moi, Alberto Luridiana, Francesco Secci, Emanuele Cocco   +4 more
wiley   +1 more source

A mild and efficient synthesis of 3-Aminosubstituted Isothiazole S-Oxides and their 5-Sulfanylsubstituted derivatives

, 2008
The present paper describes a mild and efficient method to synthesize 3-aminosubstituted isothiazole sulfoxides taking advantage of arylsulfonyloxaziridines.
A. Casoni, A. Contini, A. Sala, F. Clerici, S. Pellegrino   +4 more
core   +1 more source

Mannich Reaction With Pyridoxal 5′‐Phosphate Dependent Decarboxylative Aldolase for Synthesis of Noncanonical α‐Amino Acids

ChemistryEurope, Volume 4, Issue 1, January 2026.
The pyridoxal 5′‐phosphate dependent decarboxylative aldolase, UstD was engineered to catalyze a Mannich reaction with cyclic imines. This enzymatic route was applied to synthesize 23 enantioenriched noncanonical amino acids with benzosultam side chains, achieving yields up to 96%, a total turnover number (TTN) of 7500, and excellent stereoselectivity (
Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao   +4 more
wiley   +1 more source

Thieno[3,2‐b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode

Angewandte Chemie, Volume 137, Issue 1, January 2, 2025.
Weak interaction of thieno[3,2‐b]pyridine with the kinase hinge region allows for design of highly selective inhibitors of underexplored kinases with variable binding modes. The newly identified chemical biology probe MU1920 targets the kinase Haspin with exquisite kinome‐wide selectivity.
Paula Martín Moyano, Tadeáš Kubina, Štěpán Owen Paruch, Aneta Jarošková, Jan Novotný, Veronika Skočková, Petra Ovesná, Tereza Suchánková, Polina Prokofeva, Bernhard Kuster, Michal Šmída, Apirat Chaikuad, Andreas Krämer, Stefan Knapp, Karel Souček, Kamil Paruch   +15 more
wiley   +2 more sources

Intramolecular Carbene C-H Insertion Reactions of 2-Diazo-2-sulfamoylacetamides

Molecules, 2019
The intramolecular C-H insertions of carbenes derived from 2-diazo-2-sulfamoylacetamides were studied. 2-Diazo-2-sulfamoylacetamides were first prepared from chloroacetyl chloride and secondary amines through acylation followed by sequential treatments ...
Chuqiang Que, Peipei Huang, Zhanhui Yang, Ning Chen, Jiaxi Xu   +4 more
doaj   +1 more source