Results 31 to 40 of about 1,345 (190)

A mild and efficient synthesis of 3-Aminosubstituted Isothiazole S-Oxides and their 5-Sulfanylsubstituted derivatives

, 2008
The present paper describes a mild and efficient method to synthesize 3-aminosubstituted isothiazole sulfoxides taking advantage of arylsulfonyloxaziridines.
A. Casoni, A. Contini, A. Sala, F. Clerici, S. Pellegrino   +4 more
core   +1 more source

Isothiazoles. Part V. Cycloaddition reaction of nitrile oxides to 3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide: An entry to 5-acyl- and 5-cyano-isothiazole 1,1-dioxide derivatives

, 1995
Nitrile oxides 2 reacted with 3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) affording through a highly regioselective 1,3-dipolar cycloaddition reaction isothiazolo[5,4-d]isoxazoline 4,4-dioxides 3.
M.L. Gelmi, F. Clerici, F. Ferraris
core   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Microwave Spectroscopy Of Isothiazole [PDF]

, 2022
Recently, cyclic molecules such as benzonitrile \footnote{B.A. McGuire, A.M. Burkhardt, S. Kalenskii, C.N. Shingledecker, A.J. Remijan, E. Herbst, M.C.
Kobayashi, Kaori
core   +1 more source

Overview of Photochemical Reactions for the Synthesis of Aza and Oxa‐Spirocyclic Compounds Under Visible Light Irradiation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review presents the visible‐light‐mediated photochemical reaction for the synthesis of aza, oxa, and aza–oxa spirocyclic compounds via photoinduced electron transfer (PET), hydrogen atom transfer (HAT), single‐electron transfer (SET), or energy transfer (EnT) pathways.
Annu Bhardwaj, Shivangi Jaiswal, Khushboo Bhardwaj, Swapnil Sharma, Jaya Dwivedi   +4 more
wiley   +1 more source

Light‐Driven [2 + 2] Cycloaddition Strategies for the Synthesis of Cyclobuta[b]indoles and Their Derivatives

ChemPhotoChem, Volume 10, Issue 6, June 2026.
This review surveys the literature on light‐driven dearomative [2+2] cycloadditions of indoles, highlighting their power to access complex cyclobuta[b]indole frameworks. Advances in photocatalysis, sensitizer design, and reaction engineering enable selective and sustainable assembly of strained three‐dimensional architectures, expanding opportunities ...
Maria Chiara Cabua, Davide Moi, Alberto Luridiana, Francesco Secci, Emanuele Cocco   +4 more
wiley   +1 more source

Isothiazolo[5,4-d]isoxazole S,S-dioxides and pyrazolo [3,4-d]-isothiazole S,S-dioxides through cycloaddition reaction on 3-benzylaminoisothiazole S,S-dioxides

, 2006
By reacting 4,5-unsubstituted isothiazole dioxides with diazoalkanes and nitrile oxides bicyclic pyrazolo[3,4-d]isothiazole and isothiazolo[5,4-d]isoxazole S,S-dioxides were obtained in good yield through a regioselective cycloaddn. reaction.
M.L. Gelmi, C. Monzani, A. Sala, F. Clerici, D. Pocar   +4 more
core   +1 more source

Mannich Reaction With Pyridoxal 5′‐Phosphate Dependent Decarboxylative Aldolase for Synthesis of Noncanonical α‐Amino Acids

ChemistryEurope, Volume 4, Issue 1, January 2026.
The pyridoxal 5′‐phosphate dependent decarboxylative aldolase, UstD was engineered to catalyze a Mannich reaction with cyclic imines. This enzymatic route was applied to synthesize 23 enantioenriched noncanonical amino acids with benzosultam side chains, achieving yields up to 96%, a total turnover number (TTN) of 7500, and excellent stereoselectivity (
Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao   +4 more
wiley   +1 more source

The terapeutic potential of isothiazole derivatives : the effect of compound structure on activity [PDF]

, 2018
Isothiazole derivatives are compounds with potentially interesting biological activity. The work on the isothiazole ring was successfully conducted by Machoń from the Department of Organic Chemistry at Wrocław Medical University.
Mączyński, M., Jęśkowiak, I., Ryng, S.   +2 more
core  

Isothiazoles. Part II. Reaction of d-diethylamino-4-(4-methoxyphenyl)-isothiazole-1,1-dioxide with sodium azide.

, 1993
3-Diethylamino-4-(4-methoxyphenyl)-isothiazole-1,1-dioxide 1, was reacted with azide ion in different solvents. Depending on reaction conditions 4-diethylamino-3a,6a-dihydro-3a-(4-methoxyphenyl)-1H-isothiazole-[4,5 -d]-1,2,3-triazole-6,6-dioxide 3 and/or
O. Carugo, F. Clerici, D. Pocar
core   +1 more source