Results 11 to 20 of about 1,345 (190)

The synthesis and application of 3-arylazo-4-phenylthieno[2,3-c]isothiazole and ethyl 3-arylazo-4-phenylthieno[2,3-c]isothiazole-5-carboxylate [PDF]

Journal of the Serbian Chemical Society, 2005
The paper describes the synthesis of 3-amino-4-phenylthieno[2,3-c]isothiazole and ethyl 3-amino-4-phenylthieno[2,3-c]isothiazole-5-carboxylate and their utilization to prepare a range of azo disperse dyes.
G. G. PAWAR, P. BINEESH, P. S. R. KUMAR, D.W. RANGNEKAR, V. R. KANETKAR   +4 more
doaj   +4 more sources

Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation. [PDF]

ChemMedChem
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Rocca E, Bedini A, Scalvini L, Galvani F, Castelli R, Sarcone L, Recchia A, Fanini F, Tran A, Rivara S, Spadoni G, Piomelli D, Mor M.   +12 more
europepmc   +2 more sources

Aminoisothiazolamides, a new class of potent inhibitors of lysyl-tRNA synthetase. [PDF]

Pest Manag Sci
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
Bernier D, Barber DM, Bojack G, Bollenbach-Wahl B, Churchman L, Döller U, Fahrenhorst-Jones T, Freigang J, Gatzweiler E, Hartfiel C, Hilmi C, Huet Y, Laber B, Lange G, Lee S, Lempereur V, Mosrin M, Müller T, Payne CM, Peters O, Posa L, Rees S, Reingruber AM, Rey J, Tiebes J, Tilmant K, Frackenpohl J.   +26 more
europepmc   +2 more sources

3-Chloro-4-(p-tolyl)isothiazole-5-carbonitrile

Molbank, 2023
A reaction of 3-chloroisothiazole-5-carbonitrile with 1-iodo-4-methylbenzene (2 equiv.) produced 3-chloro-4-(p-tolyl)isothiazole-5-carbonitrile in a 60% yield. The compound was fully characterized.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Synthesis of 3-Bromo-4-phenylisothiazole-5-carboxylic Acid and 3-Bromoisothiazole-5-carboxylic Acid

Molbank, 2023
Reactions of 3-bromo-4-phenylisothiazole-5-carboxamide and 3-bromoisothiazole-5-carboxamide with NaNO2 (4 equiv.), in TFA, at ca. 0 °C gave the carboxylic acid products in 99% and 95% yields, respectively. The two compounds were fully characterized.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments

Molecules, 2022
An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed.
Gulim K. Mukusheva, Aigerym R. Zhasymbekova, Roza B. Seidakhmetova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Sergey K. Petkevich, Evgenij A. Dikusar, Vladimir I. Potkin   +7 more
doaj   +1 more source

Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

Molecules, 2022
A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity.
Gulim K. Mukusheva, Aigerym R. Zhasymbekova, Zharkyn Zh. Zhumagalieva, Roza B. Seidakhmetova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Sergey K. Petkevich, Evgenij A. Dikusar, Vladimir I. Potkin   +8 more
doaj   +1 more source

Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles

Molecules, 2020
The importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic ...
Vânia Silva, Cátia Silva, Pedro Soares, E. Manuela Garrido, Fernanda Borges, Jorge Garrido   +5 more
doaj   +1 more source

The synthesis of several members of the new imidazo(4,5-d)isothiazole ring system: Novel 5:5 fused analogs of purines and purine nucleosides.

, 1994
The chemistry of purines, purine nucleosides, and their derivatives has been extensively studied, and many analogs of this important class of compounds exert a significant biological effect.
Swayze, Eric Edward
core   +7 more sources

On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate

Molecules, 2021
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal are ...
Joana F. Leal, Bruno Guerreiro, Patrícia S. M. Amado, André L. Fernandes, Luísa Barreira, José A. Paixão, Maria L. S. Cristiano   +6 more
doaj   +1 more source