Results 41 to 50 of about 1,345 (190)

Thieno[3,2‐b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode

Angewandte Chemie, Volume 137, Issue 1, January 2, 2025.
Weak interaction of thieno[3,2‐b]pyridine with the kinase hinge region allows for design of highly selective inhibitors of underexplored kinases with variable binding modes. The newly identified chemical biology probe MU1920 targets the kinase Haspin with exquisite kinome‐wide selectivity.
Paula Martín Moyano, Tadeáš Kubina, Štěpán Owen Paruch, Aneta Jarošková, Jan Novotný, Veronika Skočková, Petra Ovesná, Tereza Suchánková, Polina Prokofeva, Bernhard Kuster, Michal Šmída, Apirat Chaikuad, Andreas Krämer, Stefan Knapp, Karel Souček, Kamil Paruch   +15 more
wiley   +2 more sources

5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile)

Molbank
The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with bromine (2 equiv.) in CCl4 gave 3,5-dibromoisothiazole-3-carbonitrile and 5,5′-thiobis(3-bromoisothiazole-4-carbonitrile) in 7% and 18% yields, respectively.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Intramolecular Carbene C-H Insertion Reactions of 2-Diazo-2-sulfamoylacetamides

Molecules, 2019
The intramolecular C-H insertions of carbenes derived from 2-diazo-2-sulfamoylacetamides were studied. 2-Diazo-2-sulfamoylacetamides were first prepared from chloroacetyl chloride and secondary amines through acylation followed by sequential treatments ...
Chuqiang Que, Peipei Huang, Zhanhui Yang, Ning Chen, Jiaxi Xu   +4 more
doaj   +1 more source

A Review on Vehicle Tire Elastomers and Tire Wear Particles: Composition, Degradation Mechanisms, Analytical Methods, and Predictive Multiscale Computational Modeling

Advances in Polymer Technology, Volume 2026, Issue 1, 2026.
The study of the properties, chemical composition, and degradation patterns of rubber materials used in vehicle tires remains a complex and interdisciplinary task. Rubber for tires—more precisely, complex mixtures of elastomers containing fillers, plasticizers, binders, and other additives—is a condensed chemically active material, the composition and ...
Roman Tangalychev, Vasilii Korotenko, Valentin Ivanov, Srijoni Sengupta   +3 more
wiley   +1 more source

Thienoisothiazoles. II. The synthesis of 5-alkylthioisothiazoles and the preparation of Thieno[3,2-d]isothiazole derivatives

, 1982
Alkylation of the reaction product of sodium 3-iminobutyronitrile and carbon disulfide produces alkyl 2-cyano-3-iminodithiobutyrates (1) in moderate yield, which on iodine oxidation afford 5-alkylthio-3-methylisothiazole-4-carbonitriles (2b-e).
HD Krebs, FC James
core   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Isothiazoles. Part VII. An efficient palladinm-catalyzed functionalization of 3-amino-4-aryl-isothiazole 1,1-dioxides with organostannanes

, 1997
The palladium-catalyzed reaction of 5-bromo-3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (3) with a variety of vinyl-, aryl-, heteroaryl- and alkynylstannanes 4 provides a general and efficient method for the synthesis of 5-substituted ...
E. Erba, M.L. Gelmi, M. Valle, F. Clerici   +3 more
core   +1 more source

Carbon and Heteroatom Activation via N‐Heterocyclic Carbene‐Bound Dearomative Intermediates for Stereoselective Annulation Reactions

Chemistry – A European Journal, Volume 31, Issue 66, November 25, 2025.
Use of N‐heterocyclic carbenes (NHCs) to activate carbon and heteroatoms in aromatic compounds is reviewed based on key dearomative NHC‐bound intermediates, i.e., ortho‐quinodimethanes (o‐QDMs), ortho‐quinone methides (o‐QMs) and aza‐analogs (aza‐o‐QMs), aza‐fulvene and triaza‐diene intermediates.
Carmela De Risi, Graziano Di Carmine, Daniele Ragno, Lorenzo Poletti, Alessandro Massi   +4 more
wiley   +1 more source

Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation

, 2005
Isothiazole dioxides have been shown to inhibit Trypanosoma brucei protein farnesyltransferase (PFTase) in isolated enzyme, but elicited only a minor effect on mammalian PFTase.
FERRI, NICOLA, N. Ferri, F. Clerici, K. Yokoyama, D. Pocar, A. Corsini   +5 more
core   +1 more source

Photochemische Permutation von Indazolen zu Benzimidazolen

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Hier stellen wir eine photochemische Strategie für die direkte Permutation von 1H‐ und 2H‐Indazolen zu Benzimidazolen vor. Dieser Ansatz beruht auf einem zweistufigen Mechanismus aus Tautomerisierung im angeregten Zustand und photochemischer Umlagerung, bietet einen breiten Anwendungsbereich, hohe Ausbeuten und funktionelle Gruppentoleranz und erhöht ...
Thiago dos Santos, Cornelia S. Buettner, Dilara Berna Yildiz, Martina Mamone, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source