Results 41 to 50 of about 871 (158)

2-((3R,9bS)-5,5-Dioxido-2,3-dihydro-9bH-benzo[4,5]isothiazolo[3,2-b]oxazol-3-yl)-1-phenylethan-1-one

Molbank
A highly efficient method has been developed for preparing 2-((3R,9bS)-5,5-dioxido-2,3-dihydro-9bH-benzo[4,5]isothiazolo[3,2-b]oxazol-3-yl)-1-phenylethan-1-one.
Yeongju Kim, Sung-Gon Kim
doaj   +1 more source

Discovery of novel benzosultam CRBN ligands

Bulletin of the Korean Chemical Society, Volume 46, Issue 1, Page 48-56, January 2025.
Five novel benzosultam CRBN ligands were synthesized and evaluated their CRBN binding affinities. The 5‐amino benzosultam ligand (5b) demonstrated a CRBN binding affinity over 20 times stronger than lenalidomide. Molecular docking studies suggest the enhanced binding affinities could be from an additional hydrogen bond of benzosultams with Trp400 of ...
Hoyeong Park, Santosh Shivanand Raikar, Yonghyo Kim, Chong Hak Chae, Yong‐Hee Cho, Pilho Kim   +5 more
wiley   +1 more source

One-Step Synthesis of 2-Alkenecarbodithioate Esters from Substituted Propargyl Ethers, and Their Conversion into Isothiazole Ring through a [4+1] Type Oxidative Ring Closure

Natural Product Communications, 2017
Treatment of substituted propargyl methyl ethers with a base and elemental sulfur in the presence of a thiolate ion afforded 2-alkenecarbodithioate esters in good yields.
Kazuaki Shimada, Fumiya Ishikawa, Md. Ashraful Alam, Toshinobu Korenaga   +3 more
doaj   +1 more source

Pentathiepins are an understudied molecular prism of biological activities

Archiv der Pharmazie, Volume 357, Issue 12, December 2024.
Pentathiepins are cyclic sulfur‐rich compounds that possess remarkable chemical stability, unique structural features, and an extraordinary variety of biological activities. Nonetheless, they have only drawn the attention of the scientific community on a few occasions, generally after the serendipitous discovery of some of their properties. This review
Luca Pozzetti, Christopher R. M. Asquith
wiley   +1 more source

Relevance and Potential Applications of C2‐Carboxylated 1,3‐Azoles

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
Edoxaban and 2‐acetylthiazole were identified as relevant C2‐carboxylated 1,3‐azoles within the chemical space of approved drug and cosmetics. The potential of the C2‐carboxylated 1,3‐azole substructure motif was supported by target prediction as well as an analysis of bioisosteres.
Kerrin Janssen, Johannes Kirchmair, Jonny Proppe   +2 more
wiley   +1 more source

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

EFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Ellen Bruzell, James Chipman, Karlien Cheyns, Riccardo Crebelli, Cristina Fortes, Peter Fürst, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Manuela Mirat, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Romina Shah, Heather Wallace, Matthew Wright, Stefania Barmaz, Consuelo Civitella, Petra Georgelova, Federica Lodi, Elena Mazzoli, Josef Rasinger, Ana Maria Rincon, Alexandra Tard, Panagiota Zakidou, Maged Younes   +42 more
wiley   +1 more source

Mixed species biofilms act as planktonic cell factories despite isothiazolinone exposure under continuous‐flow conditions

Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.
Typical monitoring of biofouling in industrial water systems relies on planktonic cell concentrations, with remedial biocide application when microbial counts exceed the threshold. This study, along with others, confirms that biofilms act as ‘cell factories’, releasing planktonic cells even when exposed to antimicrobials.
Kyle B. Klopper, Elanna Bester, Martha van Schalkwyk, Gideon M. Wolfaardt   +3 more
wiley   +1 more source

Minoo industrial wastewater treatment plant: Introduction, process review, chemical monitoring, physicochemical monitoring and microbial characteristics monitoring

Desalination and Water Treatment
In this research, the quality of each stage and the final effluent of Mino's industrial waste water treatment plant is comprehensively investigated. In this regard, the water quality of the waste water treatment plant is examined from the point of view ...
Sara Nazari, Majid Ghahraman Afshar, Naser Harzandi   +2 more
doaj   +1 more source

Effect of the isotiazole adjuvants in combination with cisplatin in chemotherapy of neuroepithelial tumors: experimental results and modeling. [PDF]

Sci Rep, 2023
Potkin V, Pushkarchuk A, Zamaro A, Zhou H, Kilin S, Petkevich S, Kolesnik I, Michels DL, Lyakhov DA, Kulchitsky VA.   +9 more
europepmc   +1 more source

Catalyst-Free Trans-Selective Oxyiodination and Oxychlorination of Alkynes Employing N-X (Halogen) Reagents. [PDF]

Molecules, 2023
Sun J, Guo Y, Xia J, Zheng G, Zhang Q.
europepmc   +1 more source