Results 61 to 70 of about 1,392 (198)

2-((3R,9bS)-5,5-Dioxido-2,3-dihydro-9bH-benzo[4,5]isothiazolo[3,2-b]oxazol-3-yl)-1-phenylethan-1-one

Molbank
A highly efficient method has been developed for preparing 2-((3R,9bS)-5,5-dioxido-2,3-dihydro-9bH-benzo[4,5]isothiazolo[3,2-b]oxazol-3-yl)-1-phenylethan-1-one.
Yeongju Kim, Sung-Gon Kim
doaj   +1 more source

Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies

Drug Development Research, Volume 86, Issue 1, February 2025.
ABSTRACT In this study, hydrazine clubbed thiazole derivatives (3a–3j) were obtained by Hantzsch thiazole synthesis and characterized by MS, 1H NMR, and 13C NMR. The inhibitory potentials of the derivatives against diabetes‐related enzymes such as aldose reductase (AR), α‐glycosidase (α‐GLY), and α‐amylase (α‐AMY) were experimentally determined, and ...
Betül Kaya, Hakan Tahtacı, Bilge Çiftçi, Hatice Esra Duran, Adem Necip, Mesut Işık, Şükrü Beydemir   +6 more
wiley   +1 more source

Computational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide

, 2005
The mechanism for the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide has been investigated on the basis of ab initio, MP2 and DFT calculations.
Pasqualina Trimarco, TRIMARCO, PASQUALINA, Alessandro Contini, A. Contini, F. Clerici, Maurizio Sironi, Francesca Clerici, M. Sironi   +7 more
core   +1 more source

The terapeutic potential of isothiazole derivatives : the effect of compound structure on activity [PDF]

, 2018
Isothiazole derivatives are compounds with potentially interesting biological activity. The work on the isothiazole ring was successfully conducted by Machoń from the Department of Organic Chemistry at Wrocław Medical University.
Mączyński, M., Jęśkowiak, I., Ryng, S.   +2 more
core  

Enantioselective synthesis, chiroptical properties and absolute configuration of 3-aminosubstituted isothiazole S-oxides

, 2009
Herein we report a mild and efficient method to synthesize chiral 3-aminosubstituted isothiazole sulfoxides taking advantage of (+)- and (-)-((8,8-dichlorocamphoryl)sulfonyl)oxaziridine under microwave irradiation.
G. Celentano, M.L. Gelmi, Contini, Alessandro, C. Rosini, Casoni, Alessandro, Clerici, Francesca, Pellegrino, Sara, Celentano, Giuseppe, Gelmi, Maria Luisa, A. Casoni, A. Contini, F. Clerici, G. Mazzeo, Rosini, Carlo, S. Pellegrino, MAZZEO, Giuseppe, Sara Pellegrino, Maria Luisa Gelmi, Giuseppe Celentano, Francesca Clerici, Alessandro Contini, Carlo Rosini, Alessandro Casoni, Giuseppe Mazzeo   +23 more
core   +1 more source

Pd-catalysed cross-coupling reactions on isothiazole derivatives and their reactivity towards amino nucleophiles

, 2008
Als Modellstruktur für die vorliegende Dissertation diente die literaturbekannte Wirksubstanz CGP 60474 vom Typ der Pyridylpyrimidinamine, die schon in vielfältiger Weise modifiziert wurde.
Flašík, Radoslav
core   +2 more sources

Discovery of novel benzosultam CRBN ligands

Bulletin of the Korean Chemical Society, Volume 46, Issue 1, Page 48-56, January 2025.
Five novel benzosultam CRBN ligands were synthesized and evaluated their CRBN binding affinities. The 5‐amino benzosultam ligand (5b) demonstrated a CRBN binding affinity over 20 times stronger than lenalidomide. Molecular docking studies suggest the enhanced binding affinities could be from an additional hydrogen bond of benzosultams with Trp400 of ...
Hoyeong Park, Santosh Shivanand Raikar, Yonghyo Kim, Chong Hak Chae, Yong‐Hee Cho, Pilho Kim   +5 more
wiley   +1 more source

One-Step Synthesis of 2-Alkenecarbodithioate Esters from Substituted Propargyl Ethers, and Their Conversion into Isothiazole Ring through a [4+1] Type Oxidative Ring Closure

Natural Product Communications, 2017
Treatment of substituted propargyl methyl ethers with a base and elemental sulfur in the presence of a thiolate ion afforded 2-alkenecarbodithioate esters in good yields.
Kazuaki Shimada, Fumiya Ishikawa, Md. Ashraful Alam, Toshinobu Korenaga   +3 more
doaj   +1 more source

Pentathiepins are an understudied molecular prism of biological activities

Archiv der Pharmazie, Volume 357, Issue 12, December 2024.
Pentathiepins are cyclic sulfur‐rich compounds that possess remarkable chemical stability, unique structural features, and an extraordinary variety of biological activities. Nonetheless, they have only drawn the attention of the scientific community on a few occasions, generally after the serendipitous discovery of some of their properties. This review
Luca Pozzetti, Christopher R. M. Asquith
wiley   +1 more source

Unexpected formation of alkynyl-substituted 3-ylidenedihydrobenzo[ d]isothiazole 1,1-dioxides

, 2016
The isothiazole chemistry has been some progress from the year 1956 and since then, their chemical and physical properties have been extensively studied. Due to their particular reactivity, isothiazoles have recently emerged as useful synthetic compounds
Dassonneville, Benjamin, Etse, Koffi Senam, Zaragoza, Guillermo, Demonceau, Albert   +3 more
core