Results 51 to 60 of about 1,345 (190)

3-(4-Methylphenyl)-5-phenyl-1,2-thiazole

IUCrData
The title compound, C16H13NS, crystallizes in the monoclinic space group P21/c with two independent molecules in the asymmetric unit. Both molecules adopt a non-planar structure. No classical hydrogen bonds are found in the crystal structure.
A. S. Jeevan Chakravarthy, N. R. Sreenatha   +1 more
doaj   +1 more source

Rational Design of Low-Band Gap Star-Shaped Molecules With 2,4,6-Triphenyl-1,3,5-triazine as Core and Diketopyrrolopyrrole Derivatives as Arms for Organic Solar Cells Applications

Frontiers in Chemistry, 2019
A series of D–A novel star-shaped molecules with 2,4,6-triphenyl-1,3,5-triazine (TPTA) as core, diketopyrrolo[3,4-c]pyrrole (DPP) derivatives as arms, and triphenylamine (TPA) derivatives as end groups have been systematically investigated for organic ...
Xinhao Zhang, Xinhao Zhang, Ruifa Jin, Ruifa Jin   +3 more
doaj   +1 more source

Photochemical Conversion of Indazoles into Benzimidazoles

Angewandte Chemie International Edition, Volume 64, Issue 29, July 14, 2025.
We present a photochemical strategy for transforming 1H‐ and 2H‐indazoles into benzimidazoles, enabling heteroaromatic interconversion under mild conditions. This approach, grounded in a two‐step mechanism of excited‐state tautomerization and photochemical rearrangement, offers broad scope, high yields, and functional group tolerance, expanding the ...
Thiago dos Santos, Cornelia S. Buettner, Dilara Berna Yildiz, Martina Mamone, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase

, 2002
A series of isothiazole dioxides was synthesized and evaluated as inhibitors of protein farnesyltransferase from the parasite that causes African sleeping sickness (Trypanosoma brucei). The most potent compound in the series inhibited the parasite enzyme
M.L. Gelmi, M. H. Gelb, F. Clerici, D. Pocar, K. Yokoyama, W. C. Van Voorhis, F. S. Buckner   +6 more
core   +1 more source

Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.

PLoS ONE, 2012
Tip60 (KAT5) is a histone acetyltransferase (HAT enzyme) involved in multiple cellular processes including transcriptional regulation, DNA damage repair and cell signalling.
Kelly Coffey, Timothy J Blackburn, Susan Cook, Bernard T Golding, Roger J Griffin, Ian R Hardcastle, Lorraine Hewitt, Kety Huberman, Hesta V McNeill, David R Newell, Celine Roche, Claudia A Ryan-Munden, Anna Watson, Craig N Robson   +13 more
doaj   +1 more source

Unified Gold-Catalyzed Cyclization Approach Towards Isothiazoles from Propargylic Sulfinamides

CHIMIA
Isothiazoles are valuable heterocycles in agrochemical and pharmaceutical research, yet they remain synthetically less accessible than their isoxazole counterparts. We report here a gold-catalyzed cyclization of propargylic N-tert-butanesulfinamides that
Nada Saïdi, Thomas Simonet, Daniel P. Kloer, Mark Montgomery, Myriem El Qacemi   +4 more
doaj   +1 more source

Synthesis and biological profile of substituted hexahydrofuro[3,4‐b]furans, a novel class of bicyclic acyl‐acyl carrier protein (ACP) thioesterase inhibitors

Pest Management Science, Volume 81, Issue 5, Page 2635-2651, May 2025.
The present work covers a series of novel herbicidal lead structures that possess a hexahydrofuro[3,4‐b]furan scaffold as a structural key feature, carrying ortho‐substituted aryloxy side chains. Based on an optimized synthetic approach a broader structure–activity relationship (SAR) study was carried out delivering some lead structures that show good ...
Hartmut Ahrens, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Rahel Getachew, Hendrik Helmke, Sabine Hohmann, Bernd Laber, Gudrun Lange, Shaun Rees, Anna M. Reingruber, Dirk Schmutzler, Jens Frackenpohl   +13 more
wiley   +1 more source

Asymmetric synthesis and absolute configuration of 3-aminosubstituted isothiazole S-oxides

, 2009
Taking into account the importance in medicinal- and agro-chemistry of optically active isothiazole derivatives, we became interested in the asymmetric preparation of 3-aminosubstituted isothiazole 1-oxides [1].
G. Celentano, C. Rosini, A. Casoni, A. Contini, F. Clerici, G. Mazzeo, S. Pellegrino   +6 more
core   +2 more sources

Pd-catalysed cross-coupling reactions on isothiazole derivatives and their reactivity towards amino nucleophiles

, 2008
Als Modellstruktur für die vorliegende Dissertation diente die literaturbekannte Wirksubstanz CGP 60474 vom Typ der Pyridylpyrimidinamine, die schon in vielfältiger Weise modifiziert wurde.
Flašík, Radoslav
core   +4 more sources

Analysis of Volatile Components From Different Commercially Available Fenugreek Tinctures Based on GC‐IMS and SPME‐GC–MS and Their Correlation With Sensory Aroma

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
This study examines the variations in the key volatile flavor compounds of several fenugreek tincture samples from various sources and their relationship with flavor characterization using GC‐IMS, SPME‐GC–MS, OAV, and DSA. This study elaborates on the intrinsic association between key flavor components and sensory flavor, as well as the contributions ...
Hua Zhang, Haifeng Shen, Yuanqing Ye, Fan Cao, Jiale Ren, Huaiyuan Zhu, Bo Chi, Huiyun Liao, Feng Li   +8 more
wiley   +1 more source