Results 51 to 60 of about 1,392 (198)

Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.

PLoS ONE, 2012
Tip60 (KAT5) is a histone acetyltransferase (HAT enzyme) involved in multiple cellular processes including transcriptional regulation, DNA damage repair and cell signalling.
Kelly Coffey, Timothy J Blackburn, Susan Cook, Bernard T Golding, Roger J Griffin, Ian R Hardcastle, Lorraine Hewitt, Kety Huberman, Hesta V McNeill, David R Newell, Celine Roche, Claudia A Ryan-Munden, Anna Watson, Craig N Robson   +13 more
doaj   +1 more source

Unified Gold-Catalyzed Cyclization Approach Towards Isothiazoles from Propargylic Sulfinamides

CHIMIA
Isothiazoles are valuable heterocycles in agrochemical and pharmaceutical research, yet they remain synthetically less accessible than their isoxazole counterparts. We report here a gold-catalyzed cyclization of propargylic N-tert-butanesulfinamides that
Nada Saïdi, Thomas Simonet, Daniel P. Kloer, Mark Montgomery, Myriem El Qacemi   +4 more
doaj   +1 more source

Synthesis and biological profile of substituted hexahydrofuro[3,4‐b]furans, a novel class of bicyclic acyl‐acyl carrier protein (ACP) thioesterase inhibitors

Pest Management Science, Volume 81, Issue 5, Page 2635-2651, May 2025.
The present work covers a series of novel herbicidal lead structures that possess a hexahydrofuro[3,4‐b]furan scaffold as a structural key feature, carrying ortho‐substituted aryloxy side chains. Based on an optimized synthetic approach a broader structure–activity relationship (SAR) study was carried out delivering some lead structures that show good ...
Hartmut Ahrens, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Rahel Getachew, Hendrik Helmke, Sabine Hohmann, Bernd Laber, Gudrun Lange, Shaun Rees, Anna M. Reingruber, Dirk Schmutzler, Jens Frackenpohl   +13 more
wiley   +1 more source

Isothiazole dioxides: Synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase

, 2002
A series of isothiazole dioxides was synthesized and evaluated as inhibitors of protein farnesyltransferase from the parasite that causes African sleeping sickness (Trypanosoma brucei). The most potent compound in the series inhibited the parasite enzyme
M.L. Gelmi, M. H. Gelb, F. Clerici, D. Pocar, K. Yokoyama, W. C. Van Voorhis, F. S. Buckner   +6 more
core   +1 more source

In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative [PDF]

, 2003
We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolated tested. Killing experiments showed that fungicidal
PIZZO G., SCHIMIZZI A. M., VICENTINI C. B., BARCHIESI F., VICENTINI, Chiara Beatrice, SCALISE G., ARZENI D., GIANNINI D., MANFRINI M., GIAMMANCO G. M., SCHIMIZZI A. M. ., MILICI M. E., Manfrini, Maurizio, Milici, Maria E., Giannini, Daniele, Arzeni, Daniela, Schimizzi, Anna M., Pizzo, Giuseppe, Giammanco, Giovanni, Barchiesi, Francesco, Vicentini, Chiara B., Scalise, Giorgio   +21 more
core   +2 more sources

Analysis of Volatile Components From Different Commercially Available Fenugreek Tinctures Based on GC‐IMS and SPME‐GC–MS and Their Correlation With Sensory Aroma

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
This study examines the variations in the key volatile flavor compounds of several fenugreek tincture samples from various sources and their relationship with flavor characterization using GC‐IMS, SPME‐GC–MS, OAV, and DSA. This study elaborates on the intrinsic association between key flavor components and sensory flavor, as well as the contributions ...
Hua Zhang, Haifeng Shen, Yuanqing Ye, Fan Cao, Jiale Ren, Huaiyuan Zhu, Bo Chi, Huiyun Liao, Feng Li   +8 more
wiley   +1 more source

Studies on Heterocyclic Compounds. Part-VII* : Spasmolytic Activities of Isothiazole Carboxylic Esters

, 1983
Biochemistry Laboratory, Sambalpur University, Sambalpur-768 017 Manuscript received 5 October 1982, accepted 19 July 1983 Several isothiazole esters have been synthesised with a view to evaluate their spasmolytic activities against acetylcholine ...
S. S. MEHER, S. K. NAIK, A. NAYAK
core   +1 more source

The synthesis of several members of the new imidazo(4,5-d)isothiazole ring system: Novel 5:5 fused analogs of purines and purine nucleosides.

, 1994
The chemistry of purines, purine nucleosides, and their derivatives has been extensively studied, and many analogs of this important class of compounds exert a significant biological effect.
Swayze, Eric Edward
core   +4 more sources

Synthesis of Novel Vanillin Derivatives Containing Isothiazole Moieties and its Synergistic Effect in Mixtures with Insecticides

Natural Product Communications, 2009
Reaction between 4-formyl-2-methoxyphenyl 4,5-dichloroisothiazole-3-carboxylate with various aromatic amines led to azomethins 2-7 formation. By treatment of azomethins 2-7 with sodium triacetoxyborohydride corresponding amines 8-11 were obtained. During
Vladimir Potkin, Yuri Zubenko, Anatoly Bykhovetz, Romualda Zolotar, Violetta Goncharuk   +4 more
doaj   +1 more source

Conventional and innovative approaches to black fungi control for stone heritage preservation

IUBMB Life, Volume 77, Issue 3, March 2025.
Abstract Black Meristematic Fungi (BMF) are characterized by a thick melanized cell wall and an isodiametric cellular expansion. BMF represent one of the most damaging groups of microorganisms causing the deterioration of outdoor exposed stone monuments mainly due to the formation of dark spots and patches leading to the darkening of their surface ...
Domenico Celi, Massimiliano Marvasi, Brunella Perito   +2 more
wiley   +1 more source