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Synthesis of Polyfunctionalized Amino Furans with Long Conjugated Aromatic Systems Using Nucleophilic Aromatic Isocyanide [PDF]
E-Journal of Chemistry, 2012 Polyfunctionalized amino furans with long conjugated aromatic systems have been synthesized by three component reaction of aldehydes, acetylenic esters and aromatic nucleophilic isocyanide.
Mohammad Qandalee +3 more
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Reactions of 4H-1,2,6-Thiadiazine Sulfides
Molbank, 2022 3,5-Dichloro-4H-1,2,6-thiadiazin-4-one reacts with benzo[d]thiazole-2-thiol (1 equiv) and triethylamine (1 equiv) to give 3-(benzo[d]thiazol-2-ylthio)-5-chloro-4H-1,2,6-thiadiazin-4-one in 71% yield.
Andreas S. Kalogirou +1 more
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Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride with 2-(Phenylsulfonyl)acetonitrile
Molbank, 2022 The reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-(phenylsulfonyl)acetonitrile (1 equiv) in the presence of pyridine (2 equiv) gave S-(3-chloro-5-cyanoisothiazol-4-yl)benzenesulfonothioate and (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-2-
Konstantinos Plakas +3 more
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2-Amino-5-chloro-1H-pyrrole-3,4-dicarbonitrile
Molbank, 2021 The reaction of tetracyanoethylene (TCNE) with HCl (g) in the presence of Sn (1 equiv) and AcOH resulted in 2-amino-5-chloro-1H-pyrrole-3,4-dicarbonitrile in a 74% yield. The compound was fully characterized.
Andreas S. Kalogirou +1 more
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Methyl 3-Bromo-5-carbamoylisothiazole-4-carboxylate
Molbank, 2023 Reaction of methyl 3-bromo-5-cyanoisothiazole-4-carboxylate with conc. H2SO4 gave methyl 3-bromo-5-carbamoylisothiazole-4-carboxylate in 93% yield. The compound was fully characterized.
Andreas S. Kalogirou +1 more
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Molecules, 2022 A solvent-free two-step synthesis of polyfunctionalized pyrazoles under ball-milling mechanochemical conditions was developed. The protocol comprises (3 + 2)-cycloaddition of in situ generated nitrile imines and chalcones, followed by oxidation of the ...
Greta Utecht-Jarzyńska +2 more
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Synthesis and cyclization reactions of 2-(6-methylquinolin-4-yl)malononitriles and ethyl 2-cyano-2-(6-methylquinolin-4-yl)acetates [PDF]
Journal of the Serbian Chemical Society, 2006 The nucleophilic substitution reactions of 2,4-dichloro-6-methylquinoline (1) and 4-chloro-6-methylquinolin-2(1H)-one (7) with malononitrile and ethyl cyanoacetate are described. The quinolinylmalononitrile 8a and cyanoacetate 8b were utilized to prepare
MOSTAFA M. ISMAIL
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Evaluating Cellular Polyfunctionality with a Novel Polyfunctionality Index
PLoS ONE, 2012 Functional evaluation of naturally occurring or vaccination-induced T cell responses in mice, men and monkeys has in recent years advanced from single-parameter (e.g. IFN-γ-secretion) to much more complex multidimensional measurements. Co-secretion of multiple functional molecules (such as cytokines and chemokines) at the single-cell level is now ...
Larsen, Martin +5 more
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Molecules, 2023 Sequential reactions of aminoalkynes represent a powerful tool to easily assembly biologically important polyfunctionalized nitrogen heterocyclic scaffolds.
Antonio Arcadi +2 more
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Antioxidants, 2022 Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more
Daniel Diez-Iriepa +8 more
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