Synthesis of Polyfunctionalized Amino Furans with Long Conjugated Aromatic Systems Using Nucleophilic Aromatic Isocyanide [PDF]
E-Journal of Chemistry, 2012 Polyfunctionalized amino furans with long conjugated aromatic systems have been synthesized by three component reaction of aldehydes, acetylenic esters and aromatic nucleophilic isocyanide.
Mohammad Qandalee +3 more
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Pd/C-Catalyzed Hydrogenation of CF<sub>3</sub>-, CF<sub>2</sub>H-, and CF<sub>2</sub>CO<sub>2</sub>Et-containing Pyridines: A Robust Method for Highly Functionalized containing Piperidines. [PDF]
Angew Chem Int Ed EnglA robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Charvillat T +7 more
europepmc +2 more sources
(E)-4-Oxo-3,4-dihydroquinazoline-2-carbaldehyde Oxime
Molbank, 2021 Reaction of 4-oxo-3,4-dihydroquinazoline-2-carbaldehyde with hydroxylamine hydrochloride (1.1 equiv) in the presence of K2CO3 (1 equiv) gave (E)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde oxime (8) in 58% yield.
Andreas S. Kalogirou +2 more
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, 2016 The addition of 0.5 equiv of TiCl4 to (cyclo)alkanones tethered to α,β-unsaturated ketones afforded polyfunctionalized diquinanes, hydrindanes, and decalines.
Alexis Jaunet (1867663) +4 more
core +9 more sources
Reactions of 4H-1,2,6-Thiadiazine Sulfides
Molbank, 2022 3,5-Dichloro-4H-1,2,6-thiadiazin-4-one reacts with benzo[d]thiazole-2-thiol (1 equiv) and triethylamine (1 equiv) to give 3-(benzo[d]thiazol-2-ylthio)-5-chloro-4H-1,2,6-thiadiazin-4-one in 71% yield.
Andreas S. Kalogirou +1 more
doaj +1 more source
Contilisant+Tubastatin A hybrids, as new multi-target-directed polyfunctionalized indole derivatives able to inhibit histone deacetylase/cholinesterase/monoamine oxidase enzymes, and modulate histamine 3/sigma 1/5-HT6/dopamine 3 receptors for the treatment of cancer [PDF]
, 2023 Herein we describe the design and synthesis of Contilisant+Tubastatin A hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers, such as glioblastoma.
Ander , Matheu +10 more
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Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride with 2-(Phenylsulfonyl)acetonitrile
Molbank, 2022 The reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-(phenylsulfonyl)acetonitrile (1 equiv) in the presence of pyridine (2 equiv) gave S-(3-chloro-5-cyanoisothiazol-4-yl)benzenesulfonothioate and (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-2-
Konstantinos Plakas +3 more
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2-Amino-5-chloro-1H-pyrrole-3,4-dicarbonitrile
Molbank, 2021 The reaction of tetracyanoethylene (TCNE) with HCl (g) in the presence of Sn (1 equiv) and AcOH resulted in 2-amino-5-chloro-1H-pyrrole-3,4-dicarbonitrile in a 74% yield. The compound was fully characterized.
Andreas S. Kalogirou +1 more
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Methyl 3-Bromo-5-carbamoylisothiazole-4-carboxylate
Molbank, 2023 Reaction of methyl 3-bromo-5-cyanoisothiazole-4-carboxylate with conc. H2SO4 gave methyl 3-bromo-5-carbamoylisothiazole-4-carboxylate in 93% yield. The compound was fully characterized.
Andreas S. Kalogirou +1 more
doaj +1 more source
Molecules, 2022 A solvent-free two-step synthesis of polyfunctionalized pyrazoles under ball-milling mechanochemical conditions was developed. The protocol comprises (3 + 2)-cycloaddition of in situ generated nitrile imines and chalcones, followed by oxidation of the ...
Greta Utecht-Jarzyńska +2 more
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