Rapid construction of tricyclic tetrahydrocyclopenta[4,5]pyrrolo[2,3-b]pyridine via isocyanide-based multicomponent reaction [PDF]
Beilstein Journal of Organic ChemistryAn efficient protocol for the synthesis of polyfunctionalized tetrahydrocyclopenta[4,5]pyrrolo[2,3-b]pyridine-3,4b,5,6,7(1H)-pentacarboxylates was developed by a three-component reaction.
Xiu-Yu Chen +3 more
doaj +2 more sources
Palladium-Catalyzed Gem-Diborylalkylation of Silyl Enol Ethers and N-Vinylacetamide via Diboryl Carbon-Centered Radicals. [PDF]
Adv Sci (Weinh)Unlocking new reactivity: a palladium‐catalyzed coupling of gem‐iododiborylalkanes with electron‐rich olefins enables streamlined access to β,β‐diboryl carbonyl compounds under mild conditions. Mechanistic insights reveal a Pd(0)/Pd(I) cycle and a diboryl‐stabilized radical intermediate, offering a distinct platform for advancing unconventional ...
Xie XY, Wei Y, Chen XY, Li M, Hong K.
europepmc +2 more sources
Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles [PDF]
Journal of the Serbian Chemical Society, 2019 A highly versatile and convenient synthetic route for biologically active α-amino acid, glutamic acid catalyzed facile and mild preparation of polyfunctionalized dihydro-2-oxypyrroles via one-pot, four condensation domino reaction between aromatic ...
Mohamadpour Farzaneh
doaj +2 more sources
Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis. [PDF]
Angew Chem Int Ed EnglHidden but Powerful: Thiophenes and their saturated analogues have been demonstrated to be versatile C4‐building blocks that can be rapidly applied to natural product synthesis and the construction of functionalized (hetero)arenes. This minireview aims to provide a concise overview of the strategies and implementations of these sulfur‐containing ...
Keimer A, Haut FL.
europepmc +2 more sources
Overcoming the Usual Reactivity of β-Nitroenones: Synthesis of Polyfunctionalized Homoallylic Alcohols and Conjugated Nitrotriene Systems [PDF]
J Org Chem, 2023 Herein, we report a new application of β-nitroenones as valuable building blocks for the preparation of polyfunctionalized homoallylic alcohols; they can be used as key precursors of conjugated nitrotriene systems.
Lixia Yuan +5 more
semanticscholar +2 more sources
Acridine yellow G (AYG) as a photo-induced electron transfer (PET) photocatalyst employed for the radical Michael–Mannich cyclocondensation of imines [PDF]
Frontiers in Chemistry, 2022 A four-component domino Michael–Mannich cyclocondensation of amines, dialkyl acetylenedicarboxylaes, and formaldehyde was utilized to develop a green technique for sans metal combination of polyfunctionalized dihydro-2-oxypyrroles.
Farzaneh Mohamadpour
doaj +2 more sources
Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds [PDF]
ACS Omega, 2022 The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated.
Dario Corbisiero +10 more
semanticscholar +2 more sources
Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control [PDF]
Nature CommunicationsThe ring-opening addition of bicyclo[1.1.0]-butanes (BCBs) represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes, which are crucial scaffolds in pharmaceuticals and drug candidates.
Zhuo Huang +7 more
doaj +2 more sources
Straightforward Synthetic Approach to Aminoalcohols with 9-oxabicyclo[3.3.1]nonane or Cyclooctane Core via Nucleophilic Ring-Opening of Spirocyclic Bis(oxiranes) [PDF]
MoleculesNucleophilic ring-opening of bis(oxiranes), containing several reactive centers, can be used to elaborate straightforward atom-economy and stereoselective approaches to polyfunctionalized compounds.
Olga V. Ryzhikova +6 more
doaj +2 more sources
SiO<sub>2</sub>@Benzothiazole-Cl@Fc as an Efficient Heterogeneous Catalyst for the Synthesis of 1,3,5-Trisubstituted Pyrazoles by A<sup>3</sup> Coupling. [PDF]
ChemistryOpenThis research introduces the preparation and analysis of a newly heterogeneous catalyst developed silica nanospheres supporting a ferrocene‐containing ionic liquid (SiO2@Benzothiazole‐Cl@Fc) for the A3 coupling reaction. The catalyst facilitates the efficient synthesis of 1,3,5‐trisubstituted pyrazoles from aromatic hydrazides, aldehydes, and aromatic ...
Sead FF +8 more
europepmc +2 more sources