Results 21 to 30 of about 1,953 (209)

(Z)-2-{[(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino](methylthio)methylene}malononitrile

Molbank, 2022
Reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with 2-[amino(methylthio)methylene])malononitrile (1 equiv) in the presence of pyridine (2 equiv) gave (Z)-2-{[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino](methylthio)methylene}malononitrile in 20 ...
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

(E)-4-Oxo-3,4-dihydroquinazoline-2-carbaldehyde Oxime

Molbank, 2021
Reaction of 4-oxo-3,4-dihydroquinazoline-2-carbaldehyde with hydroxylamine hydrochloride (1.1 equiv) in the presence of K2CO3 (1 equiv) gave (E)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde oxime (8) in 58% yield.
Andreas S. Kalogirou, Andreas Kourtellaris, Panayiotis A. Koutentis   +2 more
doaj   +1 more source

Contilisant+Tubastatin A hybrids, as new multi-target-directed polyfunctionalized indole derivatives able to inhibit histone deacetylase/cholinesterase/monoamine oxidase enzymes, and modulate histamine 3/sigma 1/5-HT6/dopamine 3 receptors for the treatment of cancer [PDF]

, 2023
Herein we describe the design and synthesis of Contilisant+Tubastatin A hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers, such as glioblastoma.
Ander , Matheu, Abdelouahid, Samadi, Isabel I, Iriepa, Mireia , Toledano-Pinedo, Alicia , Porro, Aizpea , Artetxe-Zurutuza, José Luis, Marco-Contelles, Fernando , Romero, Pedro , Almendros, M. Mercedes , Rodríguez-Fernández, Francisco, López-Muñoz   +10 more
core   +2 more sources

Contilistat, a new polyfunctionalized histone deacetylase inhibitor, showing potential capacity to inhibit cholinesterase/monoamine oxidase enzymes, and modulate histamine 3, sigma 1, 5-HT6 and dopamine 3 receptors for the treatment of cancer and neurodegenerative diseases [PDF]

, 2023
The present work describes the design, and synthesis of the polyfunctionalized indole derivative Contilistat for the treatment of a broad diversity of cancers, and neurodegenerative diseases such as glioblastoma, and Alzheimer’s disease (AD). Contilistat
Ander, Matheu, M. Mercedes , Rodríguez-Fernández,, Daniel, Diez-Iriepa, Abdelouahid , Samadi, Mireia, Toledano-Pinedo, Alicia, Porro, Aizpea , Artetxe-Zurutuza, Isabel , Iriepa, José , Marco-Contelles, Pedro , Almendros, Francisco , López-Muñoz   +10 more
core   +2 more sources

Direct CH Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Bronsted Bases

, 2022
CO2 fixation into electron-deficient aromatic C–H bonds proceeds with the combined Brønsted bases LiO-t-Bu and LiO-t-Am/CsF/18-crown-6 (t-Am = CEtMe2) under a CO2 atmosphere to afford a variety of polyfunctionalized aromatic carboxylic ...
Masanori Shigeno, Masanori Shigeno (1797376), Kazuya Hanasaka (11977741), Eunsang Kwon (1632397), Kanako Nozawa-Kumada (1528876), Koki Izumi (11977747), Yoshinori Kondo, Itsuki Tohara (11977744), Itsuki Tohara, Hiroyuki Yamakoshi, Hiroyuki Yamakoshi (1825975), Kanako Nozawa-Kumada, Kazuya Hanasaka, Koki Izumi, Eunsang Kwon, Yoshinori Kondo (1528870)   +15 more
core   +1 more source

Z‐Retentive Enantioselective Rh‐Catalyzed Hydroarylation of E,Z‐Dienes

Angewandte Chemie, EarlyView.
The Rh‐catalyzed hydroarylation of conjugated E,Z‐dienoates is found to proceed with high selectivity for addition to the E‐alkene unit. Mechanistic analysis of this Z‐retentive process points towards preferred binding of the E‐alkene unit to a Rh‐aryl species to give rise to the observed selectivity and that Rh‐enolate protonolysis to be turnover ...
Wesley McNutt, Hima Kozhummal, Abdullah Al‐Mashqbeh, Alex Brown, Rylan J. Lundgren   +4 more
wiley   +2 more sources

Affix polyfunctionality in French deverbal nominalizations

Morphology, 2022
AbstractThis article investigates the semantic polyfunctionality of affixes, i.e. their ability to serve a variety of distinct semantic functions. Based on the analysis of a sample of 3,091 deverbal nouns ending with 46 different suffixes in French, the study examines the diversity of semantic functions realized by deverbal suffixes, the distribution ...
Justine Salvadori, Richard Huyghe
openaire   +2 more sources

Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles [PDF]

Journal of the Serbian Chemical Society, 2019
A highly versatile and convenient synthetic route for biologically active α-amino acid, glutamic acid catalyzed facile and mild preparation of polyfunctionalized dihydro-2-oxypyrroles via one-pot, four condensation domino reaction between aromatic ...
Mohamadpour Farzaneh
doaj   +1 more source

Green Organoselenium Chemistry: Selective Syntheses of New 1,4-Thiaselenine Derivatives Based on Reactions of Thiaselenole Reagent with Alcohols and Water

Inorganics, 2023
Environmentally friendly synthetic methods were developed for the selective preparation of new 2,3-dihydro-1,4-thiaselenine derivatives in high yields based on the reactions of 2-bromomethyl-1,3-thiaselenole with alcohols and water at room temperature ...
Svetlana V. Amosova, Andrey S. Filippov, Nataliya A. Makhaeva, Alexander I. Albanov, Vladimir A. Potapov   +4 more
doaj   +1 more source

Polyfunctionality of the English quantitative words

Journal of Education Culture and Society, 2020
The article in question considers the functioning of quantitative units, their language and speech aspects. Introduction focuses upon the major items of paper – definition of numerals, words of weight and measure, aims, methods of investigation, empiric mate-rial applied, evolution modifications, and perspectives of further study.
openaire   +3 more sources