Results 31 to 40 of about 1,953 (209)

5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile)

Molbank
The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with bromine (2 equiv.) in CCl4 gave 3,5-dibromoisothiazole-3-carbonitrile and 5,5′-thiobis(3-bromoisothiazole-4-carbonitrile) in 7% and 18% yields, respectively.
Andreas S. Kalogirou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Radical Smiles Rearrangement: An Update

Molecules, 2016
Over the decades the Smiles rearrangement and its variants have become essential synthetic tools in modern synthetic organic chemistry. In this mini-review we summarized some very recent results of the radical version of these rearrangements.
Ingrid Allart-Simon, Stéphane Gérard, Janos Sapi   +2 more
doaj   +1 more source

One-Pot Synthesis of Polyfunctionalized Isoxazol(in)es¹

, 2016
One-Pot Synthesis of Polyfunctionalized Isoxazol(in ...
Yasuo Tohda (3046575), Masahiro Ariga (1837369), Noriko Asaka (3046566), Nagatoshi Nishiwaki (1662046), Tomoko Nogami (3046560), Takayasu Kawamura (3047496)   +5 more
core   +1 more source

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

Beilstein Journal of Organic Chemistry, 2016
Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good ...
Samantha Caputo, Andrea Basso, Lisa Moni, Renata Riva, Valeria Rocca, Luca Banfi   +5 more
doaj   +1 more source

A NOVEL RING TRANSFORMATION OF NITROPYRIMIDINONE LEADING TO POLYFUNCTIONALIZED PYRIDONES

, 2007
Polyfunctionalized 2-pyridones are readily prepared by the ring transformation using 3-methyl-5-nitropyrimidin-4(3H)-one with active methylene compounds in the presence of ...
NISHIWAKI, Nagatoshi, MATSUSHIMA, Kazuo, MORIMURA, Hiromi, TAMURA, Mina, ARIGA, Masahiro   +4 more
core   +1 more source

Contilisant+Belinostat hybrids, as new multi-target-directed polyfunctionalized indole derivatives able to inhibit histone deacetylase/cholinesterase/monoamine oxidase enzymes, and modulate histamine 3/sigma 1/5-HT6/dopamine 3 receptors for the treatment of cancer and neurodegenerative diseases [PDF]

, 2023
Herein we describe the design and synthesis of Contilisant+Belinostat hybrids as polyfunctionalized indole derivatives for the treatment of a broad diversity of cancers and neurodegenerative diseases, such as glioblastoma, and Alzheimer’s disease (AD ...
Ander, Matheu, Saray , Macaulet, Mireia , Toledano-Pinedo, Alicia , Porro, Aizpea , Artetxe-Zurutuza, Isabel , Iriepa, José , Marco-Contelles, Pedro , Almendros, M. Mercedes , Rodríguez-Fernández, Francisco , López-Muñoz   +9 more
core   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Acridine yellow G as a photo-induced electron transfer catalyzed radical [4 + 2] aza-Diels-Alder annulation of imines

Results in Chemistry
For the preparation of polyfunctionalized piperidine scaffolds, a radical tandem five-condensation domino Knoevenagel-intramolecular [4 + 2] aza-Diels-Alder imin-based reaction was used.
Farzaneh Mohamadpour
doaj   +1 more source

Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4-c]carbazoles via domino Diels–Alder reaction

Beilstein Journal of Organic Chemistry, 2021
The p-TsOH-catalyzed Diels–Alder reaction of 3-(indol-3-yl)maleimides with chalcone in toluene at 60 °C afforded two diastereoisomers of tetrahydropyrrolo[3,4-c]carbazoles, which can be dehydrogenated by DDQ oxidation in acetonitrile at room temperature ...
Ren-Jie Fang, Chen Yan, Jing Sun, Ying Han, Chao-Guo Yan   +4 more
doaj   +1 more source

Stereoselective Synthesis of Bridged Azepine Derivatives via Polyfunctionalized Spiroannulated Thiophene. Novel Rearrangement of Oxime Esters

, 2016
Stereoselective Synthesis of Bridged Azepine Derivatives via Polyfunctionalized Spiroannulated Thiophene.
Jacek Grochowski (3028836), Agnieszka Obara (3028839), Barbara Rys (1528537), Krystyna Bogdanowicz-Szwed (3028842), Paweł Serda (2028958)   +4 more
core   +1 more source