Results 151 to 160 of about 112,263 (200)
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Nature, 1965
THE ‘polygene’ hypothesis was proposed by Mather1 to explain the sudden responses to selection which occurred in his experiments and in those of Payne2. Similar patterns of response to selection have been found by Sismanidis3, Thoday and Boam4, and Fraser and Hansche5.
R, Nassar, A, Fraser
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THE ‘polygene’ hypothesis was proposed by Mather1 to explain the sudden responses to selection which occurred in his experiments and in those of Payne2. Similar patterns of response to selection have been found by Sismanidis3, Thoday and Boam4, and Fraser and Hansche5.
R, Nassar, A, Fraser
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Current Protocols, 2021
Abstract As genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent.
Michael D, Osterman +2 more
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Abstract As genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent.
Michael D, Osterman +2 more
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Current Opinion in Genetics & Development, 1993
Considerable success is now being achieved in defining genetic susceptibility loci in polygenic disease. In particular, new susceptibility loci have been identified in hypertension, type I and type II diabetes, asthma and malaria infection. The approaches and tools for mapping such susceptibility determinants are becoming more clearly defined and the ...
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Considerable success is now being achieved in defining genetic susceptibility loci in polygenic disease. In particular, new susceptibility loci have been identified in hypertension, type I and type II diabetes, asthma and malaria infection. The approaches and tools for mapping such susceptibility determinants are becoming more clearly defined and the ...
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Polygenic Inheritance of Otosclerosis
Annals of Otology, Rhinology & Laryngology, 1976A large family has been studied and its pedigree traced for six generations. Fifteen relatives are known to have had otosclerosis. Of these, the only six individuals who developed this disease before the age of twenty were offspring of second-cousin marriages.
J C, Mendlowitz, K, Hirschhorn
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Polygenic Mendelian Randomization
Cold Spring Harbor Perspectives in Medicine, 2020Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR.
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Polygenes and Polygenic Mutation
Abstract This chapter examines the polygenic mutational variance, a function of both mutation rate and the variance in effects per mutation. Estimation experiments are discussed, which provide some insight into the nature of quantitative variation.Bruce Walsh +2 more
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Polygenic influences on dyslipidemias
Current Opinion in Lipidology, 2018Purpose of review Rare large-effect genetic variants underlie monogenic dyslipidemias, whereas common small-effect genetic variants – single nucleotide polymorphisms (SNPs) – have modest influences on lipid traits. Over the past decade, these small-effect SNPs have been shown to cumulatively exert consistent effects on lipid ...
Jacqueline S, Dron, Robert A, Hegele
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Polygenic Inheritance in Neurospora
Nature, 1955ASCOSPORES of Neurospora crassa two to three times the normal size occur in many strains, though the frequency is low, probably less than one per thousand ascospores. A particular cross made in this laboratory produced an abnormally high frequency of giant ascospores (about 3.4 per cent), and since a number of these germinated and gave good cultures, a
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