Shared Genetics of Psychiatric Disorders [PDF]
, 2019 Until recently, advances in understanding the genetic architecture of psychiatric disorders have been impeded by a historic, and often mandated, commitment to the use of traditional, and unvalidated, categorical diagnoses in isolation as the relevant ...
Fuller, Tova, Reus, Victor
core
Autism Spectrum Disorder Among Gender‐Diverse Children and Adolescents: A National Cohort Study
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is more prevalent in transgender and gender‐diverse (TGD) individuals than in the general population, yet the specific developmental pathways within and clinical outcomes of this intersection are insufficiently understood.
Erez Topaz +7 more
wiley +1 more source
Improving the cost effectiveness equation of cascade testing for Familial Hypercholesterolaemia (FH) [PDF]
, 2015 Purpose of Review : Many International recommendations for the management of Familial Hypercholesterolaemia (FH) propose the use of Cascade Testing (CT) using the family mutation to unambiguously identify affected relatives.
Futema, M +3 more
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Brain Health, EarlyView.ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye +14 more
wiley +1 more source
The Liability Threshold Model for Censored Twin Data
, 2015 Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components.
Hjelmborg, Jacob B. +2 more
core +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Statistical genetics and polygenic risk score for precision medicine [PDF]
, 2021 Takahiro Konuma, Yukinori Okada
openalex +1 more source
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions [PDF]
, 2016 Genetic association studies provide evidence for a substantial polygenic component to schizophrenia, although the neurobiological mechanisms underlying the disorder remain largely undefined.
Al-Saraj, S +11 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples +10 more
wiley +1 more source
Combination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: A case –control study [PDF]
, 2020 Juan Carlos Triviño +24 more
openalex +1 more source