Results 111 to 120 of about 32,760 (257)

Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The clinical utility of the polygenic risk score in predicting cardiovascular events in patients with atrial fibrillation (AF) has not yet been established.
Juntae Kim, Dongmin Kim, Daehoon Kim, Byoung‐Eun Park, Tae Soo Kang, Seong‐Hoon Lim, Su Yeon Lee, Young Hak Chung, Myung‐Yong Lee, Pil‐Sung Yang, Boyoung Joung   +10 more
doaj   +1 more source

Investigating the impact of early adversity on perceived support from parents and friends in preadolescence: Do genetic predispositions and timing of exposure matter?

JCPP Advances, EarlyView.
This study found that youth with a higher genetic risk for internalizing and externalizing problems were more likely to face adversity within their home, highlighting the need for risk mitigation. These associations varied by adversity type and timing. Additionally, low family income, parental divorce, and externalizing behaviours were linked to lower ...
Christina Y. Cantave, Marthe de Roo, Charlotte Vrijen, Tina Kretschmer   +3 more
wiley   +1 more source

Polygenic Risk Scores: Genomes to Risk Prediction

Clinical Chemistry, 2023
Tristan J Hayeck, George B Busby, Sung Chun, Anna C F Lewis, Megan C Roberts, Bjarni J Vilhjálmsson   +5 more
openaire   +3 more sources

Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores

JCPP Advances, EarlyView.
Abstract Background Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic ...
Tom C.‐H. Wu, Deniz Konac, Liliana Garcia‐Mondragon, Alex F. Martin, Barbara Maughan, Ted Barker   +5 more
wiley   +1 more source

Transferability of polygenic risk score among diverse ancestries

Clinical and Translational Discovery, 2023
Xi Cheng, Sen Zhao
doaj   +1 more source

The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review

JCPP Advances, EarlyView.
Abstract Background Genetic epidemiological analyses of child and adolescent mental health often use data from prospective longitudinal cohorts. Missingness due to selective attrition is therefore an important potential source of bias in such analyses.
Meseret M. Bazezew, Adrian Dahl Askelund, Kate Tilling, Alexandra Havdahl, Laurie J. Hannigan   +4 more
wiley   +1 more source

Irritability in preschool children with attention‐deficit/hyperactivity disorder: Analysis of family environmental factors

JCPP Advances, EarlyView.
Abstract Background Irritability affects one‐third of children and adolescents with attention‐deficit/hyperactivity disorder (ADHD) and is associated with negative outcomes. The family environment plays a prominent role in the child's development, and therefore on the risk for irritability, especially during the preschool period.
Analin Ono Baraniuk, Giovanni Abrahão Salum, David Daley, Erika Mendonça de Morais, Filipe Jaeger Zabala, Luiz Eduardo de Souza, Guilherme V. Polanczyk, Luisa Shiguemi Sugaya   +7 more
wiley   +1 more source

Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies

Alzheimer’s Research & Therapy
Background The success of selecting high risk or early-stage Alzheimer’s disease individuals for the delivery of clinical trials depends on the design and the appropriate recruitment of participants.
Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao, Emily Simmonds, Ying Wu, Niklas Mattsson-Carlgren, Oskar Hansson, Michael W. Nagle, Valentina Escott-Price, the Alzheimer’s Disease Neuroimaging Initiative   +10 more
doaj   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

Polygenic Risk Scores in the Clinic

Neurology, 2023
Georgakis, Marios K., Anderson, Christopher D.   +1 more
openaire   +3 more sources