Results 131 to 140 of about 7,071,839 (288)

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

Risk score roulette: A cautionary tale of polygenic risk score reliability

Journal of Alzheimer’s Disease
Genetic risk prediction for Alzheimer's disease (AD) has high potential impact, yet few studies have assessed the reliability of various polygenic risk score (PRS) methods at the individual level. Here, we evaluated the reliability of AD PRS estimates among 6338 participants from the Multi-Ethnic Study of Atherosclerosis.
Diane Xue, Elizabeth E Blue, Alexis C Wood, Jerome I Rotter, Alison E Fohner   +4 more
openaire   +3 more sources

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Common cause versus dynamic mutualism: Insights into ADHD's common comorbidities

JCPP Advances, EarlyView.
Abstract Background Contemporary classification systems differ in their conceptualization of ADHD as either an externalizing or neurodevelopmental condition, with both perspectives promoting the common cause model as an explanation of ADHD's comorbidity.
Zheyue Peng, Ashley L. Watts
wiley   +1 more source

A pre-train and fine-tune framework for adaptive boosting of pre-trained polygenic risk scores

Nature Communications
Polygenic risk scores are widely used for predicting genetic risk across complex diseases and traits, and several pre-trained models have been developed.
Jie Hu, Raelynn Chen, Maxwell Salvatore, Olivia Wu, Okan Bilge Ozdemir, Yiwen Lu, Shawn N. Murphy, Elizabeth W. Karlson, Atlas Khan, Krzysztof Kiryluk, Iftikhar J. Kullo, Johanna L. Smith, Eimear E. Kenny, Yuan Luo, Zaldy S. Tan, William G. La Cava, Marylyn D. Ritchie, Yong Chen, Ruowang Li   +18 more
doaj   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Categories or dimensions? A critical systematic review of taxometric evidence in autism, ADHD, and language disorders

JCPP Advances, EarlyView.
Abstract Background Taxometric analysis is designed to test whether the latent structure underlying clinical conditions is categorical (taxonic) or dimensional. Despite its relevance to ongoing debates on neurodevelopmental conditions, its application to this field remains limited.
Enrico Toffalini, Margherita Calderan, Riccardo Pagan, Valentina Tobia, Edmund Sonuga‐Barke   +4 more
wiley   +1 more source

Effects of polygenes, parent–child relationship and frustration on junior high school students' aggressive behaviors

PsyCh Journal
The effects of the interaction between polygenes and the parent–child relationship on junior high school students' aggressive behaviors were explored through the frameworks of gene‐endophenotype‐behavior and neurophysiological basis.
Minghao Zhang, Zhenli Jiang, Kedi Zhao, Yaohua Zhang, Min Xu, Xiaohui Xu   +5 more
doaj   +1 more source

Polygenic Risk Scores: Genomes to Risk Prediction

Clinical Chemistry, 2023
Tristan J Hayeck, George B Busby, Sung Chun, Anna C F Lewis, Megan C Roberts, Bjarni J Vilhjálmsson   +5 more
openaire   +3 more sources

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source