Results 131 to 140 of about 67,612 (348)

High loading of polygenic risk for ADHD in children with comorbid aggression [PDF]

, 2013
Objective: Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk.
Agha, SS, Anney, RJL, Asherson, P, Banaschewski, T, Barke, Edmund, Biederman, J, Buitelaar, J, Doyle, AE, Faraone, SV, Franke, B, Freitag, C, Hakonarson, H, Hamshere, ML, Holmans, P, Kent, L, Kuntsi, J, Lambregts-Rommelse, N, Langley, K, Lesch, KP, Martin, J, McGough, JJ, Medland, SE, Merwood, A, Meyer, J, Neale, BM, O'Donovan, MC, Oades, RD, Owen, MJ, Palmason, H, Reif, A, Renner, TJ, Ripke, S, Roeyers, Herbert, Romanos, J, Romanos, M, Rothenberger, A, Steinhausen, HC, Stergiakouli, E, Thapar, A, Vasquez, AA, Warnke, A, Williams, N   +41 more
core   +1 more source

Assessment of Maladaptive Exercise History Among Individuals With Eating Disorders: Validation of a Brief, Self‐Report Measure

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Maladaptive exercise is a common symptom of eating disorders (EDs). While several measures exist to assess current maladaptive exercise, there are no validated self‐report tools to assess maladaptive exercise history—an important symptom domain among individuals with lifetime EDs.
Katherine Schaumberg, Hunna J. Watson, Laura M. Thornton, Hannah L. Kennedy, Shu H. Ong, Preston Roche, Kayla Costello, Wesley R. Barnhart, Sian B. Pauley‐Gadd, Rachael E. Flatt, Andreas Birgegård, Lisa Dinkler, Afrouz Abbaspour, Emma Forsén Mantilla, Elin Monell, Emma M. Frans, Sarah Barakat, Michaela A. Pettie, Richard Parker, Sarah Maguire, Jennifer Jordan, Martin A. Kennedy, Nailah Adams Morancie, Cynthia M. Bulik   +23 more
wiley   +1 more source

The Population Genetic Signature of Polygenic Local Adaptation

, 2014
Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals.
Berg, Jeremy J., Coop, Graham
core   +3 more sources

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Toward a Typology of Patients With Head and Neck Cancer: Biopsychosocial Profiles Predicting Longitudinal Quality of Life

Head &Neck, EarlyView.
ABSTRACT Background Quality of life (QoL) in head and neck cancer (HNC) is influenced by complex biopsychosocial factors, yet few longitudinal studies have examined these relationships immediately post‐treatment. Methods In this prospective study, 232 patients newly diagnosed with primary HNC completed psychometric assessments, clinical interviews, and
Haley Deamond, Cyril Devault‐Tousignant, Jacob Lang, Christopher Lo, Jennifer Silver, Nader Sadeghi, Zeev Rosberger, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Gabrielle Chartier, Marco Mascarella, Khalil Sultanem, Georges Shenouda, Fabio Cury, Melissa Henry   +18 more
wiley   +1 more source

Stacked neural network for predicting polygenic risk score

Scientific Reports
In recent years, the utility of polygenic risk scores (PRS) in forecasting disease susceptibility from genome-wide association studies (GWAS) results has been widely recognised.
Sun bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee   +4 more
doaj   +1 more source

Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder

Psychiatry Research Communications
Sleep problems are common in individuals with ADHD; however, the exact underlying mechanism is unknown. I Data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (N = 27,076), the Taiwan Biobank (N = 2373) and the Hamamatsu ...
Nagahide Takahashi, Tomoko Nishimura, Akemi Okumura, Taeko Harada, Toshiki Iwabuchi, Md Shafiur Rahman, Pi-Hua Liu, Gwo-Tsann Chuang, Yi-Cheng Chang, Yoko Nomura, Kenji J. Tsuchiya   +10 more
doaj   +1 more source

The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information

NeuroImage: Clinical, 2016
Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD).
Danai Dima, Simone de Jong, Gerome Breen, Sophia Frangou   +3 more
doaj   +1 more source

Polygenic risk scores: An overview from bench to bedside for personalised medicine [PDF]

, 2022
Benjamin Cross, Richard Turner, Munir Pirmohamed   +2 more
openalex   +1 more source

Genome-wide association study identifies 30 loci associated with bipolar disorder. [PDF]

, 2019
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional
Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Boks, Marco P, Boocock, James, Breen, Gerome, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Byrne, Enda M, Bækvad-Hansen, Marie, Bøen, Erlend, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coleman, Jonathan RI, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, de Leeuw, Christiaan A, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forstner, Andreas J, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Gaspar, Héléna A, Giambartolomei, Claudia, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Mattheisen, Manuel, McQuillin, Andrew, Pavlides, Jennifer M Whitehead, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pers, Tune H, Richards, Alexander L, Ripke, Stephan, Stahl, Eli A, Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng   +99 more
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