Results 141 to 150 of about 31,405 (257)

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes. [PDF]

Diabetologia
Jumentier B, Qu HQ, Lu T, Liu K, Kleinbrink EL, Klein K, Belbellaj W, Gamache I, Ferrat L, Butler-Laporte G, Li Y, Hakonarson H, Wu W, Polychronakos C, Greenwood CMT, Manousaki D.   +15 more
europepmc   +1 more source

Clinical implementation of polygenic risk scores

European Journal of Human Genetics
E. Roberts, N. Flaum, D. G. Evans
openaire   +3 more sources

PREDICT‐PD: A Two‐Stage Approach to Early Identification of Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Sasivimol Virameteekul, Sheena Waters, Brook Huxford, Ashvin Kuri, Manuela Tan, Laura Pérez‐Carbonell, Eduardo de Pablo‐Fernández, Anette Schrag, Alastair J. Noyce, Cristina Simonet   +9 more
wiley   +1 more source

Experimental dissection of phenotypic variation for quantitative disease resistance in canola (Brassica napus) – Leptosphaeria maculans interactions

Pest Management Science, EarlyView.
This graphical abstract illustrates how quantitative resistance to Leptosphaeria maculans in canola is experimentally estimated through multi‐environment replicated trials measuring crown canker severity. Genotype, environment and pathogen sources feed into phenotyping, followed by variance partitioning using mixed models and beta regression to ...
Luke G Barrett, Mohamed CM Zakeel, Angela P Van der Wouw, Rebecca Maher, Kurt D Lindbeck, Susan J Sprague   +5 more
wiley   +1 more source

GenoEye: A machine learning‐based framework for the prediction of intermediate eye color phenotypes

Journal of Forensic Sciences, EarlyView.
Abstract Forensic DNA phenotyping (FDP) enables the prediction of externally visible characteristics from genetic data, providing valuable investigative leads. While current approaches achieve high accuracy for blue and brown eye color, the prediction of intermediate phenotypes such as green and hazel remains challenging, particularly in Southern ...
Davide Dalfovo, Giorgia Pallafacchina, Gianluca Occhi, Alberto Marino, Giovanni Vazza, Christian Faccinetto, Alessandro Romanel   +6 more
wiley   +1 more source

Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer. [PDF]

JNCI Cancer Spectr
Klinkhammer H, Spier I, Perne C, Hoffmann P, Büttner R, Schröck E, Redler S, Jahn A, Franke M, Möslein G, Kloor M, Schmidt B, Vangala D, Nguyen HP, Forstner AJ, Steinke-Lange V, Holinski-Feder E, Hüneburg R, Maj C, Engel C, Mayr A, Aretz S.   +21 more
europepmc   +1 more source

Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Suicidal behaviors are complex phenotypes, often studied in the context of psychiatric comorbidities. However, little is known about the specific roles of psychiatric disorders and the etiology of suicidal behaviors that occur outside the context of psychiatric comorbidities.
Séverine Lannoy, Henrik Ohlsson, Mallory Stephenson, Jan Sundquist, Kristina Sundquist, Kenneth S. Kendler, Alexis C. Edwards   +6 more
wiley   +1 more source

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting. [PDF]

Hum Psychopharmacol
Heald A, Illangasekera Y, Loureiro CM, Shakespeare M, Jameson A, Phillipson A, Reynolds GP, Dalton C.   +7 more
europepmc   +1 more source

Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Hannah Buchbauer, Mazda Adli, Peter Schlattmann, Maximilian Berger, Tom Bschor, Thomas Stamm, Joachim Behr, Roland Ricken, Pichit Buspavanich   +8 more
wiley   +1 more source

Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction. [PDF]

Sci Rep
Naderi E, Watt GP, Knight JA, Malone KE, Lynch CF, John EM, Shu X, Nguyen TL, Oh JH, Woods M, Liang X, Derkach A, Pike MC, Bernstein JL.   +13 more
europepmc   +1 more source