Results 161 to 170 of about 7,071,839 (288)

Polygenic Risk Scores in Familial Hypercholesterolemia

Journal of the American College of Cardiology, 2019
Daniel J, Rader, Samip, Sheth
openaire   +2 more sources

Inheritance and stability of Cry2Ab2 resistance in an Ostrinia nubilalis strain originating from Wisconsin, U.S.

Pest Management Science, EarlyView.
Resistance to Cry2Ab2 protein in Ostrinia nubilalis is autosomal, functionally recessive, controlled by a single gene, and remains stable over 17 generations in the absence of Cry2Ab2 selection pressure. Abstract BACKGROUND Transgenic corn expressing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt), including Cry1Ab, Cry1Fa and/or ...
Tatum Dwyer, Yucheng Wang, Graham P. Head, Fei Yang   +3 more
wiley   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Cost-Effectiveness of Polygenic Risk Score-Guided Statin Therapy for Cardiovascular Disease Prevention in Singapore. [PDF]

JACC Asia
Ooi ILP, Chia AW, Chee YJ, Goh LL, Leong KP, Acharyya S, Dalan R, Saxena A.   +7 more
europepmc   +1 more source

Screening of Brazilian Isolated Yeasts Reveals Multiple Potential Chassis for Industrial Biotechnology

Yeast, EarlyView.
Harnessing Brazilian microbial diversity, comprehensive phenotypic screening of 79 yeast isolates identified non‐conventional strains with superior multi‐stress tolerance and metabolic versatility compared to S. cerevisiae under industrially relevant conditions.
Giovanna R. Maklouf, Lara I. S. Sousa, Juliana Pimentel Galhardo, Cecilia Trivellin, João Pedro R. Prado, Tássia Cristina da Silva, Ana C. S. R. de Carvalho, Juliana José, Gonçalo A. G. Pereira, Marcelo F. Carazzolle, Fellipe S. B. de Mello   +10 more
wiley   +1 more source

Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma. [PDF]

Transl Vis Sci Technol
Kai JY, Gong SY, Hu YH, Dong XX, Li DL, Ke C, Pan CW.   +6 more
europepmc   +1 more source

Clinical implementation of polygenic risk scores

European Journal of Human Genetics
E. Roberts, N. Flaum, D. G. Evans
openaire   +3 more sources

Future Challenges and Opportunities for the Viability of Animal Populations in Zoos and Aquariums

Zoo Biology, EarlyView.
ABSTRACT Maintaining sustainable animal populations is fundamental to zoo and aquarium missions in education, visitor engagement, entertainment, scientific advancement, public health and wellbeing, advocacy, and conservation impact. Yet, sustaining viable populations remains a persistent challenge.
Lisa J. Faust, John E. Andrews, Alex Ball, Rebecca Biddle, Rachel A. Bladow, Asako Y. Chaille, Marie Corlay, Veronica Cowl, Caitlin Curry, Candice Dorsey, J. Andrew DeWoody, Adam Eyres, Gina M. Ferrie, Elmar Fienieg, Ashley D. Franklin, Emily K. Latch, Andrea Putnam, Kristine Schad Eebes, Leah J. Williams   +18 more
wiley   +1 more source

Genetic Testing in Movement Disorders: Riding the Wave Without Being Swept Under

Movement Disorders, EarlyView.
Alessio Di Fonzo, Francesca Magrinelli
wiley   +1 more source

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source