Results 161 to 170 of about 67,612 (348)

Evaluation of Phenotyping Errors on Polygenic Risk Score Predictions

, 2020
Ruowang Li, Jiayi Tong, Rui Duan, Yong Chen, Jason H. Moore   +4 more
openalex   +1 more source

Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics [PDF]

, 2023
Ali Al‐Janabi, Stephen Eyre, Amy Foulkes, Adnan R. Khan, Nick Dand, Ekaterina Burova, Bernadette DeSilva, Areti Makrygeorgou, Emily Davies, Catherine Smith, C.E.M. Griffiths, Andrew P. Morris, Richard B. Warren   +12 more
openalex   +1 more source

Polygenic Risk Scores: Genomes to Risk Prediction

Clinical Chemistry, 2023
Tristan J Hayeck, George B Busby, Sung Chun, Anna C F Lewis, Megan C Roberts, Bjarni J Vilhjálmsson   +5 more
openaire   +3 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease [PDF]

, 2023
Aaron W. Aday, Minoo Bagheri, Nataraja Sarma Vaitinadin, Jonathan D. Mosley, Thomas J. Wang   +4 more
openalex   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

BMC Research Notes
Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide ...
Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard   +6 more
doaj   +1 more source

Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse [PDF]

, 2023
Mehdi Momen, K. Brauer, Margaret M. Patterson, Susannah J. Sample, Emily E. Binversie, Brian W. Davis, E. Gus Cothran, Guilherme J. M. Rosa, Sabrina H. Brounts, Peter Muir   +9 more
openalex   +1 more source

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

Interdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun, Lu Zhang, Xinyu Yao, Yunfei Liu, Xin Li, Feng Wen, Yong Dai, Ye Dai, Ziyu Du, Dijie Qiao, Ziwei Meng, Cong Hu, Chun Yan, Wei Chi   +13 more
wiley   +1 more source

The many roads to psychosis: recent advances in understanding risk and mechanisms. [PDF]

, 2018
Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder.
Bearden, Carrie E, Forsyth, Jennifer K
core