Results 171 to 180 of about 7,071,839 (288)

Joint associations of recovery capital and polygenic risk with electronic health record observed remission and relapse in substance use disorder: Longitudinal evidence from the All of Us research program

Addiction, EarlyView.
Abstract Background and aims Recovery capital and genetic liability may be related to substance use disorder (SUD) remission through psychosocial and biologic pathways, but their joint association with remission course remains poorly understood. This question is clinically important because people entering remission differ in recovery resources and ...
Janaka V. Kosgolla, Douglas C. Smith
wiley   +1 more source

Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer. [PDF]

Nat Commun
Zhang Y, Dai J, Gu P, Zhao Y, Christiani DC, Chen F, Shen S.   +6 more
europepmc   +1 more source

Polygenic prediction of cannabis‐related outcomes: Evidence from the Avon Longitudinal Study of Parents and Children longitudinal cohort and the European gene–environment interaction case–control study

Addiction, EarlyView.
Abstract Background and aims Polygenic risk scores (PRSs) for cannabis use disorder (CUD), major depressive disorder (MDD), insomnia and chronic pain, and early age at cannabis initiation might be linked to problematic cannabis use. We tested whether: (1) higher PRS for CUD, MDD, insomnia and chronic pain are associated with earlier initiation and ...
Edoardo Spinazzola, Isabelle Austin‐Zimmerman, Giulia Trotta, Zhikun Li, Perry B. M. Leung, Edward Chesney, Qiang Li, Luis Alameda, Celso Arango, Michael O'Donovan, Jim van Os, Pak C. Sham, Craig Morgan, Evangelos Vassos, Diego Quattrone, Tom Freeman, Marta Di Forti, Robin M. Murray   +17 more
wiley   +1 more source

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis – Application in a Real-World Setting [PDF]

BJPsych Open
Illangasekera Y, Loureiro C, Shakespeare M, Jameson A.   +3 more
europepmc   +2 more sources

A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations. [PDF]

Nat Genet
Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush WS, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GD, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA.   +41 more
europepmc   +1 more source

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

Polygenic Risk Score for Adult Idiopathic Hydrocele Testis: Susceptibility and Severity in a Japanese Cohort. [PDF]

Int J Mol Sci
Hattori-Kato M, Okuno Y, Honda S, Nomiya A, Zaitsu M, Takeuchi T.   +5 more
europepmc   +1 more source

Schizophrenia polygenic risk score and psychotic risk detection [PDF]

The Lancet Psychiatry, 2017
Poletti, Michele, Gebhardt, Eva, Raballo, Andrea   +2 more
openaire   +3 more sources

Early Life Neurodevelopmental Indicators of Attention‐Deficit/Hyperactivity Disorder at Age 10: A Prospective Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder associated with long‐term adverse outcomes, yet diagnosis often occurs years after symptoms first emerge. Because ADHD involves impairments across multiple developmental domains, early deviations in language, cognition, motor development and ...
Camilla Grube, María Hernández‐Lorca, Julie Rosenberg, Kristina Aagaard, Michael Widdowson, Tingting Wang, Nilo Vahman, Hanne Lunn Nissen, Jens Richardt Møllegaard Jepsen, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes, Rebecca K. Vinding   +12 more
wiley   +1 more source

The psychosocial impact of receiving a polygenic risk score informing risk of prostate cancer. [PDF]

Hered Cancer Clin Pract
Hogben M, Hainsworth E, Benton B, McHugh J, Myhill K, McGrowder E, Rageevakumar R, James D, Benafif S, Page EC, Eeles RA, Rowland E, Bancroft EK.   +12 more
europepmc   +1 more source