Results 151 to 160 of about 31,405 (257)

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

Leukocyte Telomere Length and Its Polygenic Risk Score in Post-Stroke Cognitive Impairment: Evidence From a Multicenter Cohort Study. [PDF]

Brain Behav
Zhao K, Shi Y, Yan H, Zhou H, Li J, Cheng S, Xu Z, Pan Y, Li Z, Meng X, Li H, Liao X, Jing J, Wang Y.   +13 more
europepmc   +1 more source

Schizophrenia polygenic risk score and psychotic risk detection [PDF]

The Lancet Psychiatry, 2017
Michele, Poletti, Eva, Gebhardt, Andrea, Raballo   +2 more
openaire   +2 more sources

Early Life Neurodevelopmental Indicators of Attention‐Deficit/Hyperactivity Disorder at Age 10: A Prospective Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder associated with long‐term adverse outcomes, yet diagnosis often occurs years after symptoms first emerge. Because ADHD involves impairments across multiple developmental domains, early deviations in language, cognition, motor development and ...
Camilla Grube, María Hernández‐Lorca, Julie Rosenberg, Kristina Aagaard, Michael Widdowson, Tingting Wang, Nilo Vahman, Hanne Lunn Nissen, Jens Richardt Møllegaard Jepsen, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes, Rebecca K. Vinding   +12 more
wiley   +1 more source

Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction. [PDF]

Front Chem
Liu Q, Shen H, Dang X, He MZ, Wei Y, Shi Y, Wei X, Chen F, Han D, Liu C, Hu J, Liu W.   +11 more
europepmc   +1 more source

“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Bioethics, EarlyView.
ABSTRACT After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post‐war population geneticists sought to establish rhetorical distance from the Nazi's state‐led campaigns, without abandoning their belief that actively shaping the population's genetics would produce a prosperous society.
Christopher R. Donohue, Ian A. Myles
wiley   +1 more source

Association of a polygenic risk score with low trauma fractures in people with HIV - The swiss HIV cohort study. [PDF]

PLoS One
Strickler C, Thorball CW, Schoepf IC, Schwenke J, Hasse B, Ryom L, Thurnheer MC, Fux C, Kahlert CR, Bernasconi E, Calmy A, Lamy O, Günthard HF, Ledergerber B, Fellay J, Tarr PE, Swiss HIV Cohort Study.   +16 more
europepmc   +1 more source

Information Discrimination and Its Implications on Distributing Healthcare Costs Fairly

Bioethics, EarlyView.
ABSTRACT When healthcare resources are scarce, they ought to be distributed fairly across society. For some theories of distribution, an assessment of individual health risk is required for a fair distribution of both healthcare resources and burdens. Despite this requirement, prevailing theories underappreciate the cost of information on health risk ...
Harisan U. Nasir
wiley   +1 more source

Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response. [PDF]

Front Genet
Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.   +4 more
europepmc   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, EarlyView.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source