Results 201 to 210 of about 65,839 (347)

Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones

, 2017
Yiwey Shieh, Donglei Hu, Lin Ma, Scott Huntsman, Charlotte C. Gard, Jessica W. T. Leung, Jeffrey A. Tice, Elad Ziv, Karla Kerlikowske, Steven R. Cummings   +9 more
openalex   +2 more sources

Combination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: A case –control study [PDF]

, 2020
Juan Carlos Triviño, A Ceba, E Rubio-Solsona, D. Serra, I Sanchez-Guiu, G Ribas, R Rosa, Mariona Cabo, L Bernad, Guillermo Pita, A Gonzalez-Neira, Garikoitz Legarda, JL Diaz, A García-Vigara, A Martínez-Aspas, M Escrig, B Bermejo, P Eroles, J Ibáñez, D. Salas, Ana Julve, Aitana Cano, A Lluch, Rebeca Miñambres, Javier Benı́tez   +24 more
openalex   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score [PDF]

Dayoon Kwon, Kimberly C. Paul, Cynthia Kusters, Jun Wu, Jeff M. Bronstein, Christina M. Lill, Matthias Ketzel, Ole Raachou-Nielsen, Johnni Hansen, Beate Ritz   +9 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Meta Polygenic Risk Score and Lung Cancer Risk Prediction: Two Prospective Cohort Studies

Zhimin Ma, Zhaopeng Zhu, Guanlian Pang, Jiaxin Gao, Wenjing Ge, Guoqing Wang, Mingxuan Zhu, Linnan Gong, Qiao Li, Ji Chen, Yating Fu, Chen Jin, Hongxia Ma, Meng Zhu, Hongbing Shen   +14 more
openalex   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Recommendations for responsible use of population descriptors in polygenic risk score development. [PDF]

Nat Genet
Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR, Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL, Polygenic Risk Methods Development (PRIMED) Consortium, Sun Q.   +26 more
europepmc   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, EarlyView.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

Sparse polygenic risk score inference with the spike-and-slab LASSO. [PDF]

Bioinformatics
Song J, Zabad S, Yang A, Gravel S, Li Y.
europepmc   +1 more source