Results 221 to 230 of about 67,612 (348)

Recommendations for responsible use of population descriptors in polygenic risk score development. [PDF]

Nat Genet
Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR, Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL, Polygenic Risk Methods Development (PRIMED) Consortium, Sun Q.   +26 more
europepmc   +1 more source

Meta Polygenic Risk Score and Lung Cancer Risk Prediction: Two Prospective Cohort Studies

Zhimin Ma, Zhaopeng Zhu, Guanlian Pang, Jiaxin Gao, Wenjing Ge, Guoqing Wang, Mingxuan Zhu, Linnan Gong, Qiao Li, Ji Chen, Yating Fu, Chen Jin, Hongxia Ma, Meng Zhu, Hongbing Shen   +14 more
openalex   +1 more source

“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Bioethics, EarlyView.
ABSTRACT After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post‐war population geneticists sought to establish rhetorical distance from the Nazi's state‐led campaigns, without abandoning their belief that actively shaping the population's genetics would produce a prosperous society.
Christopher R. Donohue, Ian A. Myles
wiley   +1 more source

Evaluating Individual Level Performance of Polygenic Risk Scores Using Early Onset High Genetic Risk Coronary Artery Disease as a Benchmark - Synthetic Data

Antony Tan
openalex   +1 more source

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia [PDF]

, 2017
Cloninger, C. Robert, et al,, Svrakic, Dragan M   +2 more
core   +1 more source

Information Discrimination and Its Implications on Distributing Healthcare Costs Fairly

Bioethics, EarlyView.
ABSTRACT When healthcare resources are scarce, they ought to be distributed fairly across society. For some theories of distribution, an assessment of individual health risk is required for a fair distribution of both healthcare resources and burdens. Despite this requirement, prevailing theories underappreciate the cost of information on health risk ...
Harisan U. Nasir
wiley   +1 more source

Polygenic risk score (PRS) as prostate cancer screening: ready for primetime? [PDF]

Ann Transl Med
Park J, Aragon-Ching JB.
europepmc   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Case Report: A combination of <i>CHEK2</i> and high polygenic risk score leads to early-onset male breast cancer. [PDF]

Front Oncol
Tamindarov K, Frank M, Wegscheider S, Benedix B, Lingscheidt T, Neukirchner K, Shamma H, Schnabel J, Tolkmitt M, Pillau K, Strehlow V, Hentschel J, Le Duc D.   +12 more
europepmc   +1 more source

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

, 2019
Tom G. Richardson, Sean Harrison, Gibran Hemani, George Davey Smith   +3 more
openalex   +1 more source