Results 241 to 250 of about 67,612 (348)

A review of methods and software for polygenic risk score analysis. [PDF]

PeerJ Comput Sci
Benoumhani S, Al-Wabil A, Imam N, Alfawaz B, Zubairi A, Aldossary D, AlEissa M.   +6 more
europepmc   +1 more source

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Polygenic risk scores and Parkinson’s disease in South Africa: Moving towards ancestry-informed disease prediction [PDF]

Kathryn Step, Carene Anne Alene Ndong Sima, Spencer Grant, Jonggeol Jeffrey Kim, Emily Waldo, Soraya Bardien, Ignácio F. Mata   +6 more
openalex   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Systemic inflammation, polygenic risk score, and risk of incident abdominal aortic aneurysm in the UK biobank. [PDF]

BMC Public Health
Pu H, Qiu P, Guo H, Lei J, Liu Y, Wei W, Hu J, Qin J, Wang R, Ye K, Xu Z, Wu Z, Lu X, Zhou Z.   +13 more
europepmc   +1 more source

Selective IL‐23 Inhibition in Conventional Treatment‐Refractory Pyoderma Gangrenosum: A Multicenter, Retrospective Study

International Journal of Dermatology, EarlyView.
The clinical effects of selective IL‐23 inhibition in refractory pyoderma gangrenosum, highlighting progressive ulcer healing, reduction in inflammation and pain, and steroid‐sparing effect, supporting the role of the IL‐23/Th17 axis as a therapeutic target.
Luca Bettolini, Carlo Alberto Maronese, Federica Derlino, Giovanni Genovese, Chiara Moltrasio, Luisa Sarno, Stefano Buffon, Bianca Cei, Giammarco Granieri, Valentina Dini, Marco Romanelli, Vincenzo Maione, Stefano Bighetti, Marina Venturini, Edoardo Cammarata, Paola Savoia, Antonio Di Guardo, Luigi Gargiulo, Ruggero Cascio Ingurgio, Antonio Costanzo, Lorenza Burzi, Claudia Leporati, Nunzia Di Cristo, Nicola Zerbinati, Alex G. Ortega‐Loayza, Angelo Valerio Marzano   +25 more
wiley   +1 more source

A machine learning-derived polygenic risk score reveals that healthy lifestyle counteracts obesity-related mortality. [PDF]

NPJ Digit Med
Xiao L, Liang S, Zeng L, Cai S, Wang J, Hong C, Li Y, Li R, Jiang P, Xie Z, Li T, Wu S, Liu L, Wu G, Lai W.   +14 more
europepmc   +1 more source

Supplementary Figure S4 from Development of a breast cancer risk prediction model incorporating polygenic risk scores and non-genetic risk factors for Korean women

Jihye Choi, Tae-Woong Ha, Hye‐Mi Choi, Han‐Byoel Lee, Hee-Chul Shin, Woosung Chung, Wonshik Han   +6 more
openalex   +1 more source

Polygenic Risk Scores in Clinical Schizophrenia Research [PDF]

American Journal of Psychiatry, 2019
openaire   +2 more sources

Genetic Determinants of Peanut‐Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study

Immunology, EarlyView.
A cumulative genetic score based on IgG4‐associated variants explains a substantial proportion of variance in psIgG4 levels during sustained peanut consumption, highlighting strong gene‐by‐environment interactions. Our findings suggest that early, sustained peanut consumption, in combination with genetic factors, promotes a protective immune response ...
Kanika Kanchan, Karen Cerosaletti, James A. Perry, George DuToit, Monali Manohar, Hua Ling, Justin E. Paschall, Srinath Sanda, R. Sharon Chinthrajah, Gerald T. Nepom, Kari C. Nadeau, Stacie M. Jones, Gideon Lack, Ingo Ruczinski, Rasika A. Mathias   +14 more
wiley   +1 more source