Results 91 to 100 of about 3,197,012 (359)

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release

PLoS ONE
We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals in UKB, using a unified pipeline for PRS evaluation.
Deborah J Thompson, Daniel Wells, Saskia Selzam, Iliana Peneva, Rachel Moore, Kevin Sharp, William A. Tarran, Edward J. Beard, Fernando Riveros-Mckay, Carla Giner-Delgado, Duncan Palmer, Priyanka Seth, James Harrison, M. Futema, Gil McVean, Vincent Plagnol, Peter Donnelly, Michael E Weale   +17 more
semanticscholar   +1 more source

Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs. [PDF]

, 2010
BackgroundIdiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and ...
Belanger, Janelle M, Famula, Thomas R, Grossman, Deborah I, Oberbauer, Anita M, Regan, Kelly R   +4 more
core   +3 more sources

Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. [PDF]

, 2020
Background and aimsThe associations between low educational attainment and substance use disorders (SUDs) may be related to a common genetic vulnerability.
Agrawal, Arpana, Aliev, Fazil, Almasy, Laura, Barr, Peter B, Bierut, Laura, Bucholz, Kathleen, Chan, Grace, Dick, Danielle M, Edenberg, Howard J, Johnson, Emma C, Kuo, Sally I-Chun, McCutcheon, Vivia V, Meyers, Jacquelyn L, Salvatore, Jessica E, Schuckit, Marc, Stephenson, Mallory, Su, Jinni, Tischfield, Jay, Wetherill, Leah   +18 more
core   +2 more sources

Estimation of Parental Effects Using Polygenic Scores [PDF]

Behavior Genetics, 2020
Abstract Offspring resemble their parents for both genetic and environmental reasons. Understanding the relative magnitude of these alternatives has long been a core interest in behavioral genetics research, but traditional designs, which compare phenotypic covariances to make inferences about unmeasured genetic and environmental ...
Jared Balbona, Yongkang Kim, Matthew C. Keller   +2 more
openaire   +3 more sources

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Nature Communications, 2020
Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis.
Davide Marnetto, Katri Pärna, Kristi Läll, Ludovica Molinaro, F. Montinaro, T. Haller, M. Metspalu, R. Mägi, K. Fischer, Luca Pagani   +9 more
semanticscholar   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]

, 2019
Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Tourette Association of America International Consortium for Genetics, Tourette International Collaborative Genetics Study, Woods, Douglas W.   +4 more
core   +1 more source

Metrics for Evaluating Polygenic Risk Scores [PDF]

JNCI Cancer Spectrum, 2020
Abstract There is growing interest in the use of polygenic risk scores based on genetic variants to predict cancer incidence. The type of metric used to evaluate the predictive performance of polygenic risk scores plays a crucial role in their interpretation.
openaire   +2 more sources