Results 91 to 100 of about 2,929,620 (353)

Prospects for using risk scores in polygenic medicine [PDF]

Genome Medicine, 2017
Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric ...
Lewis, Cathryn M., Vassos, Evangelos
openaire   +7 more sources

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

The nature of psychopathology

JCPP Advances, Volume 2, Issue 4, December 2022., 2022
Abstract Readers of JCPP Advances known that the dominant classification system (Diagnostic and Statistical Manual of Mental Disorders) in psychiatry and psychology conceptualizes psychopathology as discrete diagnostic categories. This measurement model builds on a strong assumption of a clear discontinuity between individuals who meet criteria for a ...
Henrik Larsson, Erik Pettersson
wiley   +1 more source

Incorporating External Risk Information with the Cox Model under Population Heterogeneity: Applications to Trans-Ancestry Polygenic Hazard Scores [PDF]

arXiv, 2023
Polygenic hazard score (PHS) models designed for European ancestry (EUR) individuals provide ample information regarding survival risk discrimination. Incorporating such information can improve the performance of risk discrimination in an internal small-sized non-EUR cohort.
arxiv  

Mutation spectrum and polygenic score in German patients with familial hypercholesterolemia

Clinical Genetics, 2020
Autosomal‐dominant familial hypercholesterolemia (FH) is characterized by increased plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) and a substantial risk to develop cardiovascular disease.
L. Rieck, F. Bardey, Thomas Grenkowitz, L. Bertram, J. Helmuth, C. Mischung, J. Spranger, E. Steinhagen-Thiessen, T. Bobbert, U. Kassner, I. Demuth   +10 more
semanticscholar   +1 more source

Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.

Brain : a journal of neurology, 2022
Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the central nervous system.
Hengameh Shams, Xiaorong Shao, A. Santaniello, G. Kirkish, A. Harroud, Qin Ma, N. Isobe, C. Schaefer, J. McCauley, B. Cree, Alessandro Didonna, S. Baranzini, N. Patsopoulos, S. Hauser, L. Barcellos, R. Henry, J. Oksenberg   +16 more
semanticscholar   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Clinical utility of polygenic scores for cardiometabolic disease in Arabs

Nature Communications, 2023
Arabs account for 5% of the world population and have a high burden of cardiometabolic disease, yet clinical utility of polygenic risk prediction in Arabs remains understudied. Among 5399 Arab patients, we optimize polygenic scores for 10 cardiometabolic
Injeong Shim, Hiroyuki Kuwahara, NingNing Chen, Mais O. Hashem, Lama AlAbdi, Mohamed Abouelhoda, Hong-Hee Won, Pradeep Natarajan, Patrick T. Ellinor, Amit V. Khera, Xin Gao, Fowzan S. Alkuraya, Akl C. Fahed   +12 more
doaj   +1 more source

A Bayesian method for estimating gene-level polygenicity under the framework of transcriptome-wide association study [PDF]

arXiv, 2022
Polygnicity refers to the phenomenon that multiple genetic variants have a non-zero effect on a complex trait. It is defined as the proportion of genetic variants that have a nonzero effect on the trait. Evaluation of polygenicity can provide valuable insights into the genetic architecture of the trait.
arxiv  

Applying polygenic risk scores to postpartum depression [PDF]

Archives of Women's Mental Health, 2014
The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis.
Dorret I. Boomsma, Grant W. Montgomery, Tania Carrillo-Roa, Tania Carrillo-Roa, Anjali K. Henders, Patrick F. Sullivan, Patrik K. E. Magnusson, Brett Chapman, Pamela A. F. Madden, Paul Lichtenstein, Gerard van Grootheest, Alexander Viktorin, Samantha Meltzer-Brody, Enda M. Byrne, Enda M. Byrne, Nicholas G. Martin, Hannah M Sallis, Brenda W.J.H. Penninx, George McMahon, Andrew C. Heath, Mikael Landén, Michele L. Pergadia, Lynn Boschloo, Debbie A Lawlor, David M. Evans, David M. Evans, Naomi R. Wray   +26 more
openaire   +6 more sources