Results 71 to 80 of about 1,650,847 (244)
Associations between the schizophrenia polygenic risk score and reports of childhood adversity.
, 2016 Associations between the schizophrenia polygenic risk score and reports of childhood adversity.
Helen L. Fisher (3129252) +10 more
core +1 more source
Maternal Factors Modifying the Link Between Genetic Risk for Autism and Developmental Milestones
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Although common genetic liability—quantified through polygenic risk scores (PRS)—accounts for substantial variance in autism spectrum disorder (ASD) liability, how prenatal environmental exposures interact with genetic predisposition to shape developmental outcomes remains poorly understood. Using the data from Autism Genetic Resource Exchange
Liliana D'Alesio +4 more
wiley +1 more source
Nature Communications, 2023 Polygenic risk scores are used to improve risk prediction for common diseases but typically have reduced accuracy for individuals of non-European ancestry.
Jiacheng Miao +5 more
doaj +1 more source
, 2019 Polygenic risk score for Alzheimer’s disease and trajectories of cardiometabolic risk factors in ...
Roxanna Korologou-linden
core +1 more source
Association Between Genetic Ancestry and Multiple Sclerosis Severity
Annals of Neurology, EarlyView.Objective The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). Methods Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyped from saliva using a commercial array. Genetic ancestry was inferred using
Benjamin M. Jacobs +32 more
wiley +1 more source
Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology
Annals of Neurology, EarlyView.Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko +8 more
wiley +1 more source
Number of affected individuals with high polygenic lipid score or Mendelian SNPs.
, 2016 Number of affected individuals with high polygenic lipid score or Mendelian SNPs.
Sanni Söderlund (844794) +16 more
core +1 more source
Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep
Animal Research and One Health, EarlyView.Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang +3 more
wiley +1 more source
Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis
Animal Research and One Health, EarlyView.Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li +10 more
wiley +1 more source
, 2021 Additional file 2: Revised polygenic score reports for coronary artery disease. A. Page one of ‘significantly increased risk’ report. B. Page one of ‘average risk’ report. C. Page one of ‘significantly decreased risk’ report. D.
Mary O’Reilly (11514337) +13 more
core +1 more source