Results 81 to 90 of about 1,650,847 (244)

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Variability of polygenic prediction for body mass index in Africa

Genome Medicine
Background Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent ...
Tinashe Chikowore, Kristi Läll, Lisa K. Micklesfield, Zane Lombard, Julia H. Goedecke, Segun Fatumo, Shane A. Norris, Reedik Magi, Michele Ramsay, Paul W. Franks, Guillaume Pare, Andrew P. Morris   +11 more
doaj   +1 more source

Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach

Chronic Diseases and Translational Medicine, EarlyView.
The Vital Conditions Framework. Graphical representation of the Vital Conditions for Health Framework with seven domains. Images used with permission from The Rippel Foundation: An Introduction to the Vital Conditions for Health and Well‐Being. https://rippel.org/events/webinar-an-introduction-to-the-vital-conditions-for-health-and-well-being/. Federal
Stephanie Kjelstrom, Richard Hass, Robert Vollbrecht, Brandon George, Sharon Larson   +4 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort

International Journal of Cardiology. Cardiovascular Risk and Prevention
Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.
Carlos Iribarren, Meng Lu, Martha Gulati, Nathan D. Wong, Roberto Elosua, Jamal S. Rana   +5 more
doaj   +1 more source

Autism Spectrum Disorder, Attention‐Deficit/Hyperactivity Disorder, Tic Disorder, and Obsessive‐Compulsive Disorder in Individuals With Eating Disorders and Their Siblings: A Nationwide Finnish Cohort Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Neurodevelopmental conditions frequently co‐occur with eating disorders (EDs). This study aimed to investigate the occurrence of attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), tic disorder (TD), and obsessive‐compulsive disorder (OCD) in individuals with EDs and their full and half siblings.
Emma Saure, Pyry N. Sipilä, Susanna Hinkka‐Yli‐Salomäki, Andre Sourander, Elina Santti, Anu Raevuori   +5 more
wiley   +1 more source

Distribution of hair loss by male pattern baldness polygenic score decile in the independent sample.

, 2017
Distribution of hair loss by male pattern baldness polygenic score decile in the independent sample.
Riccardo E. Marioni (111477), Catharine R. Gale (308293), Stuart J. Ritchie (329723), Saskia P. Hagenaars (2954106), Gail Davies (107670), David C. Liewald (496304), W. David Hill (534895), David J. Porteous (107720), Ian J. Deary (107724), Sarah E. Harris (107676)   +9 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Polygenic risk score translation across diverse populations

Frontiers in Cardiovascular Medicine
Polygenic risk scores (PRSs) are increasingly being considered as tools to refine risk stratification in cardiovascular and cardiometabolic disease, but their clinical translation remains constrained by a central limitation: most currently available PRSs
Jose E. Krieger
doaj   +1 more source

Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis

, 2022
A corrigendum on - Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score ...
Tiwari, Arun K., Breen, Gerome, Weissman, Myrna M., Awasthi, Swapnil, Marshe, Victoria S., Levinson, Doug F., Hamilton, Steve, Adams, Mark J., Jones, Lisa, Lewis, Cathryn M., Gonçalves, Vanessa F., Boomsma, Dorret I., Penninx, Brenda W. J. H., McIntosh, Andrew M., Ripke, Stephan, Martin, Nicholas G., Zai, Clement C., Baune, Bernhard T., Melhuish Beaupre, Lindsay M.   +18 more
core   +1 more source