Results 61 to 70 of about 1,650,847 (244)
Performance of polygenic scores for predicting phobic anxiety. [PDF]
PLoS ONE, 2013 Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization.
Stefan Walter +9 more
doaj +1 more source
, 2021 Additional file 2: Fig. S1 Ancestry PCA of HapMap and our samples. Fig. S2 Distribution of the polygenic risk score according to the different 7 risk groups by sex. Fig. S3 Distribution of the polygenic risk score according to the different 7 risk groups
Elisabet Guinó (90345) +14 more
core +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Little is known about how stigma is perceived within psychiatric genetics, a field increasingly central to public discussions about heredity, neurodiversity, and psychiatric risk. Understanding how stigma is perceived and experienced by psychiatric geneticists is important for guiding responsible communication and future stigma‐reduction ...
Anaïs B. Thijssen +14 more
wiley +1 more source
, 2023 Information on the 21 SNPs used in the definition of Hodgkin lymphoma associated polygenic risk score.
Han Zhang (110653) +6 more
core +1 more source
Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri +6 more
wiley +1 more source
The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle +3 more
wiley +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Psychobehavioral and physical health traits often co‐occur. Although previous studies have identified associations between neuroticism, psychological distress, insomnia, and inflammatory biomarkers such as C‐reactive protein (CRP), it remains unclear whether there is a genetic basis to these associations, and which biological pathways are ...
Lydia M Li +4 more
wiley +1 more source
Interpreting polygenic score effects in sibling analysis.
PLoS ONEResearchers often claim that sibling analysis can be used to separate causal genetic effects from the assortment of biases that contaminate most downstream genetic studies (e.g. polygenic score predictors).
Jason Fletcher +3 more
doaj +2 more sources
Assessment of genetic risk for improved clinical-neuropathological correlations
Acta Neuropathologica Communications, 2020 In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology.
Barbara E. Spencer +3 more
doaj +1 more source
GenoRisk: A polygenic risk score for Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson +10 more
doaj +1 more source