Results 141 to 150 of about 40,214 (287)

Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling

Nature Communications
Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated polygenic scores across 457 phenotypes using genotyping array data from China Medical University Hospital.
Ting-Hsuan Sun, Chia-Chun Wang, Ting-Yuan Liu, Shih-Chang Lo, Yi-Xuan Huang, Shang-Yu Chien, Yu-De Chu, Fuu-Jen Tsai, Kai-Cheng Hsu   +8 more
doaj   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

Development and Validation of Polygenic Scores for Retinal Vessel Calibers [PDF]

Chenglong Yu, Nuwanthi Rupasinghe, Liubov D. Robman, Lauren Hodgson, Thao Pham, Robyn L. Woods, Rory Wolfe, Stéphanie Ward, Walter P. Abhayaratna, Robyn H. Guymer, Catherine Robb, Peter Fransquet, Tian Lin, Xueling Sim, Sandra E. Staffieri, Stuart MacGregor, John J. McNeil, Paul Lacaze   +17 more
openalex   +1 more source

Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population [PDF]

, 2020
Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G. Orchard, Jane Tiller, Jessica E. Lockery, Robyn L. Woods, Rory Wolfe, Alan E. Renton, Alison Goate, Robert Sebra, Eric E. Schadt, Amy Brodtmann, Raj C. Shah, Elsdon Storey, Anne M. Murray, John J. McNeil, Paul Lacaze   +17 more
openalex   +1 more source

Polygenic Risk for Pre‐Eclampsia and the Long‐Term Risk of Incident Hypertension and Cardiovascular Disease: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate whether genetic predisposition to pre‐eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women. Design Prospective population‐based cohort study.
Eun‐Saem Choi, Sang‐Hyuk Jung, Young Mi Jung, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Jaeyoung Kim, Beomsu Kim, Chamlee Cho, Injeong Shim, Dokyoon Kim, Hong‐Hee Won, Seung Mi Lee   +12 more
wiley   +1 more source

Effect of polygenic scores on the relationship between psychosis and cognition

Translational Psychiatry
Cognitive impairment is an important but often under-researched symptom in psychosis. Both psychosis and cognition are highly heritable and there is evidence of a genetic effect on the relationship between them.
Lauren Varney, Krisztina Jedlovszky, Baihan Wang, Stephen Murtough, Marius Cotic, Alvin Richards-Belle, Noushin Saadullah Khani, Robin Lau, Rosemary Abidoph, Andrew McQuillin, Johan H. Thygesen, Psychosis Endophenotypes International Consortium (PEIC), Genetic Risk and Outcome of Psychosis (GROUP) Investigators, Behrooz Z. Alizadeh, Stephan Bender, Benedicto Crespo-Facorro, Jeremy Hall, Conrad Iyegbe, Eugenia Kravariti, Stephen M. Lawrie, Ignacio Mata, Colm McDonald, Robin M. Murray, Diana Prata, Timothea Toulopoulou, Neeltje EM van Haren, Elvira Bramon   +26 more
doaj   +1 more source

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight (GRSBW), derived from participants of predominantly European ancestry, within a diverse U.S.
Bita Tristani‐Firouzi, Lisa Pappas, Merry Joseph, Maryam Zeinomar, Michelle P. Debbink, Joseph Mims, Rafael Guerrero, Barry Moore, Robert M. Silver, Tsegaselassie Workalemahu, David Haas, Jonathan G. Steller, George Saade, Nathan R. Blue   +13 more
wiley   +1 more source

Development of a Polygenic Risk Score for BMI to Assess the Genetic Susceptibility to Obesity and Related Diseases in the Korean Population [PDF]

, 2023
Nara Yoon, Yoon Shin Cho
openalex   +1 more source

Complications Following Bilateral Salpingectomy by Indication: Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Assess the short‐term surgical outcomes of bilateral salpingectomy performed as a standalone procedure, focusing on complication rates by surgical indication and age group. Design Retrospective population‐based cohort. Setting British Columbia, Canada, from January 1st, 2008, to December 31st, 2022.
Alexandra Lukey, Helena Abreu do Valle, A. Fuchsia Howard, Celeste Leigh Pearce, David G. Huntsman, Janice S. Kwon, Jessica N. McAlpine, Michael R. Law, Paramdeep Kaur, Rafael Meza, Gillian E. Hanley   +10 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source