Results 181 to 190 of about 2,929,620 (353)

Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study

JCPP Advances, EarlyView.
This multicenter study demonstrated that siblings of children with higher YGTSS score showed a higher level of ASD symptoms. We further report that only female siblings of children with high tic symptom severity showed higher inattention and ODD symptoms.
Olga Sidiropoulou, Jennifer Glaus, Julie Hagstrøm, Setareh Ranjbar, Renata Rizzo, EMTICS collaborative group, Pieter J. Hoekstra, Andrea Dietrich, Kerstin J. Plessen   +8 more
wiley   +1 more source

Polygenic risk scores [PDF]

Journal of Advanced Nursing, 2019
openaire   +4 more sources

Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)

JCPP Advances, EarlyView.
Abstract Background Mothers' experience of adverse life events (ALEs, e.g., divorce, bereavement, injury) during pregnancy has been linked with neurodevelopmental conditions like autism, and related traits like social communication difficulties and repetitive behavior in children.
Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist   +10 more
wiley   +1 more source

Deep-learning prediction of cardiovascular outcomes from routine retinal images in individuals with type 2 diabetes

Cardiovascular Diabetology
Background Prior studies have demonstrated an association between retinal vascular features and cardiovascular disease (CVD), however most studies have only evaluated a few simple parameters at a time.
Mohammad Ghouse Syed, Emanuele Trucco, Muthu R. K. Mookiah, Chim C. Lang, Rory J. McCrimmon, Colin N. A. Palmer, Ewan R. Pearson, Alex S. F. Doney, Ify R. Mordi   +8 more
doaj   +1 more source

Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population

JCPP Advances, EarlyView.
Abstract Background Attention Deficit Hyperactivity Disorder (ADHD) is commonly defined as a categorical diagnosis requiring clinically severe symptoms and impact on functioning. However, ADHD and other neurodevelopmental traits are also distributed continuously in the general population, where their impact on functioning is less clear.
Louise Horstmann, Charlotte A. Dennison, Evie Stergiakouli, Kate Langley, Joanna Martin   +4 more
wiley   +1 more source

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains [PDF]

, 2017
Siri Ranlund, Stella Calafato, Johan H. Thygesen, Kuang Lin, Wiepke Cahn, Benedicto Crespo‐Facorro, Sonja M. C. de Zwarte, Álvaro Díez, Marta Di Forti, Conrad Iyegbe, Assen Jablensky, Rebecca Jones, Mei‐Hua Hall, René S. Kahn, Luba Kalaydjieva, Eugenia Kravariti, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Marco Picchioni, Diana Prata, Dan Rujescu, Katja Schulze, Madiha Shaikh, Timothea Toulopoulou, Neeltje E.M. van Haren, Jim van Os, Evangelos Vassos, Muriel Walshe, Cathryn M. Lewis, Robin M. Murray, John Powell, Elvira Bramon   +32 more
openalex   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort

International Journal of Cardiology. Cardiovascular Risk and Prevention
Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.
Carlos Iribarren, Meng Lu, Martha Gulati, Nathan D. Wong, Roberto Elosua, Jamal S. Rana   +5 more
doaj  

Stacked neural network for predicting polygenic risk score

Scientific Reports
In recent years, the utility of polygenic risk scores (PRS) in forecasting disease susceptibility from genome-wide association studies (GWAS) results has been widely recognised.
Sun bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee   +4 more
doaj   +1 more source

Genetic risk sum score comprised of common polygenic variation is associated with body mass index

, 2010
Roseann E. Peterson, Hermine H. Maes, Peter Holmans, Alan R. Sanders, Douglas F. Levinson, Jianxin Shi, Kenneth S. Kendler, Pablo V. Gejman, Bradley T. Webb   +8 more
openalex   +2 more sources