Results 11 to 20 of about 40,214 (287)
Polygenic Risk Score Prediction for Endometriosis [PDF]
Frontiers in Reproductive Health, 2021 Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen +15 more
doaj +8 more sources
Polygenic risk score prediction accuracy convergence [PDF]
HGG Advances, 2023 Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases.
Léo Henches +16 more
doaj +5 more sources
Communications BiologyPolygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung +6 more
doaj +3 more sources
Polygenic scores: prediction versus explanation [PDF]
Molecular Psychiatry, 2021 AbstractDuring the past decade, polygenic scores have become a fast-growing area of research in the behavioural sciences. The ability to directly assess people’s genetic propensities has transformed research by making it possible to add genetic predictors of traits to any study.
Robert Plomin, Sophie von Stumm
openaire +5 more sources
Philosophy of Medicine, 2023 This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects.
James Woodward, Kenneth Kendler
openaire +3 more sources
Nature Reviews Cancer, 2023 Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer have been identified. The relative risk associated with individual variants is small and of limited clinical significance.
Yang, Xin +3 more
openaire +2 more sources
Headaches and polygenic scores [PDF]
Neurology Genetics, 2019 Polygenic risk scores are en vogue. This ubiquitous statistic quantifies disease liability for an individual by aggregating risk contributions from a large number of genetic variants into a single score. Recent publications have argued that risk models currently used in clinical settings for coronary artery disease can be improved by including ...
Vilhjálmsson, Bjarni Jóhann +1 more
openaire +2 more sources
Polygenic scores and social science
Behavioral and Brain Sciences, 2023 Abstract It is a hotly contested issue whether polygenic scores should play a major role in the social sciences. Here, we defend a methodologically pluralist stance in which sociogenomics should abandon its hype and recognize that it suffers from all the methodological difficulties of the social sciences, yet nevertheless maintain an optimistic ...
Walter Veit, Heather Browning
openaire +4 more sources
Polygenic Risk Scores and Physical Activity [PDF]
Medicine & Science in Sports & Exercise, 2020 ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M. +13 more
openaire +6 more sources
Alzheimer’s Research & Therapy, 2023 Background Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to evaluate the impact of a polygenic score for general cognition on cognition decline rate, while considering baseline ...
Tingting Liu +10 more
doaj +1 more source