Results 11 to 20 of about 3,197,012 (359)

Performance of polygenic scores for predicting phobic anxiety. [PDF]

PLoS ONE, 2013
Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization.
Stefan Walter, M Maria Glymour, Karestan Koenen, Liming Liang, Eric J Tchetgen Tchetgen, Marilyn Cornelis, Shun-Chiao Chang, Eric Rimm, Ichiro Kawachi, Laura D Kubzansky   +9 more
doaj   +6 more sources

Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study. [PDF]

Anesthesiology
Background: Postoperative nausea and vomiting (PONV) is a key driver of unplanned admission and patient satisfaction after surgery. Because traditional risk factors do not completely explain variability in risk, this study hypothesized that genetics may ...
Douville NJ, Bastarache L, Bastarache L, He J, Wu KH, Vanderwerff B, Bertucci-Richter E, Hornsby WE, Lewis A, Jewell ES, Kheterpal S, Shah N, Mathis M, Engoren MC, Douville CB, Surakka I, Willer C, Kertai MD.   +17 more
europepmc   +2 more sources

Associations of perceived neighborhood factors and Alzheimer's disease polygenic score with cognition: Evidence from the Health and Retirement Study. [PDF]

PLoS ONE
BackgroundWe examined the relationships between neighborhood characteristics, cumulative genetic risk for Alzheimer's disease (polygenic scores for Alzheimer's disease), and cognitive function using data from the Health and Retirement Study (2008-2020 ...
Erin B Ware, Peiyao Zhu, Grace Noppert, Mingzhou Fu, Mikayla Benbow, Lindsay C Kobayashi, Lindsay H Ryan, Kelly M Bakulski   +7 more
doaj   +2 more sources

Polygenic score accuracy in ancient samples: Quantifying the effects of allelic turnover.

PLoS Genetics, 2022
Polygenic scores link the genotypes of ancient individuals to their phenotypes, which are often unobservable, offering a tantalizing opportunity to reconstruct complex trait evolution.
Maryn O Carlson, Daniel P Rice, Jeremy J Berg, Matthias Steinrücken   +3 more
doaj   +2 more sources

Risk factors affecting polygenic score performance across diverse cohorts. [PDF]

Elife, 2023
Hui D, Dudek S, Kiryluk K, Walunas TL, Kullo IJ, Wei WQ, Tiwari H, Peterson JF, Chung WK, Davis BH, Khan A, Kottyan LC, Limdi NA, Feng Q, Puckelwartz MJ, Weng C, Smith JL, Karlson EW, Regeneron Genetics Center, Penn Medicine BioBank, Jarvik GP, Ritchie MD.   +21 more
europepmc   +3 more sources

PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development [PDF]

PeerJ
The rapid development of next-generation sequencing technologies and genomic data sharing initiatives during the post-Human Genome Project-era has catalyzed major advances in individualized medicine research.
Tutku Yaraş, Yavuz Oktay, Gökhan Karakülah   +2 more
doaj   +3 more sources

PRSet: Pathway-based polygenic risk score analyses and software.

PLoS Genetics, 2023
Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications.
Shing Wan Choi, Judit García-González, Yunfeng Ruan, Hei Man Wu, Christian Porras, Jessica Johnson, Bipolar Disorder Working group of the Psychiatric Genomics Consortium, Clive J Hoggart, Paul F O'Reilly   +8 more
doaj   +2 more sources

Polygenic risk score prediction accuracy convergence [PDF]

HGG Advances, 2023
Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases.
Léo Henches, Jihye Kim, Zhiyu Yang, Simone Rubinacci, Gabriel Pires, Clara Albiñana, Christophe Boetto, Hanna Julienne, Arthur Frouin, Antoine Auvergne, Yuka Suzuki, Sarah Djebali, Olivier Delaneau, Andrea Ganna, Bjarni Vilhjálmsson, Florian Privé, Hugues Aschard   +16 more
doaj   +5 more sources

The Polygenic Score Catalog: new functionality and tools to enable FAIR research

medRxiv
Polygenic scores (PGS) have transformed human genetic research and have multiple potential clinical applications, including risk stratification for disease prevention and prediction of treatment response.
Lambert SA, Wingfield B, Gibson JT, Gil L, Ramachandran S, Yvon F, Saverimuttu S, Tinsley E, Lewis E, Ritchie SC, Wu J, Canovas R, McMahon A, Harris LW, Parkinson H, Inouye M.   +15 more
europepmc   +2 more sources

Polygenic scores: prediction versus explanation [PDF]

Molecular Psychiatry, 2021
AbstractDuring the past decade, polygenic scores have become a fast-growing area of research in the behavioural sciences. The ability to directly assess people’s genetic propensities has transformed research by making it possible to add genetic predictors of traits to any study.
Robert Plomin, Sophie von Stumm
openaire   +5 more sources