Results 11 to 20 of about 2,929,620 (353)

PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development [PDF]

PeerJ
The rapid development of next-generation sequencing technologies and genomic data sharing initiatives during the post-Human Genome Project-era has catalyzed major advances in individualized medicine research.
Tutku Yaraş, Yavuz Oktay, Gökhan Karakülah   +2 more
doaj   +3 more sources

Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes [PDF]

Diabetes Care, 2023
OBJECTIVE To assess whether increased genetic risk of type 2 diabetes (T2D) is associated with the development of hyperglycemia after glucocorticoid treatment.
A. Deutsch, Philip H. Schroeder, Ravi Mandla, Sarah Kang, F. Erenler, J. Mercader, M. Udler, J. Florez, L. Brenner   +8 more
semanticscholar   +2 more sources

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction

Communications Biology
Polygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung, Hae-Un Jung, Eun Ju Baek, Shin Young Kwon, Ji-One Kang, Ji Eun Lim, Bermseok Oh   +6 more
doaj   +3 more sources

A polygenic score method boosted by non-additive models [PDF]

Nature Communications
Dominance heritability in complex traits has received increasing recognition. However, most polygenic score (PGS) approaches do not incorporate non-additive effects.
Rikifumi Ohta, Yosuke Tanigawa, Yuta Suzuki, Manolis Kellis, Shinichi Morishita   +4 more
doaj   +2 more sources

Polygenic scores: prediction versus explanation [PDF]

Molecular Psychiatry, 2021
AbstractDuring the past decade, polygenic scores have become a fast-growing area of research in the behavioural sciences. The ability to directly assess people’s genetic propensities has transformed research by making it possible to add genetic predictors of traits to any study.
Robert Plomin, Sophie von Stumm
openaire   +4 more sources

Polygenic scores in cancer

Nature Reviews Cancer, 2023
Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer have been identified. The relative risk associated with individual variants is small and of limited clinical significance.
Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C, Pharoah, Paul DP   +3 more
openaire   +2 more sources

Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Molecular Psychiatry, 2023
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide.
Azmeraw T. Amare, A. Thalamuthu, K. Schubert, J. Fullerton, M. Ahmed, Simon Hartmann, S. Papiol, U. Heilbronner, F. Degenhardt, F. Tekola-Ayele, L. Hou, Y. Hsu, T. Shekhtman, M. Adli, N. Akula, K. Akiyama, R. Ardau, B. Arias, J. Aubry, R. Hasler, H. Richard-Lepouriel, N. Perroud, L. Backlund, A. Bhattacharjee, F. Bellivier, A. Benabarre, S. Bengesser, J. Biernacka, A. Birner, C. Marie-Claire, P. Cervantes, Hsi-Chung Chen, C. Chillotti, S. Cichon, C. Cruceanu, P. Czerski, N. Dalkner, M. Del Zompo, J. DePaulo, B. Étain, S. Jamain, P. Falkai, A. Forstner, L. Frisén, M. Frye, S. Gard, J. Garnham, F. Goes, M. Grigoroiu-Serbanescu, A. Fallgatter, Sophia Stegmaier, T. Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, K. Adorjan, M. Budde, M. Heilbronner, J. Kalman, M. O. Kohshour, D. Reich-Erkelenz, S. Schaupp, E. Schulte, F. Senner, T. Vogl, I. Anghelescu, V. Arolt, U. Dannlowski, D. Dietrich, C. Figge, M. Jäger, F. Lang, G. Juckel, C. Konrad, Jens-Peter Reimer, M. Schmauss, A. Schmitt, C. Spitzer, M. von Hagen, J. Wiltfang, J. Zimmermann, Till F. M. Andlauer, A. Fischer, F. Bermpohl, P. Ritter, S. Matura, A. Gryaznova, I. Falkenberg, Cüneyt Yildiz, T. Kircher, Julia Schmidt, Marius K. Koch, Kathrin Gade, S. Trost, I. Haussleiter, M. Lambert, A. Rohenkohl, Vivien Kraft, P. Grof, Ryota Hashimoto, J. Hauser, S. Herms, P. Hoffmann, E. Jiménez, J. Kahn, L. Kassem, Po-Hsiu Kuo, Tadafumi Kato, J. Kelsoe, S. Kittel-Schneider, E. Ferensztajn-Rochowiak, B. König, I. Kusumi, G. Laje, M. Landén, C. Lavebratt, M. Leboyer, S. Leckband, A. Tortorella, M. Manchia, Lina Martinsson, M. McCarthy, S. McElroy, F. Colom, V. Millischer, M. Mitjans, Francis M. Mondimore, P. Monteleone, C. Nievergelt, M. Nöthen, Tomáš Dvořáčková Blanka Novák, C. O’Donovan, Norio Ozaki, A. Pfennig, C. Pisanu, J. Potash, A. Reif, E. Reininghaus, G. Rouleau, J. Rybakowski, M. Schalling, P. Schofield, Barbara W. Schweizer, G. Severino, P. Shilling, Katzutaka Shimoda, C. Simhandl, C. Slaney, A. Squassina, T. Stamm, P. Stopková, M. Maj, G. Turecki, E. Vieta, J. Veeh, S. Witt, Adam Wright, P. Zandi, P. Mitchell, M. Bauer, M. Alda, M. Rietschel, F. McMahon, T. Schulze, S. Clark, B. Baune   +165 more
semanticscholar   +1 more source

Development of risk prediction models for depression combining genetic and early life risk factors

Frontiers in Neuroscience, 2023
BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu, Patrícia Pelufo Silveira, Patrícia Pelufo Silveira, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood   +6 more
doaj   +1 more source

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

Nature Network Boston, 2023
A polygenic risk score for coronary artery disease developed using data from individuals of five different ancestries has increased accuracy across diverse populations.
A. Patel, Minxian Wang, Y. Ruan, S. Koyama, S. Clarke, Xiong Yang, C. Tcheandjieu, Saaket Agrawal, A. Fahed, P. Ellinor, P. Tsao, Yan V. Sun, Kelly Cho, P. Wilson, T. Assimes, D. V. van Heel, A. Butterworth, Krishna G. Aragam, P. Natarajan, A. Khera   +19 more
semanticscholar   +1 more source

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease

Nature Genetics, 2021
A key driver of patients’ well-being and clinical trials for Parkinson’s disease (PD) is the course that the disease takes over time (progression and prognosis).
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, J. Locascio, J. Corvol, Frank Zhu, Xianjun Dong, J. Maple-Grødem, M. C. Campbell, A. Elbaz, S. Lesage, A. Brice, G. Mangone, J. Growdon, A. Hung, M. Schwarzschild, M. Hayes, A. Wills, T. Herrington, B. Ravina, I. Shoulson, P. Taba, S. Kõks, T. Beach, F. Cormier‐Dequaire, G. Alves, O. Tysnes, J. Perlmutter, P. Heutink, S. Amr, J. V. van Hilten, M. Kasten, B. Mollenhauer, C. Trenkwalder, C. Klein, R. Barker, C. Williams-Gray, J. Marinus, C. Scherzer   +38 more
semanticscholar   +1 more source