Results 31 to 40 of about 1,650,847 (244)
BMC Medical Genomics, 2020 Background Polygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well-established genomic locus (APOE), the ...
Erin B. Ware +3 more
doaj +1 more source
Box plot of the polygenic risk score in HCC progressors vs. non-progressors.
, 2023 Box plot of the polygenic risk score in HCC progressors vs. non-progressors.
Fasiha Kanwal (4737003) +14 more
core +1 more source
PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development [PDF]
PeerJThe rapid development of next-generation sequencing technologies and genomic data sharing initiatives during the post-Human Genome Project-era has catalyzed major advances in individualized medicine research.
Tutku Yaraş +2 more
doaj +2 more sources
Nature Communications, 2022 Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with ...
Nuzulul Kurniansyah +37 more
doaj +1 more source
Association of High Polygenic Score with Alzheimer’s Disease in the UK Biobank.
, 2022 Association of High Polygenic Score with Alzheimer’s Disease in the UK Biobank.
Robert Gerszten (12133141) +15 more
core +1 more source
Geographic Clustering of Polygenic Scores at Different Stages of the Life Course
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018 We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent’s state of birth with corresponding phenotypes. The polygenic scores for height and
Benjamin W. Domingue +3 more
doaj +1 more source
A multiple polygenic score approach for predicting breast cancer
, 2021 This project aims at applying a multiple polygenic score approach for predicting the risk of breast cancer of European ancestry females, exploring its efficacy, and investigating the genetic information carried by a series of phenotypic ...
Yuchen Ning, Philipp D. Koellinger
core +1 more source
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease
Translational Psychiatry, 2021 Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker +10 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source