Results 11 to 20 of about 1,650,847 (244)

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores [PDF]

Communications Biology, 2022
The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T. W. Ebbert, The Alzheimer’s Disease Neuroimaging Initiative, Justin B. Miller, John S. K. Kauwe   +8 more
doaj   +6 more sources

Polygenic risk score: use in migraine research [PDF]

The Journal of Headache and Pain, 2018
Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen   +3 more
doaj   +2 more sources

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations [PDF]

Nature Communications
Polygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations ...
Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika R. Iyer, Austin T. Hilliard, Jeffrey Haessler, Ran Tao, K. Alaine Broadaway, Yujie Wang, Nikita Pozdeyev, Frederik F. Stæger, Chaojie Yang, Brett Vanderwerff, Amit D. Patki, Lauren Stalbow, Meng Lin, Nicholas Rafaels, Jonathan Shortt, Laura Wiley, Maggie Stanislawski, Jack Pattee, Lea Davis, Peter S. Straub, Megan M. Shuey, Nancy J. Cox, Nanette R. Lee, Marit E. Jørgensen, Peter Bjerregaard, Christina Larsen, Torben Hansen, Ida Moltke, James B. Meigs, Daniel O. Stram, Xianyong Yin, Xiang Zhou, Kyong-Mi Chang, Shoa L. Clarke, Rodrigo Guarischi-Sousa, Joanna Lankester, Philip S. Tsao, Steven Buyske, Mariaelisa Graff, Laura M. Raffield, Quan Sun, Lynne R. Wilkens, Christopher S. Carlson, Charles B. Easton, Simin Liu, JoAnn E. Manson, Loïc L. Marchand, Christopher A. Haiman, Karen L. Mohlke, Penny Gordon-Larsen, Anders Albrechtsen, Michael Boehnke, Stephen S. Rich, Ani Manichaikul, Jerome I. Rotter, Noha A. Yousri, Ryan M. Irvin, The biobank at the Colorado Center for Personalized Medicine (CCPM), VA Million Veteran Program (MVP), Chris Gignoux, Kari E. North, Ruth J. F. Loos, Themistocles L. Assimes, Ulrike Peters, Charles Kooperberg, Sridharan Raghavan, Heather M. Highland, Burcu F. Darst   +72 more
doaj   +5 more sources

Psychosis endophenotypes: a gene-set-specific polygenic risk score analysis [PDF]

, 2023
Background and Hypothesis: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown.
Pain, O., Di Forti, M., Lin, K., Simons, C. J. P., Weisbrod, M., Van Haren, N., Rujescu, D., Bhat, A., Stella Calafato, M., Mata, I., Picchioni, M., Austin-Zimmerman, I., Hall, J., Iyegbe, C., Harju-Seppänen, J., Murray, R. M., Van Winkel, R., Gkofa, V., Toulopoulou, Timothea, Luykx, J. J., Irizar, H., Thygesen, J. H., Rutten, B. P. F., McQuillin, A., Arranz, M. J., Bass, N., Giegling, I., Bender, S., Van Amelsvoort, T., Kahn, R. S., McDonald, C., McIntosh, A. M., Cahn, W., Hall, M., Shaikh, M., Crespo-Facorro, B., Prata, D. P., Lawrie, S. M., Wang, B., Zartaloudi, E., Alizadeh, B. Z., Kuchenbaecker, K., Bramon, E., Powell, J., De Haan, L., Kravariti, E.   +45 more
core   +11 more sources

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention. [PDF]

Clin Pharmacol Ther
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Fransquet PD, Yu C, Tran C, Hussain SM, Bousman CA, Nelson MR, Tonkin AM, McNeil JJ, Lacaze P.   +8 more
europepmc   +2 more sources

Schizophrenia polygenic risk score influence on white matter microstructure [PDF]

, 2020
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations ...
Sukhi Shergill, Elvira Bramon, Colm McDonald, Beatriz Simões, Timothea Toulopoulou, Robin Murray, Hugo Ferreira, Evangelos Vassos, Diana Prata, Fergus Kane, Sridevi Kalidindi   +10 more
core   +1 more source

Genetic markers used in the polygenic risk score calculation.

, 2023
Genetic markers used in the polygenic risk score calculation.
Christofer Toumazou (571395), Francesca Romana Cavallo (10218765)   +1 more
core   +1 more source

Distribution of the APOE ε4 allele among polygenic score deciles.

, 2022
The distribution of APOE ε4 is presented for each polygenic score decile, ranging from 0.59 APOE ε4 allele frequency in the top decile to 0 in the bottom decile.
Robert Gerszten (12133141), Jerome I. Rotter (7634114), Amit V. Khera (7788761), John Danesh (8874), Sohail Zahid (2164087), Michael Inouye (103694), Russ Tracy (13569706), Stephen S. Rich (7634141), Susan Heckbert (4371472), Manish D. Paranjpe (9091688), Scott Ritchie (3263322), Xiuqing Guo (73591), Adam S. Butterworth (7658036), Eric S. Lander (7797983), Sekar Kathiresan (60585), Mark Chaffin (7788764)   +15 more
core   +1 more source

Polygenic score (PGS) for Refractive Error (eBioMedicine)

, 2023
A polygenic score (PGS) for refractive error. Fields are whitespace separated. Field names are: SNP CHR POS REF_allele EFFECT_allele BETA.
Jeremy Guggenheim (14766661)
core   +1 more source

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +1 more source